Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex

Liu, Jing; Huang, Xinyi; Zhang, Jiping

doi:10.3389/fnins.2021.762337

Cited by 3 publications

(3 citation statements)

References 63 publications

(103 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A contralateral transmission of the direct sound is also present with medium AC components, but at a lower level. Another possible explanation is a possible deprivation of the auditory pathway attributable to prolonged high-level conductive HL, especially with unusable conventional hearing aids prior to Osia fitting, such as in patients with auditory canal atresia [ 7 , 21 ]. Our results show a negative dependence of speech comprehension with Osia on ABG and thus they differ from those reported by Mylanus et al.…”

Section: Discussionmentioning

confidence: 99%

Prediction of postoperative speech comprehension with the transcutaneous partially implantable bone conduction hearing system Osia®

Arndt,

Wesarg,

Aschendorff

et al. 2023

HNO

View full text Add to dashboard Cite

Background The active transcutaneous, partially implantable osseointegrated bone conduction system Cochlear™ Osia® (Cochlear, Sydney, Australia) has been approved for use in German-speaking countries since April 2021. The Osia is indicated for patients either having conductive (CHL) or mixed hearing loss (MHL) with an average bone conduction (BC) hearing loss of 55 dB HL or less, or having single-sided deafness (SSD). Objectives The aim of this retrospective study was to investigate the prediction of postoperative speech recognition with Osia® and to evaluate the speech recognition of patients with MHL and in particular an aided dynamic range of less than 30 dB with Osia®. Materials and methods Between 2017 and 2022, 29 adult patients were fitted with the Osia®, 10 patients (11 ears) with CHL and 19 patients (25 ears) with MHL. MHL was subdivided into two groups: MHL‑I with four-frequency pure-tone average in BC (BC-4PTA) ≥ 20 dB HL and < 40 dB HL (n = 15 patients; 20 ears) vs. MHL-II with BC-4PTA ≥ 40 dB HL (n = 4 patients; 5 ears). All patients tested a bone conduction hearing device on a softband preoperatively. Speech intelligibility in quiet was assessed preoperatively using the Freiburg monosyllabic test in unaided condition, with the trial BCHD preoperatively and with Osia® postoperatively with Osia®. The maximum word recognition score (mWRS) unaided and the word recognition score (WRS) with the test system at 65 dB SPL were correlated with the postoperative WRS with Osia® at 65 dB SPL. Results Preoperative prediction of postoperative outcome with Osia® was better using the mWRS than by the WRS at 65 dB SPL with the test device on the softband. Postoperative WRS was most predictive for patients with CHL and less predictable for patients with mixed hearing loss with BC-4PTA ≥ 40 dB HL. For the test device on a softband, the achievable outcome tended to a minimum, with the mWRS tending to predict the realistically achievable outcome. Conclusion Osia® can be used for the treatment of CHL and MHL within the indication limits. The average preoperative bone conduction hearing threshold also provides an approximate estimate of the postoperative WRS with Osia®, for which the most accurate prediction is obtained using the preoperative mWRS. Prediction accuracy decreases from a BC-4PTA of ≥ 40 dB HL.

show abstract

Section: Discussionmentioning

confidence: 99%

Prediction of postoperative speech comprehension with the transcutaneous partially implantable bone conduction hearing system Osia®

Arndt,

Wesarg,

Aschendorff

et al. 2023

HNO

View full text Add to dashboard Cite

show abstract

“…Currently, the mechanism underlying the development of binaural advantage in temporal processing remains unclear. Previous studies have shown that binaural processing undergoes postnatal refinement in the auditory cortex ( Liu et al, 2021 ), and monaural hearing loss disrupts the development of binaural selectivity both in the auditory midbrain and cortex ( Popescu and Polley, 2010 ). We speculate that developmental changes in binaural advantage for temporal processing are related to postnatal development and refinement of binaural processing.…”

Section: Discussionmentioning

confidence: 99%

“…The hardware of the workstation for presenting acoustic stimuli included a multifunction processor (RX6-A5), a stereo power amplifier (SA1), and two multi-field magnetic speakers (MF1). The acoustic stimuli were delivered to the ears of the rats via a close-field system similar to our previous studies ( Liu et al, 2021 ). Briefly, the MF1 speakers were incorporated internal parabolic cones and coupled to the ears through PVC plastic tubes (9.5 cm long, 1/16 inch ID, 1/8 inch OD, and 1/32 inch wall thickness) leading to the ear canals.…”

Section: Methodsmentioning

confidence: 99%

Binaural advantages in sound temporal information processing by neurons in the rat inferior colliculus

