Unilateral acute idiopathic maculopathy secondary to yellow fever disease: a case report

Dompieri, Rodrigo Crispim; Manzano, Roberta Pereira de Almeida; Frazão, Maria Auxiliadora Monteiro; Kurimori, Helena Yuri; Chao, John Chii Tyng; Lui, Aline Cristina Fioravanti

doi:10.1016/j.ajoc.2019.100464

Cited by 11 publications

(16 citation statements)

References 6 publications

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“…In our case, the outer retinal and RPE anatomic changes with subretinal fluid and disrupted ellipsoid zone of the photoreceptors following the recovery of the anatomic changes and the visual acuity are consistent with AIM. 1 , 2 , 3 , 4 , 8 , 9 , 10 , 11 However, the thickening of the RPE and persistent RPE defect were more severe than that reported for AIMs. 1 , 2 , 3 , 4 , 8 , 9 , 10 , 11 With the Pfizer vaccines, 13 the mRNA for a spike protein is encapsulated in lipid nanoparticles which are endocytosed into muscle cells.…”

Section: Discussionmentioning

confidence: 68%

“… 1 , 2 , 3 , 4 , 8 , 9 , 10 , 11 However, the thickening of the RPE and persistent RPE defect were more severe than that reported for AIMs. 1 , 2 , 3 , 4 , 8 , 9 , 10 , 11 With the Pfizer vaccines, 13 the mRNA for a spike protein is encapsulated in lipid nanoparticles which are endocytosed into muscle cells. The mRNA is translated into a spike protein in the host cells.…”

Section: Discussionmentioning

confidence: 68%

“…The pathogenesis of AIM remains largely unresolved although the involvement of coxsackievirus, zika virus, and yellow fever virus has been hypothesized. 8 , 9 , 10 , 11 Recently, Venkatesh and associates reported a case of AIM following COVID-19 infection, that is the first report of AIM associated with COVID-19 infection. 12 Indeed, the association of AIM with virus and prodromal flu-like illness, suggests that this disease mechanism may result from a direct viral infection of the RPE cells or an immune-mediated damage of the RPE cells.…”

Section: Discussionmentioning

confidence: 99%

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Acute idiopathic maculopathy after COVID-19 vaccination

Hasegawa

Sannomiya

Toyoda

et al. 2022

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute idiopathic maculopathy after COVID-19 vaccination

Hasegawa

Sannomiya

Toyoda

et al. 2022

American Journal of Ophthalmology Case Reports

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“…In the literature, the state of health at the time of UAIM or just prior to the ophthalmic manifestation has been clearly documented in 46 cases, with the following findings: flulike illness (n = 13), 6 , 21 , 22 , 23 , 24 , 25 , 26 healthy (negative for recent medical history; n = 12), 6 , 9 , 12 , 14 , 19 , 27 , 28 , 29 , 30 , 31 , 32 HFMD (n = 7), 8 , 9 , 20 , 33 , 34 , 35 pregnancy (n = 3), 1 , 7 orchitis (n = 2), 9 anterior uveitis (n = 1), 12 acute tonsillitis (n = 1), 12 pharyngitis (n = 1), 18 laryngitis (n = 1), 15 gastroenteritis (n = 1), 13 and Hashimoto disease (n = 1). 12 Other specific viral infections have also been implicated, including HIV (n = 1), 7 yellow fever (n = 1), 36 and Zika virus (n = 1). 37 In 26 cases (57%) it seems that a viral infection was coincident with disease, which is not readily understandable, given the far more common unilateral presentation of UAIM when bilateral disease would be expected.…”

