P. COVID-19 vaccination and patients with psoriasis under biologics: real-life evidence on safety and effectiveness from Italian vaccinated healthcare workers.

True hermaphroditism represents only 5% cases of all of disorders of sexual differentiation (DSD) and usually present in early childhood with ambiguous genitalia. Occasionally, cases might present later on in adolescence with problems of sexual maturation. Our case report presents a true hermaphrodite with normal male phenotype that presented as a left testicular mass, two years after being diagnosed with Sertoli cell only syndrome in the contralateral testis. Histological examination of the left testis showed ovarian, fallopian tube, myometrial, endometrial, and epididymal tissue. This combination of findings is found in approximately one-third of true hermaphrodites, but it is very rare to present clinically as an inguinoscrotal mass.

A 59-year-old woman, a known case of hypertension, was incidentally diagnosed with a large right-sided adrenal mass. Investigations for a functional adrenal lesion resulted in very high preoperative norepinephrine levels. A right adrenalectomy was performed. Histology showed adrenal medullary hyperplasia (AMH). AMH is a rare diagnosis and its incidence is poorly documented in the literature. This is a benign entity which resembles pheochromocytoma (PCC) in both clinical and biochemical manner. AMH is usually bilateral and may occur in isolation or in association with PCC. In fact, some authors consider it to be a precursor to PCC. Thus, these patients need long-term follow-up in view of the risk of development of PCC later.

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This is a brief report of possibly the first documented case of retinal phototoxicity secondary to occupational use of the light microscope with visible optical coherence tomography (OCT) changes. A 30-year-old hospital pathologist presented with a unilateral central scotoma after increased use of the light microscope. OCT of the macula at presentation and after 8 months demonstrated focal outer segment hyper-reflective spots at the centre of the fovea. There were no visible changes on fundoscopy and blue-light autofluorescence imaging. The symptoms resolved after advising the patient to limit the brightness and duration of light microscope use. The hazards of using the light microscope should be recognized, and light exposure and brightness minimized. OCT can help detect objective changes when the fundus looks normal on examination.