Acanthosis nigricans: A review

Das, Anupam; Datta, Debatri; Kassir, Martin; Wollina, Uwe; Galadari, Hassan; Lotti, Torello; Jafferany, Mohammad; Grabbe, Stephan; Goldust, Mohamad

doi:10.1111/jocd.13544

Cited by 54 publications

(74 citation statements)

References 70 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Especially, children who develop acanthosis nigricans are at a higher risk of having type 2 diabetes. In rare cases, acanthosis nigricans can be a warning sign of cancers in certain organs including the stomach and liver [49].…”

Section: Acanthosis Nigricansmentioning

confidence: 99%

A Molecular Perspective on the Potential Benefits of Metformin for the Treatment of Inflammatory Skin Disorders

Chang

Choi

2020

IJMS

View full text Add to dashboard Cite

Due to its anti-hyperglycemic effect, metformin is the first-line medication for the treatment of type 2 diabetes, particularly in people who are obese. However, metformin is a drug with a very wide range of pharmacological properties and reports of its therapeutic effect on diseases including inflammation and cancer are increasing. Numerous research groups have reported that metformin has beneficial effects on a variety of inflammatory skin disorders including psoriasis, acanthosis nigricans, acne, hidradenitis suppurativa, and allergic contact dermatitis. According to these reports, in addition to the well-known action of metformin, that is, its anti-hyperglycemic effect, NF-kB inhibition and the resulting alteration to the cytokine network may be the potential targets of metformin. Its anti-hyperandrogenism effect has also been confirmed as the major action of metformin in some inflammatory skin diseases. Moreover, novel regulatory mechanisms, including autophagy and antioxidant processes, have been suggested as promising mechanisms of action for metformin in inflammatory skin disorders.

show abstract

Section: Acanthosis Nigricansmentioning

confidence: 99%

A Molecular Perspective on the Potential Benefits of Metformin for the Treatment of Inflammatory Skin Disorders

Chang

Choi

2020

IJMS

View full text Add to dashboard Cite

show abstract

“…There is some added difficulty in assigning causality to the reported drugs due to confounding factors such as obesity, concomitant endocrinologic disorders, and co‐existing malignancy and other medical conditions for which the drugs were prescribed 31,46 . This was shown in the reported patients taking testosterone but also had diabetes mellitus and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Drug‐induced acanthosis nigricans: A systematic review and new classification

Mourad

Haber

2021

Dermatologic Therapy

View full text Add to dashboard Cite

Drug-induced acanthosis nigricans is an uncommon subtype of acanthosis nigricans and the data on this topic is not well understood by clinicians as it is presently limited in the literature. Previous reports of drug-induced acanthosis nigricans have simply consisted of a list of drugs possibly implicated in causing acanthosis nigricans. Several drugs listed are based on single case reports without biopsy confirmation, report of clearing on stopping the drug or reporting on whether acanthosis nigricans recurred with drug rechallenge. A comprehensive literature search was conducted using PubMed, EMBASE(Ovid), Cochrane Library, Scopus, and Web of Science electronic databases. The authors screened the initial result of the search strategy by title and abstract using the following inclusion criteria: eligible studies included those with patients who developed acanthosis nigricans secondary to a drug. This study is the first to comprehensively review the drugs that have been implicated in the development of acanthosis nigricans. A total of 38 studies were included in the systematic review, and a total of 13 acanthosis nigricans inducing drugs were identified. Nicotinic acid and insulin were the two most significant drugs that were reported to cause acanthosis nigricans. By using the results of this study, we created a revised classification system of drug-induced acanthosis nigricans which can be used as a concise framework for clinicians to refer to.

show abstract

“…Among patients with POS, AN is associated with higher free testosterone levels, which may be explained by the association with hyperinsulinaemia, which can promote ovarian thecal androgen secretion and inhibit hepatic synthesis of sex hormone-binding globulin, as in the case of our patient. 3 AN is a manageable condition, however, the complete reversion of the lesions is difficult to achieve. Although weight reduction is acknowledged as the most efficient strategy to tackle AN, this report suggests that metformin and pioglitazone should be considered in order to improve insulin sensitivity and endocrine and metabolic indices, which may have a visible impact on AN extension.…”

Section: Descriptionmentioning

confidence: 99%