光热响应的Cu7S4@pNIPAm纳米载体应用于可控的药物/光热治疗

Abstract

Drug delivery systems (DDSs) have been getting more and more attention in the field of cancer therapy with the development of nanotechnology. But remote and noninvasive controlled drug release for improving treatment efficacy and reducing side effects faces great challenge. We report a kind of "smart" nanocomposites (NCs) that is sensitive to the surrounding temperature by grafting a layer of thermosensitive polymer, poly(N-isopropylacrylamide) (pNIPAm), on the surface of single Cu7S4 nanoparticle (NP) via atomtransfer radical polymerization (ATRP). These NCs demonstrate a photothermal conversion efficiency of 25.4% under 808-nm near infrared (NIR) light irradiation and a drug loading content of 19.4% (drug/total NCs, w/w) with a lower critical solution temperature (LCST) of~38°C. At normal physiological temperature (37°C), only 10.8% of the loaded doxorubicin (DOX) was released at physiological pH value (pH 7.4) within 10 h. In the presence of 808-nm irradiation, due to the temperature increment as a result of photothermal effects, DOX was rapidly released.

Multifunctional Cu1.94S-Bi2S3@polymer nanocomposites for computed tomography imaging guided photothermal ablation

“…As for the choice of the irradiation light wavelength, although the absorption of the Cu 1.94 S NPs at 980 nm or 1500 nm was stronger than that at 808 nm (Fig. S6), yet under 980-nm or 1500-nm laser irradiation, the temperature increase of pure water was much higher than that under 808-nm laser [56]. In view of biomedical applications, inducing minimal harm to normal tissue is the prerequisite.…”

Organic/polymer photothermal nanoagents for photoacoustic imaging and photothermal therapy in vivo

“…By collecting these photothermally generated ultrasound signals through a broadband ultrasonic transducer and transforming them into images, PA imaging integrates the merits of high contrast of optical imaging with high spatial resolution of ultrasound imaging, realizing disease diagnosis in deeper tissue with high contrast and resolution [11][12][13]. Owing to their excellent heat generation ability, photothermal agents are also widely used in PTT [4,[14][15][16][17]. Attractively, the two functions of photothermal agents, PA imaging and PTT, are complementary [18].…”

Humidity-responsive nanocomposite of gold nanoparticles and polyacrylamide brushes grafted on Ag film: synthesis and application as plasmonic nanosensor

“…Recently, several strategies to stabilize metallic NPs on metal surfaces have been reported [18,19]. Furthermore, brushes of stimuli-responsive polymer, with unique structure and high diversity in functionalities, have been applied for the assembly of metal NPs on macroscopic surfaces with efficient control [20,21]. Sophisticated systems made of stimuli-responsive brushes assembled with gold or silver-NPs were proposed for SERS applications, with vast plasmonic hotspots formed under external stimulus [22][23][24][25][26].…”