Section: Discussionmentioning

confidence: 99%

Incidental unilateral idiopathic maculopathy in children

Georgiou

McAnena

Michaelides

et al. 2020

Journal of American Association for Pediatric Ophthalmology and

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To investigate the clinical findings and differential diagnosis of incidental unilateral discoid maculopathy in a case series of children. METHODS The medical records and retinal imaging of children referred to a single center for flat, well circumscribed, hypopigmented discoid macular lesion in the left eye were reviewed retrospectively. RESULTS Three children (age range, 4-11 years; 2 female), with no subjective ophthalmic complaints, were referred for investigation of a flat, well-circumscribed, hypopigmented discoid macular lesion in the left eye. Case 1 had a history of viral mesenteric adenitis, and case 2 had a history of hand, foot, and mouth disease. For case 3, no previous history of systemic viral infection was established. Snellen visual acuity was 20/20 for all 3 children. The lesion was located superior to the fovea for case 1 and centered to the fovea for cases 2 and 3, all in the left eye. In all 3 patients, hyperautofluorescent changes were noted around the edges of the lesion, which was roughly discoid. OCT showed subtle changes of the interdigitation zone and retinal pigment epithelium (RPE) for cases 1 and 2. In case 3 the presence of hyperreflective, hypertrophic tissue at the level of the interdigitation zone and/or the RPE was noted. CONCLUSIONS In these 3 children with subclinical, unilateral discoid maculopathy sharing common features and identified incidentally, previous viral illness may have been causative. These cases may represent resolved unilateral acute idiopathic maculopathy. (J AAPOS 2020;-:1.e1-6) I n recent years, the number of incidental findings and referrals across all the disciplines of medicine, including ophthalmology, has increased because of screening programs and developments in medical imaging. 1,2 The epidemiological data for incidental findings are limited and difficult to collect, because they involve private practice and public hospitals, optometrist, ophthalmologists, and other disciplines, as well as screening programs and routine checkups. Incidental findings can be benign or malignant, inflammatory, infectious , inherited, or congenital-developmental. We present a case series of 3 children with a benign, unilateral discoid maculopathy, sharing common features, identified incidentally, and referred to a tertiary eye center for further investigation. Methods This study complies with all local laws and the principles of the Declaration of Helsinki and was approved by the Moorfields Eye Hospital Ethics Committee. The patients were examined by medical retina specialists, in Moorfields Eye Hospital, London. All available clinical notes and retinal imaging were reviewed. Further detailed medical history was requested from the caring general practitioners of the children. Results Three children (age range, 4-11 years; 2 female) were referred after presenting to their local optometrist for routine eye examination, with no subjective ophthalmic complaints, on discovery of an unusual left circular macular lesion (Figures 1-3). All 3 children denied any visual disturbanc...

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“…Less commonly HIV, flavivirus febricis infection, and H1N1 vaccination were reported to be associated as well. [3][4][5][6] The prognosis is generally good, with poor vision usually resulting from complications such as choroidal neovascularization or subfoveal pigment degeneration. 1,7 Here, we report multimodal imaging findings in a patient with acute idiopathic maculopathy.…”

mentioning

confidence: 99%

Case Report: Multimodal Imaging of Acute Idiopathic Maculopathy in a Chinese Woman

et al. 2021

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SIGNIFICANCE: Acute idiopathic maculopathy is a rare disease with the characteristics of sudden, severe, unilateral central vision loss after a flu-like illness. The prognosis is generally good, and poor vision usually results from complications such as choroidal neovascularization or subfoveal pigment degeneration. Multimodal imaging is helpful in the diagnosis and follow-up of this disease. PURPOSE:We report a case of acute idiopathic maculopathy and present multimodal imaging results in the diagnosis of this condition.CASE REPORT: A 37-year-old Chinese woman noted a central scotoma in her right eye a day after a prodrome of flu-like symptoms. Best-corrected visual acuity of the right eye was 20/40. Multimodal imaging was performed, and a diagnosis of acute idiopathic maculopathy was made. The variable clinical appearance of acute idiopathic maculopathy on autofluorescence, near-infrared reflectance, and optical coherence tomography (OCT) was shown. The patient's vision spontaneously recovered to 20/20 two weeks after the onset of the disease, but macular sensitivity, as measured by microperimetry, did not return to normal until 1 month. Retrobulbar injection of triamcinolone was done at 3 weeks to prevent retinal pigment epithelium hyperplasia and choroidal neovascularization. Written informed consent was obtained from the patient. CONCLUSIONS: Our findings suggest that near-infrared reflectance corresponds to the change of the outer retina and retinal pigment epithelium on OCT and complements autofluorescence in the diagnosis and follow-up of acute idiopathic maculopathy. Fundus autofluorescence, near-infrared reflectance, and OCT are recommended as routine examinations in this disease.

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Unilateral acute idiopathic maculopathy secondary to yellow fever disease: a case report

Cited by 11 publications

References 6 publications

Acute idiopathic maculopathy after COVID-19 vaccination

Acute idiopathic maculopathy after COVID-19 vaccination

Incidental unilateral idiopathic maculopathy in children

Case Report: Multimodal Imaging of Acute Idiopathic Maculopathy in a Chinese Woman

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