Unknown primary tumors metastatic to liver.

Ayoub, Jean-Pierre; Hess, Kenneth R.; Abbruzzese, Marie C.; Lenzi, Renato; Raber, Martin N.; Abbruzzese, James L.

doi:10.1200/jco.1998.16.6.2105

Cited by 81 publications

(39 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…More commonly, however, hepatic SCCs are metastases that arise from upper aerodigestive primaries. The reported survival for metastatic SCC of unknown etiology involving the liver in nonimmunocompromized patients is extremely poor (32).…”

Section: Discussionmentioning

confidence: 99%

Unresectable Squamous Cell Carcinoma of Donor Origin Treated With Immunosuppression Withdrawal and Liver Retransplantation

Florman¹,

Bowne²,

Kim‐Schluger³

et al. 2004

American Journal of Transplantation

View full text Add to dashboard Cite

Posttransplantation allograft malignancy of donor origin is a rare complication after liver transplantation. In the case described, subjective fevers and nonspecific abdominal complaints nearly 6 months following cadaveric liver transplantation in a young woman prompted an evaluation which was remarkable for a large central liver mass. A poorly differentiated squamous cell carcinoma was diagnosed, but was unresectable at exploration. The tumor was confined to the liver. Histocompatibility testing using polymerase chain reaction (PCR) amplification techniques identified both donor and recipient HLA alleles. The patient was treated with chemoembolization, systemic chemotherapy and cessation of immunosuppression. Repeat biopsy 2 months later showed the tumor to be completely necrotic. With decompensated liver disease, she was relisted and retransplanted. More than 2 years later she remains disease-free with complete pathological remission. This is the only reported case of squamous cell carcinoma of donor origin arising in a transplantd liver.

show abstract

Section: Discussionmentioning

confidence: 99%

Unresectable Squamous Cell Carcinoma of Donor Origin Treated With Immunosuppression Withdrawal and Liver Retransplantation

Florman¹,

Bowne²,

Kim‐Schluger³

et al. 2004

American Journal of Transplantation

View full text Add to dashboard Cite

show abstract

“…[4] Hepatik metastazlı olan PBMT'lerin prognozu kötü seyretmekle beraber, uygun klinik ve patolojik verilerle tanı konan bazı alt tipler daha iyi prognoz göster-mektedir. [5] Primeri bilinmeyen karaci¤er metastazlı olguların %60'ında adenokarsinom saptanır-ken ikinci sıklıkta (%10-15) tedaviye daha iyi yanıt veren ve daha uzun yaam süresine sahip olabilen nöroendokrin hücre kökenli tümörler görülür. [3] Bu nedenle hastalarda histopatolojik alt tipi belirlemek önemlidir.…”

Section: Tartimaunclassified

Liver metastases with unknown primary focus in the first application: evaluation of 52 cases

Elyiğit¹,

Degirmenci²,

Akar³

et al. 2016

FNG & Bilim Tıp Dergisi

View full text Add to dashboard Cite

Objectives: This study aims to evaluate the patients with liver metastases of unknown origin followed up at the internal medicine clinic of our hospital. Patients and methods:The files of 52 patients (35 males, 17 females, mean age 62.8 years; range 29 to 87 years), followed up at the internal medicine clinic of our hospital between January 2009 and December 2015, diagnosed with metastatic liver tumors by biopsy were reviewed retrospectively. Patients were evaluated regarding their age, sex, the cause of admission, laboratory tests, histopathologic diagnosis and primary focus. Results: We found the following in the histopathological examination of the metastatic tumors; adenocarcinoma in 35 (66%), neuroendocrine tumors in nine (17%) and other tumor metastases in nine (17%) patients. The primary focus was found in 31 patients (59.6%) and colorectal was determined to be the primary focus in eight (15.3%), lung in eight (15.3%), pancreas in seven (13.4%), cholangiocellular in four (7.6%) and other organs in three (5.7%) patients. Conclusion: In our study, the incidence of neuroendocrine tumors and the incidence of patients whose primary focus was determined were high in patients admitted with metastatic liver tumor of unknown primary focus. We suggest that biopsy should be performed in patients of metastatic liver tumors. Primeri bilinmeyen metastatik tümörler (PBMT) bavuruda primer tümör bölgesinin yapı-lan tüm detaylı öykü, muayene ve temel laboratuvar testlerine ra¤men saptanamadı¤ı metastatik hastalık grubu olarak tanımlanmaktadır.[1] Tüm malignitelerin yaklaık %5-10'unu olutururlar.[2]Primeri bilinmeyen metastatik tümörlerin yaklaık %33'ünü karaci¤er metastazları olutur ve prognozu kötüdür. [3] Primeri bilinmeyen metastatik karaci¤er tümörlü hastaların %60-80'ini

show abstract

“…Metastases of an unknown primary site are found in about 5% of all cancer patients [1][2][3] . The recent advances in molecular technology, including gene expression profiling, raise the expectation for improved diagnosis of cancer of unknown primary (CUP).…”

Section: Introductionmentioning

confidence: 99%

“…This is needed to identify subsets of patients who could potentially respond to therapy. The liver is involved in about a third of patients with CUP [3] . In about 50% of these patients, the primary tumor is carcinoma of the lung, colon, rectum, or pancreas.…”

Section: Introductionmentioning

confidence: 99%

Hairy cell leukemia presenting as multiple discrete hepatic lesions

Sahar¹,

Schiby²,

Davidson³

et al. 2009

WJG

View full text Add to dashboard Cite

The involvement of hairy cell leukemia in the liver is in the form of portal and sinusoidal cellular infiltration. Here we describe the first case of hepatic hairy cell leukemia presenting as multiple discrete lesions, which was treated successfully. We suggest that in the investigation of discrete hepatic lesions in cases of cancer of unknown primary, hairy cell leukemia should be considered. The excellent response of hairy cell leukemia to therapy highlights the need for such a consideration.

show abstract

Unknown primary tumors metastatic to liver.

Cited by 81 publications

References 16 publications

Unresectable Squamous Cell Carcinoma of Donor Origin Treated With Immunosuppression Withdrawal and Liver Retransplantation

Unresectable Squamous Cell Carcinoma of Donor Origin Treated With Immunosuppression Withdrawal and Liver Retransplantation

Liver metastases with unknown primary focus in the first application: evaluation of 52 cases

Hairy cell leukemia presenting as multiple discrete hepatic lesions

Contact Info

Product

Resources

About