Uniform Fe₃O₄/Gd₂O₃-DHCA nanocubes for dual-mode MR imaging

Abstract

Multimodal imaging technology were extensively studied over past few years, because they offered complementary diagnosis information, which can increase the accuracy of diagnosis. The synthesis of contrast agents via simplified methods are desired for the development of multimodal imaging. Herein, uniformly distributed Fe3O4/Gd2O3 nanocubes for T1-T2 dual-mode contrast agents were rationally designed and successfully fabricated by our group. In this system, the Fe3O4/Gd2O3 nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA) for better hydrophilia and biocompatibility. The results show that Ferrum (Fe) and Gadolinium (Gd) elements are homo-dispersity in the Fe3O4/Gd2O3-DHCA (FGDA) nanocubes. Relaxivity study at 3.0 T scanner demonstrates that the r1 value and r2 value of FGDA nanocubes reach up to 67.57 ± 6.2 mM-1s-1 and 24.2 ± 1.46 mM-1s-1. The images of T1-weighted and T2-weighted imaging in vivo demonstrate that FGDA nanocubes possess the ability of magnetic resonance (MR) imaging enhancement as dual-mode contrast agent. The above illustrated experimental results indicate that FGDA nanocubes can be applied in clinical diagnosis in future.

Nanodiagnosis and Nanotreatment of Cardiovascular Diseases: An Overview

“…Twin-modal frameworks have been suggested in order to acquire the effects of both T1 and T2 contrast agents. In this context, Qin et al [112] stated that uniformly distributed Fe 3 O 4 /Gd 2 O 3 core@shell NPs were rationally designed and produced successfully for T1-T2 dual-mode contrast agents. For improved hydrophilia and bioactivity, the Fe 3 O 4 /Gd 2 O 3 core@shell NPs have been coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA).…”

Fe2O3 Nanoparticles Doped with Gd: Phase Transformations as a Result of Thermal Annealing

“…In addition, most of the synthesis methods imply a complex chain of sequential modifications and operations, which entails high energy and resource consumption. However, despite the large number of works in this area [8,[15][16][17][18][19][20][21], studies related to the search for optimal conditions for obtaining nanoparticles and the effect of their structural and phase modifications on biocompatibility and toxicity are still relevant and have great prospects for study.…”