MR imaging of hepatocellular adenomas on genotype-phenotype classification: A report from China

Wang, Heqing; Yang, Chun; Rao, Sheng-Xiang; Ji, Yuan; Sheng, Ruofan; Zeng, Mengsu

doi:10.1016/j.ejrad.2018.01.023

Cited by 11 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In western countries, only ~10% of HCAs are observed in males. A slight male preponderance or a practically equal distribution of male and female patients have been reported in studies from eastern countries with very low OC use 22,113,114 . In these studies, IHCA was the most frequent subtype observed both in the total study population and in the male patients.…”

Section: Hca In Particular Clinicopathological Contextsmentioning

confidence: 67%

Hepatocellular adenoma: what we know, what we do not know, and why it matters

et al. 2022

View full text Add to dashboard Cite

Hepatocellular adenoma: what we know, what we do not know, and why it mattersIn the last two decades there has been significant progress in research on and diagnosis of hepatocellular adenoma (HCA), resulting in the establishment of a molecular and immunohistological HCA classification. This review aims to fine-tune the current expertise in order to enhance the histopathological diagnostic possibilities, by refining issues that are already known, addressing diagnostic difficulties, and identifying still unknown aspects of HCA. We discuss novel methods to identify HCA subtypes, in particular the sonic hedgehog HCAs and the interpretation of glutamine synthetase patterns for the recognition of b-cateninmutated HCAs. The major complications of HCAs, i.e. bleeding and malignant transformation, are considered, including the dilemmas of atypical and borderline lesions. HCAs in different clinical and geographical settings, e.g. pregnancy, cirrhosis and non-western countries, are also discussed. The natural history of the different HCA subtypes in relation to age, sex and risk factors is a feature that is still insufficiently investigated. This is also true for the risks of clinical bleeding and malignant transformation in association with HCA subtypes. As HCA is a relatively rare tumour, a multicentre and multidisciplinary approach across geographical boundaries will be the appropriate method to establish prospective programmes with which to identify, classify and manage HCAs, focusing on several aspects, e.g. aetiology, underlying liver disease, complications, regression, and growth. Updating what we know and identifying and addressing what we do not know matters for optimal patient management.

show abstract

Section: Hca In Particular Clinicopathological Contextsmentioning

confidence: 67%

Hepatocellular adenoma: what we know, what we do not know, and why it matters

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Hepatocellular adenoma is a rare benign neoplasia. It is subdivided into four types according to the Bordeaux group by classification of the genotype-phenotype: inflammatory, nuclear alpha-1 mutagenic factor, beta-catenin mutated, or with no classification [5,6] . This classification is clinically important for the decision as to the treatment, due to a higher possibility of malignant transformation in determined subtypes.…”

Section: Discussionmentioning

confidence: 99%

“…There are variable characteristics in relation to the vascularization or the dynamics after the injection of gadolinium, but in most cases it presents as hypervascular in the arterial phase. Heterogeneity in the signal intensity is one of the most constant characteristics of the adenoma and results from the high variation of pathologic changes that can show in the tumor [5,10] . In rare cases, an adenoma can present as a 17cm mass with central cavitation secondary to necrosis to the point to mimicking a cystic lesion in the imaging examinations.…”

Section: Discussionmentioning

confidence: 99%

Hepatic adenoma mimicking liver hydatid disease: Case report

Miranda¹,

Amorim²,

Miranda³

et al. 2020

Int. J. Surg. Sci.

View full text Add to dashboard Cite

Case Report: A 34-year-old female obese patient, married, who lived in Abreu e Lima (PE), with a history of moderate abdominal pain in the right flank and weight loss (10 kg in 7 months): She visited Para State two years ago and denied having used any oral hormonal contraceptive. Imaging exams showed big cystic and multiloculated formations in the liver, with the largest being of 16 x 13 x 14cm. Due to the aspects of the image, epidemiology and the symptoms of the patient, a diagnosis of hydatid cyst was considered, and the patient was treated with praziquantel and albendazole. The surgical procedure was proposed based on the recommendations of the WHO for the treatment of hydatic disease, even without the result of the serology test. Operatory findings showed cystic lesions with a pasty and amorphous content, of yellowgreen aspect. The surgical specimen evaluation showed a hepatic adenoma with necrotic tissue and central cavitation. The diagnosis was confirmed by immunohistochemistry. The serology test for echinococcosis was negative. The patient had no further complications and was discharged in good clinical condition. Conclusion:We presented rich iconographic information of all aspects of this case and reviewed all the differential diagnoses for cystic lesions of the liver.

show abstract

“…Some Authors have recently compared the behaviour regarding diffusion-weighted images of MRI among the different HCA types. They have revealed different apparent diffusion coefficient values among the HCA types, the lowest being for β-HCA, and they therefore found that the apparent diffusion coefficient value is a potential marker of malignant transformation[28]. Obviously, future studies are needed to validate or to redefine these data permitting an imaging diagnosis for almost all HCA types with a high rate of malignant degeneration.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular adenoma: An unsolved diagnostic enigma

Renzulli¹,

Clemente²,

Tovoli³

et al. 2019

WJG

View full text Add to dashboard Cite

Hepatocellular adenoma (HCA) is a rare benign liver tumour associated with the use of oral contraceptives or other steroid medications which occurs predominantly in young and middle-aged women. Unlike other benign liver tumours, an HCA may be complicated by bleeding and malignant transformation. HCAs have been divided into four subtypes based on molecular and pathological features: hepatocyte nuclear factor 1α-mutated HCA, inflammatory HCA, β-catenin-mutated HCA, and unclassified HCA. β-catenin-mutated HCA has the highest risk of haemorrhage or malignant transformation. In the latest upgrade of the guidelines regarding the management of benign liver tumours published in 2016 by the European Association for the Study of the Liver, magnetic resonance imaging (MRI) was recognized to be superior to all other imaging modalities in detecting HCAs and in being able to subtype HCAs up to 80%, with positive identification of 1α-mutated HCA or inflammatory HCA achievable with > 90% specificity. This review analyzed the imaging features of HCA using MRI with hepato-specific contrast agents, focusing on the limitations in the HCA characterization.

show abstract

MR imaging of hepatocellular adenomas on genotype-phenotype classification: A report from China

Cited by 11 publications

References 19 publications

Hepatocellular adenoma: what we know, what we do not know, and why it matters

Hepatocellular adenoma: what we know, what we do not know, and why it matters

Hepatic adenoma mimicking liver hydatid disease: Case report

Hepatocellular adenoma: An unsolved diagnostic enigma

Contact Info

Product

Resources

About