Universal hydrophilic coating of thermoplastic polymers currently used in microfluidics

Zilio, Caterina; Solá, Laura; Damin, Francesco; Faggioni, Lucia; Chiari, Marcella

doi:10.1007/s10544-013-9810-8

Cited by 49 publications

(38 citation statements)

References 40 publications

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“…Also, UV/ozone method requires 2 spectral lines, the first to produce ozone and the other to generate oxygen from ozone, while UV grafting requires the adsorption of photoinitiator . Other chemical surface treatments include chemical vapor deposition, layer‐by‐layer deposition, sol‐gel coatings, and silanization . These have all demonstrated to render PDMS good hydrophilic behavior as well as low hydrophobic recovery.…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic surface modification of polydimetylsiloxane‐co‐2‐hydroxyethylmethacrylate (PDMS‐HEMA) by Silwet L‐77 (heptamethyltrisiloxane) surface treatment

Kalulu

Zhang

Xia

et al. 2018

Polymers for Advanced Techs

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Biomaterials and their host organism's quintessential place of interaction are the surfaces of materials, as transportation of liquids within microchannels requires hydrophilic surfaces. Modifying the hydrophobic surface of polydimethylsiloxane (PDMS) into a hydrophilic one which can be used in biomaterials remains a big challenge. Herein, PDMS-hydroxyethylmethacrylate (HEMA) films were prepared by the condensation of PDMS using isophorone diisocyanate as a cross-linker, followed by the incorporation of HEMA via radical copolymerization. The asprepared PDMS-HEMA films were thereafter hydrophilized via physical treatment with heptamethyltrisiloxane. The surface properties of the obtained PDMS-HEMA films were characterized in wettability, morphology, topography, swelling, mechanical properties, and protein adsorption. Compared to pristine PDMS-HEMA as control, the surface wettability, roughness, and protein adsorption of the hydrophilized PDMS-HEMA films were significantly improved while the films also exhibited excellent optical properties. However, the improvement of the swelling properties remains insignificant, indicating that the interior morphology was still based on the hydrophobic siloxane PDMS. The long-term hydrophilicity was considered good as no significant hydrophobic recovery was noticeable in a period of 5 months after treatment.

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Section: Introductionmentioning

confidence: 99%

Hydrophilic surface modification of polydimetylsiloxane‐co‐2‐hydroxyethylmethacrylate (PDMS‐HEMA) by Silwet L‐77 (heptamethyltrisiloxane) surface treatment

Kalulu

Zhang

Xia

et al. 2018

Polymers for Advanced Techs

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“…The presence of pendant silane groups is critical for ensuring the formation of a stable polymer film on various substrates. 25 The robustness of the coating is also a result of the other two components, DMA that interacts with substrates through hydrogen bonding, and GMA that enhances the solidity of the film by reacting with surface silanols.…”

Section: Introductionmentioning

confidence: 99%

Controlling electroosmotic flows by polymer coatings: A joint experimental-theoretical investigation

Monteferrante

Solá

Cretich

et al. 2015

The Journal of Chemical Physics

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We analyze the electroosmotic flow (EOF) of an electrolytic solution in a polymer coated capillary electrophoresis tube. The polymeric density, charge, thickness, and the capillary tube charge vary as a function of pH and produce a non-trivial modulation of the EOF, including a flow reversal at acid pH conditions. By means of a theoretical argument and numerical simulations, we recover the experimental curve for the EOF, providing a firm approach for predictive analysis of electroosmosis under different polymeric coating conditions. A proposed application of the approach is to determine the near-wall charge of the coating to be used for further quantitative analysis of the electroosmotic flow and mobility.

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“…Second, the NanoChip may not be reusable due to the potential adsorption of different chemicals and reagents on channel walls. To address this challenge, channels can be treated with appropriate antifouling coatings to guarantee the reusability of the chip . Additionally, it is realized that the fabrication process of the present NanoChip platform is still relatively complex.…”

Section: Perspectives and Conclusionmentioning

confidence: 99%

Reproducible and Scalable Generation of Multilayer Nanocomposite Constructs for Ultrasensitive Nanobiosensing

Salahandish

Zargartalebi

Khetani

et al. 2019

Adv Materials Technologies

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Electrochemical nanobiosensors are ultrasensitive tools used for detection and monitoring of various markers in biofluids. In the absence of reliable techniques for large‐scale production of reproducible nanomaterial structures on the electrodes, they are created individually in batch‐production. This has become a substantial hurdle in the practical implementation of electrochemical nanobiosensors. An automated microfluidic‐based platform (NanoChip) is presented for reproducible and scalable formation of complex nanomaterial constructs with a defined order of nanocomposites and biomaterials to create ultrasensitive nanobiosensors. The automated liquid handling system of the setup delivers reagents to electrodes inserted temporarily into the chip for modifying their surfaces by depositing different nanomaterials. The NanoChip platform is used for the creation of a multilayer nanocomposite structure on the electrode surface. These reproducible nanobiosensors are used for detecting breast cancer cells in the blood. The nanobiosensors offered a dynamic detection range of 10 to 5 × 106 cells mL−1. Performance of sensors produced from NanoChip shows similar selectivity and operational range along with improved sensitivity and reproducibility compared to sensors developed using batch process. These features make automated Nanochip technology a versatile tool for producing nanosensors for the ultrasensitive detection of various markers in biomedical, clinical, energy, and environmental applications.

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Universal hydrophilic coating of thermoplastic polymers currently used in microfluidics

Cited by 49 publications

References 40 publications

Hydrophilic surface modification of polydimetylsiloxane‐co‐2‐hydroxyethylmethacrylate (PDMS‐HEMA) by Silwet L‐77 (heptamethyltrisiloxane) surface treatment

Hydrophilic surface modification of polydimetylsiloxane‐co‐2‐hydroxyethylmethacrylate (PDMS‐HEMA) by Silwet L‐77 (heptamethyltrisiloxane) surface treatment

Controlling electroosmotic flows by polymer coatings: A joint experimental-theoretical investigation

Reproducible and Scalable Generation of Multilayer Nanocomposite Constructs for Ultrasensitive Nanobiosensing

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