Unilateral nevoid acanthosis nigricans: Uncommon variant of a common disease

Das, Anupam; Bhattacharya, S N; Kumar, Piyush; Gayen, Tirthankar; Roy, Kaushik; Das, Nilay Kanti; Gharami, Ramesh Chandra

doi:10.4103/2229-5178.144529

Cited by 9 publications

(9 citation statements)

References 10 publications

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“…Unilateral nevoid AN (UNAN) has a morphology similar to classical AN but is distributed unilaterally over a localized area and typically appears in childhood 16 …”

Section: Introductionmentioning

confidence: 99%

Acanthosis nigricans: A review

Das

Datta²,

Kassir

et al. 2020

J of Cosmetic Dermatology

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Background Acanthosis nigricans (AN) is a cutaneous disorder characterized by symmetric velvety hyperpigmented plaques on intertriginous areas like axilla, neck, inframammary, and groin. Aims To summarize the pathophysiology and classification of AN, provide an update of diagnostic testing strategies, and describe the current therapeutic options described so far in the literature for this disease. Methods A comprehensive english language literature search across multiple databases (PubMed, EMBASE, MEDLINE, and Cochrane) for keywords (alone and in combination) was performed. MeSH as well as non‐MeSH terms such as “acanthosis nigricans,” “classification,” “pathophysiology,” “diagnosis,” “treatment,” “topical drugs,” “systemic drugs,” “chemical peeling,” and “lasers” were taken into consideration. Results The pathophysiology of AN revolves around a multifactorial stimulation of proliferation of epidermal keratinocytes and dermal fibroblasts. Various types of AN include benign, obesity‐associated, syndromic, malignant, acral, unilateral, medication‐induced, and mixed‐type. Homeostasis model assessment‐insulin resistance (HOMA‐IR) is a good tool for assessment of insulin resistance. Management involves general measures (weight reduction and addressing the underlying cause, if any), topical drugs (retinoids, vitamin D analogs, and keratolytics), oral drugs (retinoids and insulin sensitizers), chemical peels (trichloroacetic acid), and lasers (Long pulsed alexandrite, fractional 1550‐nm erbium fiber, and CO2). Conclusion Acanthosis nigricans is a treatable condition; however, complete cure and disappearance of lesions are difficult to achieve. Weight reduction is the most scientific and practical management strategy. Long‐term studies and further research is warranted in the pathophysiology and treatment of this common condition.

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“…Unilateral nevoid AN (UNAN) has a morphology similar to classical AN but is distributed unilaterally over a localized area and typically appears in childhood 16 …”

Section: Introductionmentioning

confidence: 99%

Acanthosis nigricans: A review

Das

Datta²,

Kassir

et al. 2020

J of Cosmetic Dermatology

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“…Other clinical differentials include linear epidermal nevus, ichthyosis hystrix and confluent and reticulate papillomatosis. [5] The course of UNAN is benign. Our patient's main concern was cosmetic appearance of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Nevoid Acanthosis Nigricans - A rare case and successful treatment using fractional CO₂ laser

Gautam

Kumar

Ghuse

2023

IJPGD

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Nevoid acanthosis nigricans is a rare variant of acanthosis nigricans that may develop at birth or before puberty. An 18-year-old boy with a lean built presented with asymptomatic hyperpigmented lesion on the left lateral aspect of the trunk since 15 years of age. There was no systemic involvement. The diagnosis of unilateral nevoid acanthosis nigricans variant was made which was confirmed by dermoscopy and histopathology.

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“…The natural history of this condition is an insidious zosteriform appearance of skin lesions over few months around puberty and then it attains stability with no tendency for resolution. [ 3 ] The first clinical description of this clinical entity was published in 1991 when it was observed in a case of neurofibromatosis. [ 4 ] According to literature, this condition has been included in the syndromic variants of acanthosis nigricans or in the “other” nonspecific causes of acanthosis nigricans.…”

Section: Discussionmentioning

confidence: 99%