After receptor selections are made, there must next be a match with an appropriate sensing platform and transduction method. Biology has done an exceptional job in integrating sensing and actuation in organisms to maintain situational awareness, initiate actions and control multiple processes, all highly desirable capabilities for a soldier in the field. Though manmade systems are currently less flexible and often lack a truly integrated stimulus-response chain of events, progress is being made. As described in this chapter, many transduction approaches are now available and sensors that mimic all five senses are currently in development.