Unique expression of connexins in the human cochlea

Liu, Wei; Boström, Marja; Kinnefors, Anders; Rask‐Andersen, Helge

doi:10.1016/j.heares.2009.01.010

Cited by 74 publications

(82 citation statements)

References 33 publications

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“…We suspect that a stimulatory and protective action from these cells can play a pivotal role in the survival of SGs. Recently, we discovered that these surrounding cells form a honeycomb-like structure enclosing many perikarya and that these cells expressed connexin 43 [Liu et al, 2009]. This could suggest that satellite cells communicate and may give trophic supply to a larger population of cells.…”

Section: Discussionmentioning

confidence: 98%

Effects of Neurotrophic Factors on Growth and Glial Cell Alignment of Cultured Adult Spiral Ganglion Cells

Boström¹,

Khalifa²,

Boström³

et al. 2009

Audiol Neurotol

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Adult spiral ganglion cells were cultured in chorus to assess the influence of the neurotrophins brain-derived neurotrophic factor, neurotrophin 3 and glial cell line-derived neurotrophic factor (GDNF) on neurite growth and Schwann cell alignment. Over 1500 measurements were collected using each factor at 10 ng/ml and all three in combination. Evaluation was made with GDNF at concentrations of up to 100 ng/ml. Neurite dimensions were assessed at days 5, 7, 9 and 11 using a computer-based program (Axon Analyzer). GDNF had a strong effect on spiral ganglion cell growth almost attaining the level of all three factors in combination. GDNF increased glial cell alignment and nerve bundle formation. Results show the potential of GDNF to maintain and possibly restore auditory nerve integrity.

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Section: Discussionmentioning

confidence: 98%

Effects of Neurotrophic Factors on Growth and Glial Cell Alignment of Cultured Adult Spiral Ganglion Cells

Boström¹,

Khalifa²,

Boström³

et al. 2009

Audiol Neurotol

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“…In the stria vascularis, Cx43 immunoreactivity was also found [135]. Cx30, Cx26, and Cx36 (GJA9; 15q14) immunoreactivity was also associated with spiral ganglion type I neurons, Cx36 being a GJ protein enriched in neurons [74]. Most recently, Cx29 originally recognized as abundantly expressed in murine Schwann cells and oligodendrocytes [3,73,89] was also found in cochlear Schwann cells where it is required for the normal development and function of the auditory nerve of mice [136].…”

Section: Cx47 and Pelizaeus-merzbacher-like Diseasementioning

confidence: 99%

“…Here, Cx26 (GJB2; 13q11-q12) is the most prominent human Cx isoform expressed [64]. Cx26 colocalizes with Cx30 (GJB6; 13q12), a second Cx found in the inner ear between supporting cells including Claudius cells and Deiter cells [74]. In vertebrates, Cx26 and Cx30 proteins were found in the spiral limbus, the spiral ligament, and the stria vascularis of higher vertebrates [98,134].…”

Section: Cx47 and Pelizaeus-merzbacher-like Diseasementioning

confidence: 99%

Gap junctions in inherited human disease

Zoidl

Dermietzel

2010

Pflugers Arch - Eur J Physiol

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Gap junctions (GJ) provide direct intercellular communication. The structures underlying these cell junctions are membrane-associated channels composed of six integral membrane connexin (Cx) proteins, which can form communicating channels connecting the cytoplasms of adjacent cells. This provides coupled cells with a direct pathway for sharing ions, nutrients, or small metabolites to establish electrical coupling or balancing metabolites in various tissues. Genetic approaches have uncovered a still growing number of mutations in Cxs related to human diseases including deafness, skin disease, peripheral and central neuropathies, cataracts, or cardiovascular dysfunctions. The discovery of a growing number of inherited human disorders provides an unequivocal demonstration that gap junctional communication is crucial for diverse physiological processes.

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“…Gap junctions are made of connexins, a large family of membrane proteins allowing both ionic and metabolic coupling between adjacent cells, not only in the inner ear, but also in several tissues such as skin, neurons and colon [13,14]. Immunohistochemical studies of gap junctions, especially connexin 26 demonstrated high expression levels in the lateral cochlear wall and in the organ of Corti [15,16]. More than 150 different mutations in GJB2 have been reported to date, mainly described in autosomal-recessive and sporadic cases.…”

Section: Introductionmentioning

confidence: 99%