Unique and potent effects of acute ibogaine on zebrafish: The developing utility of novel aquatic models for hallucinogenic drug research

Cachat, Jonathan; Kyzar, Evan J.; Collins, Christopher; Gaikwad, Siddharth; Green, Jeremy; Roth, Andrew; El-Ounsi, Mohamed; Davis, Ari; Pham, Mimi; Landsman, Samuel; Stewart, Adam; Kalueff, Allan V.

doi:10.1016/j.bbr.2012.08.041

Cited by 99 publications

(74 citation statements)

References 77 publications

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“…For example, while serotonergic drugs do not generally evoke circling behavior in adult zebrafish, glutamatergic NMDA antagonists ketamine, MK-801, and PCP all induce overt circling in both zebrafish and rodent models (see refs 71, 101, and 157 for details). Although ibogaine was not active on zebrafish circling, 70 salvinorin A was reported to produce circling-like behaviors, 41 suggesting that opiodiergic mechanisms may also be involved in hallucinogenic-induced circling behavior in zebrafish models. There are almost no published studies on the effects of the main classes of hallucinogenic drugs on circling behavior in larval zebrafish, necessitating future testing.…”

Section: ■ Modeling Hallucinogenic Drug Action In Zebrafishmentioning

confidence: 96%

“…The effects of MK-801, PCP, and ketamine on anxiety-like behavior seem to be in line with clinical and rodent literature that generally shows anxiolytic-like effects evoked by NMDA antagonism; 102−115 also see our recent data on anxiolytic-like profile in zebrafish evoked by another NMDA antagonist, kynurenic acid. 116 Interestingly, while ibogaine-treated zebrafish demonstrated no significant changes in time in the top, transitions to the top, and freezing duration, the drug elicited an anxiolyticlike phenotype in zebrafish by decreasing latency to the top (also note increased erratic movement and freezing bouts 70 ). Since ibogaine possesses "mixed" serotonergic and glutamatergic properties, this observation is generally consistent with behavioral effects in zebrafish exposed to other serotonergic and glutamatergic drugs discussed above ( Table 2).…”

Section: ■ Modeling Hallucinogenic Drug Action In Zebrafishmentioning

confidence: 97%

“…The only study screening ketamine effects in larval zebrafish, 158 however, did report aberrant circling-like (looplike) swimming, further paralleling adult fish findings discussed above. Given the similarity of observed drug-induced "circling" behavior across various species (see ref 70 for discussion), zebrafish appear to mimic specific neurological phenotypes evoked by selected hallucinogenic drugs in various nonfish studies.…”

Section: ■ Modeling Hallucinogenic Drug Action In Zebrafishmentioning

confidence: 99%

“…63 These studies have developed detailed 3D-based approaches to phenotyping of zebrafish motor and anxiety-related behaviors, offering an innovative high-throughput data-dense methodology for automated visualization and quantification of fish swimming activity in both X, Y, Z (spatial) and X, Y, Time (spatiotemporal) coordinates. The use of 3D reconstruction of movement patterns (see Figure 1 for example) to study hallucinogenic drugs 66,70 enables a more precise deconstruction of zebrafish behavior affected by various agents. As rodent models used in neurobehavioral research are mainly based on 2D movement, zebrafish paradigms offer an increased dimensionality of behavioral phenotyping.…”

Section: ■ Future Directions: Where Next?mentioning

confidence: 99%

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Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds

Neelkantan

Mikhaylova

Stewart

et al. 2013

ACS Chem. Neurosci.

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Among different classes of psychotropic drugs, hallucinogenic agents exert one of the most prominent effects on human and animal behaviors, markedly altering sensory, motor, affective, and cognitive responses. The growing clinical and preclinical interest in psychedelic, dissociative, and deliriant hallucinogens necessitates novel translational, sensitive, and high-throughput in vivo models and screens. Primate and rodent models have been traditionally used to study cellular mechanisms and neural circuits of hallucinogenic drugs' action. The utility of zebrafish (Danio rerio) in neuroscience research is rapidly growing due to their high physiological and genetic homology to humans, ease of genetic manipulation, robust behaviors, and cost effectiveness. Possessing a fully characterized genome, both adult and larval zebrafish are currently widely used for in vivo screening of various psychotropic compounds, including hallucinogens and related drugs. Recognizing the growing importance of hallucinogens in biological psychiatry, here we discuss hallucinogenic-induced phenotypes in zebrafish and evaluate their potential as efficient preclinical models of drug-induced states in humans.

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Section: ■ Modeling Hallucinogenic Drug Action In Zebrafishmentioning

confidence: 96%

Section: ■ Modeling Hallucinogenic Drug Action In Zebrafishmentioning

confidence: 97%

Section: ■ Modeling Hallucinogenic Drug Action In Zebrafishmentioning

confidence: 99%

Section: ■ Future Directions: Where Next?mentioning

confidence: 99%

See 2 more Smart Citations

Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds

Neelkantan

Mikhaylova

Stewart

et al. 2013

ACS Chem. Neurosci.

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“…), a part of social behavior (e.g., display, fight or courtship), 42 as well as a result of stress/sickness, or drug-evoked dispersion (skin darkening) or aggregation (paling) of melanophores. 85 Specific drugs (e.g., alcohol, ibogaine 86,87 ) evoke robust skin darkening in adult zebrafish, while some factors (e.g., cold exposure, pathogens) can evoke paling (e.g., sickness behavior). Coloration response can be assessed manually (by visual inspection) or using automated (luminescence-based) tools.…”

Section: Aggregation Behaviormentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

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Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish 'do', and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which collectively will contribute to better integration of biological data within and across species.

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Emotional behavior in aquatic organisms? Lessons from crayfish and zebrafish

Abreu

Maximino

Banha

et al. 2019

J of Neuroscience Research

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Experimental animal models are a valuable tool to study the neurobiology of emotional behavior and mechanisms underlying human affective disorders. Mounting evidence suggests that various aquatic organisms, including both vertebrate (e.g., zebrafish) and invertebrate (e.g., crayfish) species, may be relevant to study animal emotional response and its deficits. Ideally, model organisms of disease should possess considerable genetic and physiological homology to mammals, display robust behavioral and physiological responses to stress, and should be sensitive to a wide range of drugs known to modulate stress and affective behaviors. Here, we summarize recent findings in the field of zebrafish‐ and crayfish‐based tests of stress, anxiety, aggressiveness and social preference, and discuss further perspectives of using these novel model organisms in translational biological psychiatry. Outlining the remaining questions in this field, we also emphasize the need in further development and a wider use of crayfish and zebrafish models to study the pathogenesis of affective disorders.

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Unique and potent effects of acute ibogaine on zebrafish: The developing utility of novel aquatic models for hallucinogenic drug research

Cited by 99 publications

References 77 publications

Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds

Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

Emotional behavior in aquatic organisms? Lessons from crayfish and zebrafish

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