Unequal Contribution of Sexes in the Origin of Dog Breeds

Sundqvist, Anna-Karin; Björnerfeldt, Susanne; Leonard, Jennifer A.; Hailer, Frank; Hedhammar, Åke; Ellegren, Hans; Vilà, Carles

doi:10.1534/genetics.105.042358

Cited by 61 publications

(60 citation statements)

References 35 publications

(61 reference statements)

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“…But the results can be discordant, depending on the markers used. Note that the phylogenies of autosomal FABP4 and maternally inherited cytochrome b are rather different (Figures 3 and 4), emphasizing distinct male-and female-driven variabilities as observed in other species, e.g., the dog (Sundqvist et al 2006). It is also important to note that the FABP4 microsatellite is uncorrelated to the clade structure seen in Figure 3.…”

Section: Discussionmentioning

confidence: 86%

Unexpected High Polymorphism at the FABP4 Gene Unveils a Complex History for Pig Populations

et al. 2006

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Fatty acid bing protein 4 (FABP4) plays a key role in fat regulation in mammals and is a strong positional candidate gene for the FAT1 quantitative trait locus located on porcine chromosome 4. DNA resequencing of the FABP4 gene region in 23 pigs from 10 breeds and wild boar revealed 134 variants in 6.4 kb, representing a silent nucleotide diversity of p S ¼ 0.01, much higher than reported so far in animal domestic species. Moreover, this diversity was highly structured. Also strikingly, the FABP4 phylogenetic tree did not show any geographical or breed origin clustering, with distant breeds sharing similar haplotypes and some of the most heterozygous samples pertaining to highly inbred animals like Iberian Guadyerbas (inbreeding coefficient $0.3) or British Tamworth. In contrast, the cytochrome b (mtDNA) phylogenetic tree was coherent with geographical origin. The estimated age of the most recent common ancestor for the most divergent Iberian or Tamworth haplotypes was much older than domestication. An additional panel of 100 pigs from 8 different breeds and wild boar from Spain, Tunisia, Sardinia, and Japan was genotyped for seven selected single nucleotide polymorphisms and shows that high variability at the porcine FABP4 is the rule rather than the exception. Pig populations, even highly inbred, can maintain high levels of variability for surprisingly long periods of time.

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Section: Discussionmentioning

confidence: 86%

Unexpected High Polymorphism at the FABP4 Gene Unveils a Complex History for Pig Populations

et al. 2006

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“…These were compared with each other and with similarly characterized reference gray wolves (n = 226) from previously published studies (Sundqvist et al 2001(Sundqvist et al , 2006Musiani et al 2007). Two different Yhaplotypes were identified among C. rufus: the coyotelike type H15 that was also observed in 6% of the Texas coyote sample, and HI that the authors recognized as wolf-like and most similar to haplotypes H28 and H29 found in captive Mexican wolves (Hailer and Leonard 2008, figure 3).…”

Section: Appendix: Summaries Of Taxonomically Relevant Information Inmentioning

confidence: 90%

“…Neither wolves nor coyotes were included in this study. Sundqvist et al (2006) characterized Y-chromosome haplotype variation in a study of the origin of domestic dog breeds. Four Y-linked microsatellite loci (Olivier et al 1999) were analyzed in wild gray wolves from Alaska (n = 12) and Northwest Territories (n = 13).…”

Section: Appendix: Summaries Of Taxonomically Relevant Information Inmentioning

confidence: 99%

An Account of the Taxonomy of North American Wolves From Morphological and Genetic Analyses

Chambers

Fain

Fazio

et al. 2012

North American Fauna

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The available scientific literature was reviewed to assess the taxonomic standing of North American wolves, including subspecies of the gray wolf, Canis lupus. The recent scientific proposal that the eastern wolf, C. l. lycaon, is not a subspecies of gray wolf, but a full species, Canis lycaon, is well-supported by both morphological and genetic data. This species' range extends westward to Minnesota, and it hybridizes with gray wolves where the two species are in contact in eastern Canada and the Upper Peninsula of Michigan, Wisconsin, and Minnesota. Genetic data support a close relationship between eastern wolf and red wolf Canis rufus, but do not support the proposal that they are the same species; it is more likely that they evolved independently from different lineages of a common ancestor with coyotes. The genetic distinctiveness of the Mexican wolf Canis lupus baileyi supports its recognition as a subspecies. The available genetic and morphometric data do not provide clear support for the recognition of the Arctic wolf Canis lupus arctos, but the available genetic data are almost entirely limited to one group of genetic markers (microsatellite DNA) and are not definitive on this question. Recognition of the northern timber wolf Canis lupus occidentalis and the plains wolf Canis lupus nubilus as subspecies is supported by morphological data and extensive studies of microsatellite DNA variation where both subspecies are in contact in Canada. The wolves of coastal areas in southeastern Alaska and British Columbia should be assigned to C. lupus nubilus. There is scientific support for the taxa recognized here, but delineation of exact geographic boundaries presents challenges. Rather than sharp boundaries between taxa, boundaries should generally be thought of as intergrade zones of variable width.

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“…Low Y chromosomal genetic diversity was also observed in sheep 4 , cattle 3,5 and dogs 6,7 . These results suggest a general pattern of low male effective population size in domestic mammals, which may be attributable to breeding practices associated with domestication, where few males are selected to mate with a wider variety of females.…”

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confidence: 88%

Discovery of lost diversity of paternal horse lineages using ancient DNA

et al. 2011

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modern domestic horses display abundant genetic diversity within female-inherited mitochondrial DnA, but practically no sequence diversity on the male-inherited Y chromosome. several hypotheses have been proposed to explain this discrepancy, but can only be tested through knowledge of the diversity in both the ancestral (pre-domestication) maternal and paternal lineages. As wild horses are practically extinct, ancient DnA studies offer the only means to assess this ancestral diversity. Here we show considerable ancestral diversity in ancient male horses by sequencing 4 kb of Y chromosomal DnA from eight ancient wild horses and one 2,800-year-old domesticated horse. Both ancient and modern domestic horses form a separate branch from the ancient wild horses, with the Przewalski horse at its base. our methodology establishes the feasibility of re-sequencing long ancient nuclear DnA fragments and demonstrates the power of ancient Y chromosome DnA sequence data to provide insights into the evolutionary history of populations.

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Unequal Contribution of Sexes in the Origin of Dog Breeds

Cited by 61 publications

References 35 publications

Unexpected High Polymorphism at the FABP4 Gene Unveils a Complex History for Pig Populations

Unexpected High Polymorphism at the FABP4 Gene Unveils a Complex History for Pig Populations

An Account of the Taxonomy of North American Wolves From Morphological and Genetic Analyses

Discovery of lost diversity of paternal horse lineages using ancient DNA

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