Li,

Zhang

2023

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

Previous studies on the advantages of binaural hearing have long been focused on sound localization and spatial stream segregation. The binaural advantages have also been observed in speech perception in reverberation. Both human speech and animal vocalizations contain temporal features that are critical for speech perception and animal communication. However, whether there are binaural advantages for sound temporal information processing in the central auditory system has not been elucidated. Gap detection threshold (GDT), the ability to detect the shortest silent interval in a sound, has been widely used to measure the auditory temporal resolution. In the present study, we determined GDTs of rat inferior collicular neurons under both monaural and binaural hearing conditions. We found that the majority of the inferior collicular neurons in adult rats exhibited binaural advantages in gap detection, i.e., better neural gap detection ability in binaural hearing conditions compared to monaural hearing condition. However, this binaural advantage in sound temporal information processing was not significant in the inferior collicular neurons of P14-21 and P22-30 rats. Additionally, we also observed age-related changes in neural temporal acuity in the rat inferior colliculus. These results demonstrate a new advantage of binaural hearing (i.e., binaural advantage in temporal processing) in the central auditory system in addition to sound localization and spatial stream segregation.

show abstract

Prediction of speech understanding with the transcutaneous partially implantable bone conduction hearing system Osia®. German Version

Arndt,

Wesarg,

Aschendorff

et al. 2023

HNO

View full text Add to dashboard Cite

Zusammenfassung Hintergrund Das aktive transkutane, teilimplantierbare, osseointegrierte Knochenleitungssystem Cochlear™ Osia® (Fa. Cochlear, Sydney, Australien) ist seit April 2021 im deutschsprachigen Raum zugelassen. Das Osia ist für Patienten mit Schallleitungs- (SL-SH) oder kombinierter Schwerhörigkeit (komb-SH) mit einem mittleren Knochenleitungshörverlust von maximal 55 dB HL oder bei einseitiger Taubheit („single-sided deafness“, SSD) indiziert. Ziel der Arbeit Ziel dieser retrospektiven Untersuchung war es, die Prädiktion des postoperativen Sprachverstehens mit Osia zu untersuchen sowie die Ergebnisse des Sprachverstehens von Patienten mit komb-SH und einem geringen Dynamikbereich von weniger als 30 dB nach erfolgter Osia-Versorgung zu evaluieren. Material und Methoden Zwischen 2017 and 2022 wurden 29 erwachsene Patienten mit dem Osia versorgt, davon 10 Patienten (11 Ohren) mit SL-SH und 19 Patienten (25 Ohren) mit komb-SH. Die Patienten mit komb-SH wurden in 2 Gruppen aufgeteilt: komb-SH‑I mit über 4 Frequenzen gemittelter Hörschwelle in Knochenleitung („four-frequency pure-tone average“,(PTA4-KL)) ≥ 20 dB HL und < 40 dB HL (n = 15 Patienten, 20 Ohren) vs. komb-SH-II mit PTA4-KL ≥ 40 dB HL (n = 4 Patienten, 5 Ohren). Alle Patienten testeten präoperativ ein Knochenleitungsgerät am Softband. Präoperativ wurde das Sprachverstehen im Freiburger Einsilbertest unversorgt und mit Testsystem erfasst. Das maximale Einsilberverstehen (mEV) unversorgt und das Einsilberverstehen (EV) mit Testsystem bei 65 dB SPL wurde mit dem postoperativ erreichten EV mit Osia bei 65 dB SPL korreliert. Ergebnisse Die präoperative Vorhersage für das postoperative Ergebnis mit Osia war anhand des mEV mit höherer Varianzaufklärung als mit dem EV bei 65 dB SPL mit KL-Testgerät am Softband möglich. Das postoperative EV war am besten für die Patienten mit SL-SH und am schlechtesten für Patienten mit komb-SH mit einer PTA4-KL ≥ 40 dB HL vorhersagbar. Die Ergebnisse mit dem Testgerät am Softband zeigen eher das minimal erreichbare Ergebnis und das mEV eher das realistisch zu erreichende Ergebnis mit Osia. Schlussfolgerung Das Osia kann für die Versorgung von SL-SH und komb-SH unter Beachtung der Indikationsgrenzen eingesetzt werden. Auch die mittlere präoperative Knochenleitungshörschwelle liefert näherungsweise eine Abschätzung des postoperativen EV mit Osia, für das die genaueste Vorhersage anhand des präoperativen mEV erzielt wird. Die Vorhersagegenauigkeit reduziert sich ab einer PTA4-KL von ≥ 40 dB.

show abstract

Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex

Cited by 3 publications

References 63 publications

Prediction of postoperative speech comprehension with the transcutaneous partially implantable bone conduction hearing system Osia®

Prediction of postoperative speech comprehension with the transcutaneous partially implantable bone conduction hearing system Osia®

Binaural advantages in sound temporal information processing by neurons in the rat inferior colliculus

Prediction of speech understanding with the transcutaneous partially implantable bone conduction hearing system Osia®. German Version

Contact Info

Product

Resources

About