Unilateral Dermatomal Superficial Telangiectasia Overlapping Becker's Melanosis

Wagner, Richard F.; Grande, Donald J.; Bhawan, Jag; Hellerstein, Marc K.; Longcope, Christopher

doi:10.1111/j.1365-4362.1989.tb02535.x

Cited by 15 publications

(7 citation statements)

References 8 publications

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“…Telangiectasia in cases of UNT with no hormonal abnormality has been hypothesized to be due to mosaicism of cell populations arising by somatic mutation during embryologic development (16). Furthermore, some cases of UNT accompanied by Becker nevus have also been explained by mosaicism (17).…”

Section: Discussionmentioning

confidence: 99%

Unilateral Nevoid Telangiectasia

Karakaş

Durdu

Sönmezoğlu

et al. 2004

The Journal of Dermatology

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Unilateral nevoid telangiectasia is a cutaneous condition consisting of congenital or acquired patches of superficial telangiectases in a unilateral linear distribution. Unilateral nevoid telangiectasia has been associated with elevations of blood estrogen levels and/or an increased number of estrogen receptors in the involved skin. We present a hepatitis-B carrier case with unilateral nevoid telangiectasia on the face and the right side of the neck; she had normal blood estrogen and a normal number of estrogen receptors in the involved skin.

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Section: Discussionmentioning

confidence: 99%

Unilateral Nevoid Telangiectasia

Karakaş

Durdu

Sönmezoğlu

et al. 2004

The Journal of Dermatology

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“…The genetic basis of this syndrome is not clear but it has been proposed that the phenotype results from loss of heterozygosity for the underlying allele [Happle, 1995]. Interestingly, Wagner et al [1989] have observed a case of Becker nevus arranged in close proximity to unilateral nevoid teleangiectasia. This association has been taken as a possible example of twin spotting, implying allelic loss by somatic recombination [Happle, 1993].…”

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confidence: 99%

Becker nevus syndrome

1997

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The new term Becker nevus syndrome is proposed for a phenotype characterized by the presence of a particular type of organoid epithelial nevus showing hyperpigmentation, increased hairiness and hamartomatous augmentation of smooth muscle fibers, and other developmental defects such as ipsilateral hypoplasia of breast and skeletal anomalies including scoliosis, spina bifida occulta, or ipsilateral hypoplasia of a limb. The present review includes 23 cases that can be categorized under this designation. The Becker nevus syndrome usually occurs sporadically. The associated anomalies tend to show a definite regional correspondence, suggesting a common origin from an early postzygotic mutation.

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“…38,[88][89][90][91][92][93] The second hypothesis states that BNS is a hormone-dependent disorder; this theory is based on the increased number of androgen receptors in the affected areas: for this reason, the appearance of lesions is more frequent in puberty, and alteration such as hypertrichosis and acneiform eruptions are restricted to the regions. 94 As reported above, BN is an androgen-sensitive lesion. It presents with increased androgen receptor mRNA and androgen receptors, as well as increased receptor positivity in basal keratinocytes and dermal fibroblasts.…”

Section: Pathogenesis and Molecular Geneticsmentioning

confidence: 73%

Becker's Nevus Syndrome

et al. 2018

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The simultaneous occurrence of a patch of light or dark brown hyperpigmentation with hypertrichosis (Becker's nevus) together with (usually ipsilateral) soft tissues hypoplasia (especially breast, in women) and underlying skeletal anomalies (i.e., vertebral hypoplasia, scoliosis, pectus carinatum or excavatum) represents the Becker's nevus syndrome (BNS) phenotype. It was first described (as a single cutaneous lesion) by Becker in 1949 and then associated with the surrounding musculoskeletal disorders. The syndrome has also been reported as pigmentary hairy epidermal nevus syndrome. Less than 100 cases have been reported in the literature, with a slightly higher incidence in females and only few familiar cases: paradominant postzygotic mutations and/or an androgen-dependent hyperactivation have been reported as the causes of the diseases.The extracutaneous lesions are congenital and nonprogressive, and the natural history of the Becker's nevus is the same as that of isolated nevi: in prepubertal boys, the pigmentation may be less intense and the hairiness may be absent or mild, as occurs in women, whereas in men, there is an increase of hairiness after puberty. The treatment is essentially cosmetic, and potential therapeutic options include electrolysis, waxing, makeup, or laser.

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Unilateral Dermatomal Superficial Telangiectasia Overlapping Becker's Melanosis

Cited by 15 publications

References 8 publications

Unilateral Nevoid Telangiectasia

Unilateral Nevoid Telangiectasia

Becker nevus syndrome

Becker's Nevus Syndrome

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