Abstract:The multimodal magnetic resonance imaging (MRI) technique has been extensively studied over the past few years since it offers complementary information that can increase diagnostic accuracy. Simple methods to synthesize contrast agents are necessary for the development of multimodal MRI. Herein, uniformly distributed Fe3O4/Gd2O3 nanocubes for T1–T Show more
“…For efficiently improving the hydrophilicity and biocompatibility of nanocubes, Qin et al further designed Fe 3 O 4 /Gd 2 O 3 nanocubes by coating the surface with non-toxic 3,4-dihydroxycinnamic acid. 69 Based on the analysis of the images obtained from a 3.0 T scanner, the values of r 1 and r 2 are 67.57 ± 6.2 and 24.2 ± 1.46 mM −1 s −1 respectively. Therefore, the Fe 3 O 4 /Gd 2 O 3 -DHAC nanocubes with good biocompatibility can be used as T 1 – T 2 dual-mode magnetic resonance contrast agents to better demonstrate the ability to diagnose and treat tumors.…”
Section: Engineered Nanomaterials With Various Shapes For Dual-mode M...mentioning
confidence: 98%
“…In addition, 3,4-dihydroxycinnamic acid increased the dispersibility of the nanocubes, thus ensuring the stability of the nanocubes in the body. 69 In addition to enhancing the dispersion and biocompatibility of nanoprobes, surface modification also helps to improve targeting. Gao et al prepared tumor-penetrating peptide RGE modified Fe 3 O 4 @SiO 2 @mSiO 2 /DOX-(Gd-DTPA) core-shell nanoparticles.…”
Section: The Synthesis Of T 1 -T 2 Dual-mode Mri Nanoprobesmentioning
confidence: 99%
“…Li et al developed Fe 3 O 4 /Gd 2 O 3 nanocubes used as T 1 -T 2 dual-mode MRI contrast agents by a simple one-pot thermal decomposition method. 108 69 Based on the analysis of the images obtained from a 3.0 T scanner, the values of r 1 and r 2 are 67.57 ± 6.2 and 24.2 ± 1.46 mM −1 s −1 respectively. Therefore, the Fe 3 O 4 /Gd 2 O 3 -DHAC nanocubes with good biocompatibility can be used as T 1 -T 2 dual-mode magnetic resonance contrast agents to better demonstrate the ability to diagnose and treat tumors.…”
Shape effect is an important parameter in the design of novel nanomaterials. Engineering the shape of nanomaterials is an effective strategy for optimizing their bioactive performance. Nanomaterials with unique shape...
“…For efficiently improving the hydrophilicity and biocompatibility of nanocubes, Qin et al further designed Fe 3 O 4 /Gd 2 O 3 nanocubes by coating the surface with non-toxic 3,4-dihydroxycinnamic acid. 69 Based on the analysis of the images obtained from a 3.0 T scanner, the values of r 1 and r 2 are 67.57 ± 6.2 and 24.2 ± 1.46 mM −1 s −1 respectively. Therefore, the Fe 3 O 4 /Gd 2 O 3 -DHAC nanocubes with good biocompatibility can be used as T 1 – T 2 dual-mode magnetic resonance contrast agents to better demonstrate the ability to diagnose and treat tumors.…”
Section: Engineered Nanomaterials With Various Shapes For Dual-mode M...mentioning
confidence: 98%
“…In addition, 3,4-dihydroxycinnamic acid increased the dispersibility of the nanocubes, thus ensuring the stability of the nanocubes in the body. 69 In addition to enhancing the dispersion and biocompatibility of nanoprobes, surface modification also helps to improve targeting. Gao et al prepared tumor-penetrating peptide RGE modified Fe 3 O 4 @SiO 2 @mSiO 2 /DOX-(Gd-DTPA) core-shell nanoparticles.…”
Section: The Synthesis Of T 1 -T 2 Dual-mode Mri Nanoprobesmentioning
confidence: 99%
“…Li et al developed Fe 3 O 4 /Gd 2 O 3 nanocubes used as T 1 -T 2 dual-mode MRI contrast agents by a simple one-pot thermal decomposition method. 108 69 Based on the analysis of the images obtained from a 3.0 T scanner, the values of r 1 and r 2 are 67.57 ± 6.2 and 24.2 ± 1.46 mM −1 s −1 respectively. Therefore, the Fe 3 O 4 /Gd 2 O 3 -DHAC nanocubes with good biocompatibility can be used as T 1 -T 2 dual-mode magnetic resonance contrast agents to better demonstrate the ability to diagnose and treat tumors.…”
Shape effect is an important parameter in the design of novel nanomaterials. Engineering the shape of nanomaterials is an effective strategy for optimizing their bioactive performance. Nanomaterials with unique shape...
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