Universal leukoreduction decreases the incidence of febrile nonhemolytic transfusion reactions to RBCs

King, Karen E.; Shirey, R. Sue; Thoman, Sandra K.; Bensen-Kennedy, Debra; Tanz, Warren S.; Ness, Paul M.

doi:10.1046/j.0041-1132.2004.00609.x

Cited by 182 publications

(144 citation statements)

References 13 publications

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…12 Leukoreduction of these stored units have been consistently associated with low rates of non-hemolytic febrile transfusion reactions. [13][14][15] Hebert and colleagues evaluated the impact of leukoreduction across 23 Canadian hospitals subsequent to a universal prestorage leukoreduction program. 16 Outcomes evaluated included mortality, infections, fever and antibiotic use among 14,786 patients (6,982 during a period prior to the implementation, and 7,804 after the program's implementation) who received RBC transfusions secondary to cardiac surgery, repair from hip fracture, or during their intensive care unit stay following a surgical intervention or trauma.…”

Section: Discussionmentioning

confidence: 99%

Red Blood Cell Transfusions Impact Pneumonia Rates After Coronary Artery Bypass Grafting

Likosky

Paone

Zhang

et al. 2015

The Annals of Thoracic Surgery

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Red Blood Cell Transfusions Impact Pneumonia Rates After Coronary Artery Bypass Grafting

Likosky

Paone

Zhang

et al. 2015

The Annals of Thoracic Surgery

View full text Add to dashboard Cite

show abstract

“…The overall incidence of febrile non-hemolytic transfusion reactions has decreased significantly since leukoreduction has been implemented [67].…”

Section: Pro-inflammatory State After Blood Transfusionmentioning

confidence: 99%

Transfusion-transmissible infections and transfusion-related immunomodulation

Buddeberg

Schimmer

Spahn

2008

Best Practice & Research Clinical Anaesthesiology

View full text Add to dashboard Cite

Transfusion-transmissible infections and transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years. However, after human immunodeficiency virus and hepatitis B and C virus transmission were successfully reduced, new pathogens are threatening the safety of the blood supply, especially in the face of rising numbers of immunocompromised transfusion recipients. Despite new standards in the manufacture and storage of blood products, bacterial contamination still remains a considerable cause of transfusion-related morbidity and mortality. Better allograft survival in kidney transplant patients and higher cancer recurrence rate in surgical oncology patients after allogeneic blood transfusions highlighted a previously underestimated side-effect: transfusion-related immunomodulation (TRIM). The precise pathomechanism still remains uncertain; however, its mostly deleterious effects--such as a higher incidence of postoperative or nosocomial infections--is increasingly accepted. Although transfusion-related immunomodulation is thought to be mediated mainly by donor white blood cells, the benefit of leukoreduction on overall mortality and on infectious complications is highly debatable. Transfusion-transmissible infections and Transfusion-related immunomodulation Transfusion-transmissible infections and Transfusion-related immunomodulation AbstractThe risk of acquiring a transfusion-transmitted infection has declined in recent years.

show abstract

“…8 In another study carried by Karen E et al who compared the results of incidence of FNHTRs over two time periods after introduction of universal leucoreduced PRBCs found that there was a significant difference in the incidence of FNHTRs seen between the two-time periods (0.37% in 1994 vs. 0.19% in 2001, p = 0.0008). 9 Kumar H et al also showed that after the introduction of leucodepletion of blood for thalassemics at their center, the incidence of non-haemolytic febrile transfusion reactions (NHFTR) fell from 4% in 2002 to 1% in 2003. 7 On comparing our study with the above mentioned studies we get the similar results which indicate that prestorage leukoreduction of RBCs is beneficial in reducing the incidence of FNHTRs.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of buffy coat leucoreduced packed red blood cells in decreasing febrile non-hemolytic transfusion reactions in thalassemic patients

et al. 2017

View full text Add to dashboard Cite

Background: Blood transfusions have always been associated with a number of adverse outcomes which have steadily decreased over years owing to new discoveries and technical advancements. Thalassemic patients are more prone to transfusions related complications owing to repeated transfusions. Study of these reactions and correlating them with the leucodepletion status of the transfused packed red blood cells (PRBCs) reduces transfusion complications due to the transfused leukocytes.Methods: This is a prospective study carried out on 1750 transfusions in 138 thalassemic patients at our institute between August 2015 and March 2016. The total transfusions were classified into four categories depending on the leucodepletion status of the PRBC’s. The clinical records and the reaction workup done to rule out the hemolytic reactions were recorded.Results: Reactions were recorded in 17 (0.97%) out of a total of 1750 transfusions. 14 (4.1%) reactions were recorded on transfusions of non-leukoreduced PRBCs whereas only 2 (0.16%) reactions were recorded in leucoreduced (buffy coat) PRBCs. 1 (0.8%) reaction was recorded on transfusion of leucodepleted PRBCs done by bedside filter. No reaction was documented when buffy coat leucoreduced PRBCs were used along bedside filter.Conclusions: Elimination of WBCs from donor packed cells results in reduction of adverse reactions following blood transfusion. Various methods of leucoreduction have been successfully employed in the past and shown to reduce transfusion reactions in multi transfused thalassemic patients. In resource limited settings, leukoreduction using the buffy-coat method is an effective intervention in reducing the transfusion reactions.

show abstract

Universal leukoreduction decreases the incidence of febrile nonhemolytic transfusion reactions to RBCs

Cited by 182 publications

References 13 publications

Red Blood Cell Transfusions Impact Pneumonia Rates After Coronary Artery Bypass Grafting

Red Blood Cell Transfusions Impact Pneumonia Rates After Coronary Artery Bypass Grafting

Transfusion-transmissible infections and transfusion-related immunomodulation

Effectiveness of buffy coat leucoreduced packed red blood cells in decreasing febrile non-hemolytic transfusion reactions in thalassemic patients

Contact Info

Product

Resources

About