Hairy cell leukemia presenting as multiple discrete hepatic lesions

Abstract

The involvement of hairy cell leukemia in the liver is in the form of portal and sinusoidal cellular infiltration. Here we describe the first case of hepatic hairy cell leukemia presenting as multiple discrete lesions, which was treated successfully. We suggest that in the investigation of discrete hepatic lesions in cases of cancer of unknown primary, hairy cell leukemia should be considered. The excellent response of hairy cell leukemia to therapy highlights the need for such a consideration.

Oncological management dilemma: a rare presentation of hairy cell leukaemia with hepatic involvement presenting concomitantly with pancreatic adenocarcinoma

“…Sahar et al also wrote a case report about a patient who presented with a liver mass and was found to have metastatic HCL. 5 The patient in this case was treated with cladribine and had a good response.…”

Hairy Cell Leukemia: Hepatic Affinity Status Post Splenectomy

“…In the liver, neoplastic hairy cells exhibit angiomatous-like characteristics by infiltrating and proliferating in hepatic sinusoids. Traditionally, splenomegaly occurs from hyperplasia of the splenic red pulp and HCL infiltration [ 7 , 12 ]. However, there are almost no cases in the current literature highlighting a reason for hepatic affinity and infiltration as was observed in this particular case.…”