Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer Cells

Abstract

Uniform polypyrrole (PPy) nanoparticles are fabricated from a facile one-step aqueous dispersion polymerization. Owing to their high photothermal conversion efficiency and photostability compared with the well-known Au nanorods, as well as their good colloidal stability and biocompatibility, the resulting PPy nanoparticles can used as a novel promising photothermal ablation coupling agent for targeted treatment of cancer.

Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation

“…Light has a higher penetration depth in the NIR optical window between 700 and 900 nm, where human tissue has minimal absorption, scattering, and fluorescence. 8 A vast majority of the research in this field has focused on the use of gold nanoparticles (GNPs), including gold nanorods (GNRs) 9 and gold nanoshells (GNSs), 10,11 as well as the use of carbon-based materials, including conductive polymers, [12][13][14][15] graphene oxide, 16 and single-and multiwalled carbon nanotubes 17,18 as PTT agents. While the potential of GNPs has been demonstrated in several instances and their development has reached the level of phase 1 clinical trials, the effectiveness and safety of carbon-based PTT agents have not been fully investigated.…”

光热响应的Cu7S4@pNIPAm纳米载体应用于可控的药物/光热治疗

“…Gold nanomaterials such as nanorods [24], nanoshells [25], nanostars [26] and nanocages [27,28] are one of the mostly investigated agents due to their easy accessibility. Yet, recent results indicated that these kinds of photothermal agents suffer from poor photostability under continuous irradiation of NIR light [29,30]. Such issue has driven researchers to explore novel types of photothermal agents.…”

Evaluation of a Smart Polymer Nanosphere for Potential Use in Anticancer Drug Delivery

“…This could induce a controlled and sustained release in the appropriate environment. The triggered release of a drug in an appropriate location upon external stimuli such as changes of pH or redox environment would qualify the ppy-chit nanospheres as smart materials 11 .…”