Unilateral Adrenal Catecholamine Excess

Bauman, Arthur

doi:10.1001/archinte.1982.00340150177031

Cited by 3 publications

(11 citation statements)

References 7 publications

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“…In the case presented here, MIBG scanning was not conclusive. CT scanning showed only a slightly enlarged adrenal gland in one case, and localised a ‘tumour’ in two of the other seven patients in whom it was performed 6‐9 . CT scanning was not helpful in our case but was difficult to read because of an artefact created by surgical clips from a previous cholecystetomy.…”

Section: Discussionmentioning

confidence: 60%

“…Improving radiological techniques hold promise in making this diagnosis preoperatively but further studies are needed. Adrenal vein catheteristion was localising in all four cases in whom it was performed and may turn out to be the localisation study of choice 6,8,9 …”

Section: Discussionmentioning

confidence: 99%

“…In their case, no associated diseases were described. Unilateral or bilateral adrenal medullary hyperplasia outside the context of a MEN Type 2 syndrome has been described in 14 different cases 3‐10 …”

mentioning

confidence: 99%

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Unilateral Adrenal Medullary Hyperplasia: Another Form of Curable Hypertension?

Bailey

Herle

Giuliano

et al. 1999

Int J Clinical Practice

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SUMMARYA case of unilateral adrenal medullary hyperplasia is presented in a 49‐year‐old caucasian female without multiple endocrine neoplasia association. The patient presented with episodic hypertension and paroxysms suggesting an underlying phaeochromocytoma. Biochemical supported this diagnosis but no discrete tumour was found on preoperative localising studies or at the time of surgery. The patient underwent a unilateral adrenalectomy with confirming adrenal medullary hyperplasia with complete resolution of her symptoms for six months.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

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Unilateral Adrenal Medullary Hyperplasia: Another Form of Curable Hypertension?

Bailey

Herle

Giuliano

et al. 1999

Int J Clinical Practice

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“…The occurrence of unilateral adrenal medullary hyperplasia not associated with familial or multiple endocrine neoplasia is extremely rare and has been documented in several cases (Montalbano et al, 1962;Rudy et al, 1980;Bauman, 1982;Yoshio et al, 1989). In these rare cases the diagnosis of pheochromocytoma was made following routine biochemical diagnostic tests, i.e.…”

mentioning

confidence: 99%

“…increased 24-hour urine content of vanillylmandelic acid (VMA) or urine catecholamines excretion. In most of these cases, surgical exploration revealed unilateral adrenal medullary hyperplasia (Montalbano et al, 1962;Bauman, 1982).…”

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confidence: 99%

Pheochromocytoma due to unilateral adrenal medullary hyperplasia

Qupty¹,

Ishay²,

Peretz

et al. 1997

Clinical Endocrinology

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We describe two male patients, aged 17 and 47 years, with clinical and biochemical features of pheochromocytoma. Both patients had normal-sized adrenal glands on abdominal CT scan and abnormal unilateral uptake of I-123 metaiodobenzylguanidine (MIBG) on scintigraphy. The surgical adrenalectomy revealed normal macroscopic glands in both patients. Histological examination showed adrenal medullary hyperplasia with adrenal cortico-medullary ratios of 2:1 and 4:1. Unilateral adrenalectomy resulted in amelioration of symptoms and normalization of catecholamines excretion. DNA examination for RET protooncogene revealed no mutations in exons 10, 11, 13, 14 and 16. Our results suggest that diffuse adrenal medullary hyperplasia may be the initial pathological change in the adrenal gland leading, subsequently, to the development of nodular hyperplasia and adrenal medullary tumor. These results indicate that the syndrome of pheochromocytoma may occur as an unilateral adrenal medullary hyperplasia in patients without evidence for multiple endocrine neoplasia.

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Adrenal medullary hyperplasia mimicking pheochromocytoma

2020

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A 59-year-old woman, a known case of hypertension, was incidentally diagnosed with a large right-sided adrenal mass. Investigations for a functional adrenal lesion resulted in very high preoperative norepinephrine levels. A right adrenalectomy was performed. Histology showed adrenal medullary hyperplasia (AMH). AMH is a rare diagnosis and its incidence is poorly documented in the literature. This is a benign entity which resembles pheochromocytoma (PCC) in both clinical and biochemical manner. AMH is usually bilateral and may occur in isolation or in association with PCC. In fact, some authors consider it to be a precursor to PCC. Thus, these patients need long-term follow-up in view of the risk of development of PCC later.

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Unilateral Adrenal Catecholamine Excess

Cited by 3 publications

References 7 publications

Unilateral Adrenal Medullary Hyperplasia: Another Form of Curable Hypertension?

Unilateral Adrenal Medullary Hyperplasia: Another Form of Curable Hypertension?

Pheochromocytoma due to unilateral adrenal medullary hyperplasia

Adrenal medullary hyperplasia mimicking pheochromocytoma

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