Uniform Rattle‐type Hollow Magnetic Mesoporous Spheres as Drug Delivery Carriers and their Sustained‐Release Property

Abstract

A novel kind of rattle‐type hollow magnetic mesoporous sphere (HMMS) with Fe3O4 particles encapsulated in the cores of mesoporous silica microspheres has been successfully fabricated by sol–gel reactions on hematite particles followed by cavity generation with hydrothermal treatment and H2 reduction. Such a structure has the merits of both enhanced drug‐loading capacity and a significant magnetization strength. The prepared HMMSs realize a relatively high storage capacity up to 302 mg g−1 when ibuprofen is used as a model drug, and the IBU–HMMS system has a sustained‐release property, which follows a Fick's law.

Application of Acoustic Bessel Beams for Handling of Hollow Porous Spheres

“…In micro and nano scales, porous shells have found numerous applications in modern medicine, pharmacology, biotechnology and chemistry. Porous shells are now widely used as drug delivery carriers (Slowing et al 2008;Cheng et al 2009;Andersson et al 2004;Lai et al 2003;Radu et al 2004;Mal et al 2003;Zhao et al 2008), magnetic resonance imaging (MRI) contrast agents (Gao et al 2008;Campbell et al 2011;Davis 2002), etc. In the context of drug delivery carriers, the inner cavity of such particles can store large amounts of drugs, and the encapsulating porous shells provides delivery pathway for drug molecules diffusion.…”

Synthesis, characterization and magnetic properties of hematite (α-Fe2O3) nanoparticles on polysaccharide templates and their antibacterial activity

“…solution (Laurent et al 2008) . Ferromagnetic particles can also be synthesized through the hematite route owing to the higher stability of hematite and then subsequently reduced to magnetite (Zhao et al 2008). Recently, the use of iron oxide nanoparticles in photonic applications has also been reported (Ge et al 2008).…”

Mesoporous silica hollow capsules embedded with magnetic nanoparticles

“…However, our preparation method of the mMSHCs provided the Ms value comparable to the reported magnetic capsules [8][9][10][11][12][13][14][15][16][17][18]. As shown in Figure 6(b), the Ms value of our mMSHCs was large enough to show a magnetic separation using a neodymium magnet.…”

“…Specifically, the magnetic properties allow the magnetically-guided drug delivery for the therapy and the contrast-enhanced magnetic resonance imaging for the diagnosis. So far, various types of mMSHCs have been reported; the mMSHC incorporating the mNPs on the outer surface of the shell [7], inside the shell [8,9], or in the hollow cavity [10][11][12] and the rattle-type mMSHC that encapsulates one magnetic particle in its hollow cavity [13][14][15][16][17][18].…”