United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment

“…Several studies have reported improvements in visual acuity following CXL (Ivarsen & Hjortdal, 2013; Hersh et al, 2017). Direct illumination of UVA-light towards the eye has raised concerns with regards to the safety of CXL.…”

Section: Keratoconusmentioning

confidence: 99%

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Sharif

Bak‐Nielsen

Hjortdal

et al. 2018

Progress in Retinal and Eye Research

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Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered. Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea. Hormone levels have been reported to alter corneal thickness, curvature, and sensitivity during different times of menstrual cycle. Surprisingly, the role of sex hormones in corneal diseases and KC has been largely neglected. Prolactin-induced protein, known to be regulated by sex hormones, is a new KC biomarker that has been recently proposed. Studies herein discuss the role of sex hormones as a control mechanism for KC onset and progression and evidence supporting the view that prolactin-induced protein is an important hormonally regulated biomarker in KC is discussed.

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“…98 Also, since the role of inflammation in the development of symptoms is welldefined, many studies have suggested anti-inflammatory agents administration. For instance, corneal collagen crosslinking is reported to be effective in improving the maximum keratometry value and slowing down the progression of the disease, with an excellent safety profile.…”

Section: Discussionmentioning

confidence: 99%

An analytical enrichment‐based review of structural genetic studies on keratoconus

Panahi

Azimi

Naderi

et al. 2018

J of Cellular Biochemistry

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Keratoconus is a progressive bilateral corneal protrusion that leads to irregular astigmatism and impairment of vision. Keratoconus is an etiologically heterogeneous corneal dystrophy and both environmental and genetic factors play a role in its etiopathogenesis. In this analytical review, we have studied all the genes that are structurally associated with keratoconus and have tried to explain the function of each gene and its association with other eye disorders in a concise way. In addition, using gene set enrichment analysis, it was attempted to find the most important impaired metabolic pathways in keratoconus. Several genetic studies have been carried out on keratoconus and several genes have been identified as risk factors involved in the etiology of the disease. In the current study, 16 studies, including nine association studies, five genome‐wide association studies, one linkage study, and one meta‐analysis, were reviewed and based on the 19 genes found, enrichment was performed and the most important metabolic pathways involved in the disease were identified. The enrichment results indicated that the two pathways, interleukin 1 processing and assembly of collagen fibrils, are significantly associated with the disease. Obviously, the results of this study, in addition to providing information about the genes involved in the disease, can provide an integrated insight into the gene‐based etiology of keratoconus and therapeutic opportunities thereof.

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United States Multicenter Clinical Trial of Corneal Collagen Crosslinking for Keratoconus Treatment

Cited by 188 publications

References 43 publications

Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Comparison of standard and accelerated corneal cross‐linking for the treatment of keratoconus: a meta‐analysis

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

An analytical enrichment‐based review of structural genetic studies on keratoconus

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