Uniform soluble support for the large-scale synthesis of sequence-defined macromolecules

Abstract

Herein, a monodisperse soluble support is explored and used as an effective tool for the large-scale, liquid-phase synthesis of sequence-defined macromolecules. This support, based on a benzyl derivative with three...

Telechelic sequence-defined oligoamides: their step-economical synthesis, depolymerization and use in polymer networks

“…24 This strategy has recently been adapted by our research group to scale-up the synthesis of oligo(ester urethane)s via a thiolactone chemistry-based iterative protocol, while facilitating the purication and monitoring of the intermediate reaction steps. 25 A variety of chemical backbones that could be synthesized via iterative protocols have been explored in the last years. 26 Among them, sequence-dened oligomers containing amide bonds are gaining major interest in many areas of research.…”

Sequence-defined antibody-recruiting macromolecules

“…[8][9][10][11][12] Multiple strategies have been developed in the last decade to achieve the synthesis of sequence dened macromolecules (SDMs). 8,[13][14][15] Thiolactone chemistry, for example, has been explored by our group and others [16][17][18] for the synthesis of a wide range of discrete macromolecules including stereocontrolled oligomers, polyampholytes, 11 and star-shaped macromolecules. 19 This chemistry proved very efficient in advanced applications such as single-chain nanoparticles 12 or data storage [20][21][22] and it has been selected in this research for the design of antibody recruiting polymers.…”

Solid-phase synthesis of iterative RAFT single unit monomer insertion adducts

“…8,9 There have even been developments in using the benefits of both solution and solid phase synthesis through precipitating anchors. 10 These methodologies generally produce molecules with heteroatom-containing backbones that often made through processes analogous to step-growth polymerisation (Scheme 1a).…”