Unique genetic alterations and clinicopathological features of hepatocellular adenoma in Chinese population

Liu, Haiping; Zhao, Qian; Jin, Guang‐Zhi; Qian, You–Wen; Gu, Yijin; Dong, Hui; Lu, Xinyuan; Wu, Mengchao

doi:10.1016/j.prp.2015.09.003

Cited by 7 publications

(11 citation statements)

References 36 publications

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“…A higher incidence of hepatocellular adenoma in male patients in our series seems incongruent with previous indications of a higher incidence in the female sex . Our findings of a higher incidence in men has been also observed in other Asian countries, such as Japan and China . Sasaki et al and Liu et al have reported that respectively, 50% and 70% of patients in their hepatocellular adenoma series were male .…”

Section: Discussioncontrasting

confidence: 61%

“…[1][2][3][4][5] Our findings of a higher incidence in men has been also observed in other Asian countries, such as Japan and China. [11][12][13] Sasaki et al and Liu et al have reported that respectively, 50% and 70% of patients in their hepatocellular adenoma series were male. 12,13 Our data had overall similarity to the two studies and corroborated their observation of rare oral contraceptive use in female individuals.…”

Section: Discussionmentioning

confidence: 97%

“…[11][12][13] Sasaki et al and Liu et al have reported that respectively, 50% and 70% of patients in their hepatocellular adenoma series were male. 12,13 Our data had overall similarity to the two studies and corroborated their observation of rare oral contraceptive use in female individuals. Only three women with hepatocellular adenoma in our series documented oral contraceptive use.…”

Section: Discussionmentioning

confidence: 97%

“…Hepatocellular adenoma is exceptionally rare in East Asian countries. Thus, its clinicopathologic characteristics in East Asian populations are poorly defined . It is not known if the distribution of molecular subtypes and risk of malignant transformation of hepatocellular adenoma differs in Taiwan, where viral hepatitis is prevalent.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, its clinicopathologic characteristics in East Asian populations are poorly defined. [11][12][13] It is not known if the distribution of molecular subtypes and risk of malignant transformation of hepatocellular adenoma differs in Taiwan, where viral hepatitis is prevalent. In this study, we analyzed the molecular and clinicopathologic features of hepatocellular adenoma in a single center in Taiwan to better assess this rare hepatic neoplasm.…”

Section: Introductionmentioning

confidence: 99%

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Hepatocellular adenoma in Taiwan: Distinct ensemble of male predominance, overweight/obesity, and inflammatory subtype

Huang

Liau

Jeng

et al. 2019

J of Gastro and Hepatol

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Background and Aim The clinicopathologic features of hepatocellular adenoma in Asian populations have been poorly defined. The study aimed to characterize this rare entity in a single institution in Taiwan. Methods In total, 45 hepatocellular adenomas from 1995 to 2018 were included and sent for pathologic review and molecular subtyping. Results The numbers of patients with hepatocellular adenoma has doubled in the recent decade. Surprisingly, men outnumbered women in our cohort (n = 26, 58% vs N = 19, 42%). A collection of clinical information revealed that overweight/obesity accounts for most of the associated conditions of hepatocellular adenoma. Only three women took oral contraceptives. There were 34 inflammatory (75%), three LFABP‐negative (7%), four β‐catenin activated (9%), and four unclassified (9%) hepatocellular adenomas. Ten inflammatory hepatocellular adenomas demonstrated strong and homogeneous glutamine synthetase staining and were thus also β‐catenin activated. Notably, overweight and obesity were significantly associated with inflammatory hepatocellular adenoma than other subtypes (P = .029 and .056, respectively) and were strongly correlated with steatosis in background liver (P = .028 and.007, respectively). Malignant transformation (four borderline tumors and two hepatocellular carcinomas) was identified in six adenomas (two women and four men). All six hepatocellular adenomas with malignancy were β‐catenin activated; β‐catenin activation could serve as a biomarker for malignant progression. Conclusions The clinicopathologic features of hepatocellular adenoma in Taiwan are distinct from those reported in Western countries. Rare oral contraceptive usage and an emerging epidemic of overweight/obesity in Taiwan provides new insights into the pathogenesis of hepatocellular adenoma.

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Section: Discussioncontrasting

confidence: 61%