Unit Processes in Organic Synthesis (Groggins, P. H.)

Calcott, W. S.

doi:10.1021/ed012p348.3

Cited by 5 publications

(5 citation statements)

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“…The fast component reminds us of the fast band observed in porous Si. Gated P L measurements at 2 K indicate [4] that also in our samples this band is centered in the blue-green region, and that it has a characteristic lifetime in the ns range. As for porous Si [5], this band is probably associated to SiO,.…”

Section: Pl As a Function Of Temperature And Timesupporting

confidence: 59%

Efficient Visible‐Light Emission from Si/CaF² (111) Heterostructures Grown by Molecular Beam Epitaxy

Vervoort¹,

Bassani²,

Mihalcescu

et al. 1995

Physica Status Solidi (b)

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Section: Pl As a Function Of Temperature And Timesupporting

confidence: 59%

Efficient Visible‐Light Emission from Si/CaF² (111) Heterostructures Grown by Molecular Beam Epitaxy

Vervoort¹,

Bassani²,

Mihalcescu

et al. 1995

Physica Status Solidi (b)

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“…As a starting point for establishing DoE, a risk assessment was conducted by means of previously determined production scale parameters. In this case study, two study designs generated by DoE were integrated and subjected to process characterization . In this case study, three parameters—buffer pH, flow rate, and loading amount—were evaluated (Table (a)).…”

Section: Methodsmentioning

confidence: 99%

“…In this case study, two study designs generated by DoE were integrated and subjected to process characterization. [10][11][12][13] In this case study, three parametersbuffer pH, flow rate, and loading amount-were evaluated (Table 1(a)). A custom design model was created in the JMP software and was used for analysis.…”

Section: Calculation Of N-glycan Contentmentioning

confidence: 99%

Application of the Quality‐by‐Design (QbD) Approach for Erythropoietin Alpha Purification

Kim

Seo

Kwon

et al. 2019

Bulletin Korean Chem Soc

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This study was aimed at process characterization and improving quality of purification of erythropoietin α, a biopharmaceutical agent. In biopharmaceutical manufacturing, quality should always be targeted to ensure safety and efficacy. Design‐of‐experiments–based approaches have been explored to rapidly and efficiently achieve an optimized yield and an increased understanding of a product and process variables affecting the product's critical quality attributes in the biopharmaceutical industry; this system is known as the quality‐by‐design approach. Changes in three critical process parameters—buffer pH, flow rate, and loading amount—were evaluated. Process characterization was conducted on a scaled‐down model previously validated by comparison with data from a large‐scale production facility. Seven critical quality attributes—relative aggregate content, host cell protein, host cell deoxynucleotides, endotoxin, Z‐value (N‐glycan score), relative content of charge isomers, and step yield—were analyzed. Multivariate regression analysis was performed to establish statistical prediction models for performance indicators and quality attributes; accordingly, we constructed contour plots and conducted a Monte Carlo simulation to clarify the design space. As a result of the optimization analysis of the purification process, it was confirmed that proven acceptance ranges were optimized as follows: loading amount (mg/mL) 0.4–4.0, buffer pH 7.0–8.0, and flow rate (mL/min) 0.5–1.6.

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“…E. coli A39 (araA) was a generous gift of Dr. Hogg, Department of Microbiology, Case Western Reserve University, Cleveland, OH, and was grown to late log-early stationary phase in a lactoseminimal salts medium [11] supplemented with 1 mg/ml casein hydrolysate. Organisms were harvested and washed by centrifugation from and resuspension in 0.85% saline.…”

Section: Organism and Cultural Conditionsmentioning

confidence: 99%

Rifampicin inhibits protein synthesis in toluene-treated Escherichia coli

Ghani

1981

FEMS Microbiology Letters

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Unit Processes in Organic Synthesis (Groggins, P. H.)

Cited by 5 publications

References 0 publications

Efficient Visible‐Light Emission from Si/CaF² (111) Heterostructures Grown by Molecular Beam Epitaxy

Efficient Visible‐Light Emission from Si/CaF² (111) Heterostructures Grown by Molecular Beam Epitaxy

Application of the Quality‐by‐Design (QbD) Approach for Erythropoietin Alpha Purification

Rifampicin inhibits protein synthesis in toluene-treated Escherichia coli

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Unit Processes in Organic Synthesis (Groggins, P. H.)

Cited by 5 publications

References 0 publications

Efficient Visible‐Light Emission from Si/CaF2 (111) Heterostructures Grown by Molecular Beam Epitaxy

Efficient Visible‐Light Emission from Si/CaF2 (111) Heterostructures Grown by Molecular Beam Epitaxy

Application of the Quality‐by‐Design (QbD) Approach for Erythropoietin Alpha Purification

Rifampicin inhibits protein synthesis in toluene-treated Escherichia coli

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Product

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Efficient Visible‐Light Emission from Si/CaF² (111) Heterostructures Grown by Molecular Beam Epitaxy

Efficient Visible‐Light Emission from Si/CaF² (111) Heterostructures Grown by Molecular Beam Epitaxy