Unilateral lattice dystrophy in an elderly patient

Sridhar, Magadi Gopalakrishna; Pandrowala, Hijab; Rao, Gullapalli N

doi:10.1038/sj.eye.6700140

Cited by 4 publications

(4 citation statements)

References 14 publications

(17 reference statements)

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“…To date, only lattice corneal dystrophy has been reported with unilateral presentation. [2][3][4][5][6][7][8] In many of these reports, questions remain as to whether the reported unilateral presentations of lattice corneal dystrophy represent truly unilateral disease manifestations or whether they have simply been asymmetric presentations of bilateral disease. In some cases, a presumed unilateral manifestation was confirmed to be bilateral either with longer follow-up or with more detailed analysis beyond clinical examination, including in vivo confocal microscopy.…”

Section: Discussionmentioning

confidence: 99%

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Unilateral Granular Type 2 Corneal Dystrophy With Exacerbation After LASIK

Bostan,

Randleman

2024

Cornea

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Purpose: The aim of this study was to report a case of unilateral granular corneal dystrophy type 2 (GCD2) with exacerbation after bilateral laser in situ keratomileusis (LASIK). Methods: Clinical evaluation, Scheimpflug imaging, anterior segment optical coherence tomography (AS-OCT), cytology, and genetic testing were used to confirm the diagnosis of unilateral GCD2 with exacerbation after bilateral LASIK. Detailed literature review for possible unilateral GCD2 presentations was performed. Results: A 54-year-old White woman presented with blurred vision in her left eye and a history of bilateral LASIK performed 8 years before. Examination revealed dense opacities in the left cornea only, which were confirmed to be confined to the LASIK interface and adjacent corneal stromal tissue, as determined by AS-OCT. The patient underwent flap lift, interface debris removal, and stromal bed phototherapeutic keratectomy. Cytological analysis showed eosinophilic corneal stromal deposits that stained with trichrome stain and were congophilic on Congo red stain. Genetic testing was positive for heterozygous GCD2 transforming growth factor β–induced gene (TGFBI), c.371G>A, p.R124H mutation. There were no opacities identifiable in the right eye on serial slit-lamp examination, Scheimpflug imaging, or OCT imaging at 4 or 8 years after bilateral LASIK. Literature review failed to identify any previous reports of unilateral GCD2. Conclusions: This is the first known reported case of unilateral granular corneal dystrophy type 2. LASIK is contraindicated in eyes with corneal stromal dystrophies related to mutations in TGFBI as both flap creation and laser ablation can exacerbate visually significant opacity formation. Scheimpflug and AS-OCT imaging are useful to identify opacities in GCD2.

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Section: Discussionmentioning

confidence: 99%

“…1 These dystrophies almost exclusively present bilaterally, although unilateral or asymmetric presentations of lattice corneal dystrophy have been reported. [2][3][4][5][6][7][8] To date, there have been no reports of unilateral presentation of GCD2.…”

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confidence: 99%

Unilateral Granular Type 2 Corneal Dystrophy With Exacerbation After LASIK

Bostan,

Randleman

2024

Cornea

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“…These two cases were caused by the Leu 527 Arg mutation of TGFBI gene. Sridhar et al (2002)reported a case of unilateral LCD type 1 which presented in the ninth decade. Sridhar et al(2001) concluded that unilateral LCD with lesions resembling LCD type I can occur in two clinical types.…”

Section: Discussionmentioning

confidence: 99%

Unilateral lattice corneal dystrophy in a young female: A unique case report

2017

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Background: Unilateral lattice corneal dystrophy is a rare entity. Objective: To highlight the evidence of unilateral lattice corneal dystrophy in a young female. Case: A young 28 years old female presented to the outpatient department of Ophthalmology with slowly progressive diminution of vision in left eye for one month. On ophthalmological examination best corrected visual acuity (BCVA) was 20/20 and 20/40 with refractive error of plano and -0.75D Cyl @30 for right and left eye respectively. Ocular examination of right eye was unremarkable. On slit lamp examination, left eye showed multiple radial lattice lines in branching spider like pattern in the temporal cornea with pupillary margin involvement. The lattice pattern was confined to anterior to midstroma of the cornea with intact epithelium and unremarkable endothelium. The lesions did not involve the limbus. These lattice lines were prominent on retroillumination. In temporal quadrant near pupillary margin a small radial nebulomacular corneal opacity was seen without any corneal vascularisation or edema. The anterior chamber was deep and quiet. Corneal sensations were markedly reduced. Intraocular pressure was 10 and 12mmHg for right and left eye respectively with noncontact tonometry. Fundus examination was unremarkable. Family history and systemic history was negative. Optical coherence tomography(OCT) showed hyperreflective material in midstoma confirmed the diagnosis of unilateral lattice corneal dystrophy(LCD) with an apparently healthy fellow eye.

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“…3 In addition, the accepted means of differentiating between the corneal dystrophies on the basis of characteristic clinical features has been challenged by the observance of significant interfamilial and even intrafamilial phenotypic variability among affected individuals sharing a common mutation. [4][5][6] Even the definition of a corneal dystrophy has been challenged in this new era of molecular genetics, as we are now able to confirm the diagnosis of a corneal dystrophy in cases associated with an atypical phenotype, such as unilateral dystrophies, [7][8][9][10][11] dystrophies that involve more than a single layer of the cornea, 5,12 and dystrophies that are associated with extraocular involvement. [12][13][14] Identification of the genetic basis of the corneal dystrophies and characterization of the expressed protein product have led to insights such as the fact that the transforming growth factor ␤-induced protein (TGFBI) dystrophies, which involve the Bowman layer and stroma, may actually be of an epithelial genesis.…”

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confidence: 99%

Elucidating the Molecular Genetic Basis of the Corneal Dystrophies

Aldave¹

2007

Arch Ophthalmol

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Unilateral lattice dystrophy in an elderly patient

Cited by 4 publications

References 14 publications

Unilateral Granular Type 2 Corneal Dystrophy With Exacerbation After LASIK

Unilateral Granular Type 2 Corneal Dystrophy With Exacerbation After LASIK

Unilateral lattice corneal dystrophy in a young female: A unique case report

Elucidating the Molecular Genetic Basis of the Corneal Dystrophies

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