Unilateral and bilateral repetitive transcranial magnetic stimulation for treatment‐resistant late‐life depression

Trevizol, Alisson Paulino; Goldberger, Kyle; Mulsant, Benoit H.; Rajji, Tarek K.; Downar, Jonathan; Daskalakis, Zafiris J.; Blumberger, Daniel M.

doi:10.1002/gps.5091

Cited by 42 publications

(48 citation statements)

References 39 publications

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“…The effect of treatment is obvious initially, then, after a time, the drug gradually appears to "fail" [ 7 ]. Many new forms of physical therapy, such as using sound, light, electricity, and magnetism to act on certain parts of the body [ 6 , 7 , 8 , 9 ], have been used to induce sleep. Electricity and magnetism can also stimulate neurons in the functional areas of the brain; a special frequency of weak electricity and weak magnetic field causes the resonance phenomena to affect the discharge frequency of brain functional areas, which, in turn, induces sleep [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Microwave Treatment for Sleep Disorders and Classification of Sleep Stages Using Multi-Scale Entropy

Geng

Yang

Cai

et al. 2020

Entropy

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The aim of this study was to develop an integrated system of non-contact sleep stage detection and sleep disorder treatment for health monitoring. Hence, a method of brain activity detection based on microwave scattering technology instead of scalp electroencephalogram was developed to evaluate the sleep stage. First, microwaves at a specific frequency were used to penetrate the functional sites of the brain in patients with sleep disorders to change the firing frequency of the activated areas of the brain and analyze and evaluate statistically the effects on sleep improvement. Then, a wavelet packet algorithm was used to decompose the microwave transmission signal, the refined composite multiscale sample entropy, the refined composite multiscale fluctuation-based dispersion entropy and multivariate multiscale weighted permutation entropy were obtained as features from the wavelet packet coefficient. Finally, the mutual information-principal component analysis feature selection method was used to optimize the feature set and random forest was used to classify and evaluate the sleep stage. The results show that after four times of microwave modulation treatment, sleep efficiency improved continuously, the overall maintenance was above 80%, and the insomnia rate was reduced gradually. The overall classification accuracy of the four sleep stages was 86.4%. The results indicate that the microwaves with a certain frequency can treat sleep disorders and detect abnormal brain activity. Therefore, the microwave scattering method is of great significance in the development of a new brain disease treatment, diagnosis and clinical application system.

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Section: Introductionmentioning

confidence: 99%

A Novel Microwave Treatment for Sleep Disorders and Classification of Sleep Stages Using Multi-Scale Entropy

Geng

Yang

Cai

et al. 2020

Entropy

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“…There are insufficient data in the elderly group to comment if presence of treatment resistance, psychosis, cognitive impairment or medical comorbidities have any moderating effect in response to rTMS 42. In a recent study, Trevizol et al 47 had evaluated the efficacy of rTMS (bilateral and high frequency unilateral on left side) in older adults with treatment-resistant depression. Patients who received bilateral sequential rTMS were reportedly to have greater rate of response (40%) compared with unilateral and sham TMS groups 47.…”

Section: Introductionmentioning

confidence: 99%

“…In a recent study, Trevizol et al 47 had evaluated the efficacy of rTMS (bilateral and high frequency unilateral on left side) in older adults with treatment-resistant depression. Patients who received bilateral sequential rTMS were reportedly to have greater rate of response (40%) compared with unilateral and sham TMS groups 47. Hence, bilateral TMS can be a better choice to deal with treatment-resistant depression in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of repetitive transcranial magnetic stimulation in treatment-resistant depression: the evidence thus far

Somani

Kar

2019

Gen Psych

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Depression is a common mental disorder, which attributes to significant morbidity, disability and burden of care. A significant number of patients with depression still remain symptomatic after adequate trials of antidepressant treatment as well as psychotherapy, which is often referred to as treatment-resistant depression. Neuromodulation techniques—like electroconvulsive therapy, vagus nerve stimulation, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, may be useful augmenting techniques in depression, mostly recommended for treatment-resistant cases. Robust evidence exists regarding the efficacy of electroconvulsive therapy in the management of treatment-resistant depression; however, other techniques are understudied. TMS has been increasingly studied in various psychiatric disorders including depression. It has been approved by the US Food and Drug Administration for use in major depressive disorder. Over the past two decades, TMS has been studied in diverse groups of the population with depression using several research designs. This article gives an overview of the efficacy of repetitive TMS in treatment-resistant depression with the recent evidence.

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“…Trevizol and colleagues 27 an experience comparable with active rTMS. AE were only reported in the group treated with unilateral HF-rTMS; one patient reported headache and one patient reported insomnia.…”

Section: Randomized Controlled Trialsmentioning

confidence: 99%

Adverse events of repetitive transcranial magnetic stimulation in older adults with depression, a systematic review of the literature

Overvliet

Jansen

Balkom

et al. 2020

Int J Geriat Psychiatry

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Objective: In the last decade, repetitive transcranial magnetic stimulation (rTMS) has been introduced as a non-invasive neuromodulation therapy for depression. Little is known, however, about (serious) adverse events (AE) of rTMS in older adults with a depression. In this article, we want to study what is known about (serious) AE of rTMS in older adults (>60 years) with late-life depression (LLD). Methods: A systematic search has been performed according to the PRISMA guidelines in PubMed, EMBase and PsycInfo. We have screened 622 articles for eligibility. Eleven studies, evaluating 353 patients in total, were included in this review. Results: AE were reported in 12.4% of the older adults with a LLD treated with rTMS, serious AE in 1.5%. Headache (6.9%) and discomfort at the stimulation site (2.7%) are the most commonly reported AE. Serious AE reported are: psychiatric hospitalization (three times), a combination of posterior vitreous detachment and retinal tear, and increased suicide ideation (both once). Conclusions: rTMS in older adults with LLD was concluded overall to be safe due to the low frequency of AE reported in trials and observational studies. In case-reports, however, more serious AE have been described. To tailor use of rTMS in older adults with LLD, more research is needed in larger samples to optimize tolerance.

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Unilateral and bilateral repetitive transcranial magnetic stimulation for treatment‐resistant late‐life depression

Cited by 42 publications

References 39 publications

A Novel Microwave Treatment for Sleep Disorders and Classification of Sleep Stages Using Multi-Scale Entropy

A Novel Microwave Treatment for Sleep Disorders and Classification of Sleep Stages Using Multi-Scale Entropy

Efficacy of repetitive transcranial magnetic stimulation in treatment-resistant depression: the evidence thus far

Adverse events of repetitive transcranial magnetic stimulation in older adults with depression, a systematic review of the literature

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