The pipe hanger is an important part of steam pipeline system in power plant. In order to study the influence of pipe hangers on creep damage of main-steam pipe containing defects. In the paper, the main-steam pipe with defects was taken as the research objects. The pipe analysis model with pipe hanger was established. Based on the creep damage mechanics, the influence of distance and arrangement of pipe hanger constraints was studied, and the effects of creep stress at pipe defects were given. The results show that the pipe hanger can greatly influence the creep stress distribution of pipe. With the decreasing of pipe hanger distance between the defect, the stress intensity increased. The creep stress of defect were also researched under different type of pipe hanger, and the fixed constraint hanger has the maximum stress. The results can give the constructive suggestion for the engineering design of the arrangement of pipe hanger.