Unilateral lattice corneal dystrophy in a young female: A unique case report

Abstract

Background: Unilateral lattice corneal dystrophy is a rare entity. Objective: To highlight the evidence of unilateral lattice corneal dystrophy in a young female. Case: A young 28 years old female presented to the outpatient department of Ophthalmology with slowly progressive diminution of vision in left eye for one month. On ophthalmological examination best corrected visual acuity (BCVA) was 20/20 and 20/40 with refractive error of plano and -0.75D Cyl @30 for right and left eye respectively. Ocular examination of right eye was unremarkable. On slit lamp examination, left eye showed multiple radial lattice lines in branching spider like pattern in the temporal cornea with pupillary margin involvement. The lattice pattern was confined to anterior to midstroma of the cornea with intact epithelium and unremarkable endothelium. The lesions did not involve the limbus. These lattice lines were prominent on retroillumination. In temporal quadrant near pupillary margin a small radial nebulomacular corneal opacity was seen without any corneal vascularisation or edema. The anterior chamber was deep and quiet. Corneal sensations were markedly reduced. Intraocular pressure was 10 and 12mmHg for right and left eye respectively with noncontact tonometry. Fundus examination was unremarkable. Family history and systemic history was negative. Optical coherence tomography(OCT) showed hyperreflective material in midstoma confirmed the diagnosis of unilateral lattice corneal dystrophy(LCD) with an apparently healthy fellow eye.

Unilateral Granular Type 2 Corneal Dystrophy With Exacerbation After LASIK

“…To date, only lattice corneal dystrophy has been reported with unilateral presentation. [2][3][4][5][6][7][8] In many of these reports, questions remain as to whether the reported unilateral presentations of lattice corneal dystrophy represent truly unilateral disease manifestations or whether they have simply been asymmetric presentations of bilateral disease. In some cases, a presumed unilateral manifestation was confirmed to be bilateral either with longer follow-up or with more detailed analysis beyond clinical examination, including in vivo confocal microscopy.…”

“…1 These dystrophies almost exclusively present bilaterally, although unilateral or asymmetric presentations of lattice corneal dystrophy have been reported. [2][3][4][5][6][7][8] To date, there have been no reports of unilateral presentation of GCD2.…”

Contact lens induced bacterial keratitis in LCD II: Management and multimodal imaging: a case report and review of literature

“…1 It is a bilateral slowly progressive disease, although some cases were reported unilateral. 2 Lattice corneal dystrophy type I (classic type) is a primary amyloidosis localized to the corneas only, while lattice corneal dystrophy type II (LCD II), gelsolin type, is a systemic amyloidosis associated with a classic triad of progressive bilateral facial paralysis, loose skin (cutis laxa) and lattice dystrophy. 3 LCD II was first described by ophthalmologist Jouko Meretoja in 1969.…”

“…4,5 Other LCD variants previously designated type IIIA, I/IIIA, IV, and polymorphic amyloidosis were described. 1,2 LCD II is also known as familial amyloidosis -Finnish type, familial amyloid polyneuropathy type IV, systemic amyloidosis type V, or AGel amyloidosis. It is an autosomal dominant inherited amyloidosis that has been mapped to chromosome 9 and has 100% penetrance with variable expressivity.…”