Ungual hyalohyphomycosis caused by Fusarium proliferatum in an immunocompetent patient

Abstract

The patient was a 73-year-old healthy female farmer who had been treated with terbinafine for 25.5 months by a primary physician. She exhibited a discoloration and thickening of the right big toenail. She had no concomitant paronychia. Direct microscopy revealed chlamydoconidia and hyphae, and periodic acid-Schiff stained nail specimen showed septate hyphae. On the basis of these morphological features and gene analysis, the final diagnosis was ungual hyalohyphomycosis caused by Fusarium proliferatum. Topical application of 10% efinaconazole solution cured the disease in 10 months.

A Case of Laying Hens Mycosis Caused by Fusarium proliferatum

“…By analogy with paper, we carried out a study using direct microscopy, further cultured and identified the isolate morphologically and by PCR as for F. proliferatum . Direct microscopy revealed chlamydioconidia and hyphae in the same way as in the paper [ 36 ]. The isolate had typical morphological properties.…”

Ungual hyalohyphomycosis caused by Fusarium cugenangense

“…An amphotericin B solution (2.0 mg/mL in a 1:1 mixture of DSMO and isopropyl alcohol) was applied in Switzerland 11 . In Japan, five patients were successfully treated with antifungals (itraconazole, n = 2; efinaconazole, n = 2; voriconazole, n = 1), and the proportion of patients cured with antifungals was 29.4% (5/17 cases) 12 . The MIC of efinaconazole against Fusarium species is lower than that of itraconazole 10,13 .…”

“…11 In Japan, five patients were successfully treated with antifungals (itraconazole, n = 2; efinaconazole, n = 2; voriconazole, n = 1), and the proportion of patients cured with antifungals was 29.4% (5/17 cases). 12 The MIC of efinaconazole against Fusarium species is lower than that of itraconazole. 10,13 Moreover, efinaconazole shows a broad spectrum of antifungal activities and is expected to be effective for nondermatophyte onychomycosis due to Candida, Aspergillus, and Fusarium species.…”

Interdigital Hyalohyphomycosis Caused by Members of the Fusarium solani Species Complex

“…Fusarium petroliphilum and F. keratoplasticum are found in environments and cause invasive pulmonary infection or sinusitis in immunocompromised patients, which may disseminate to other organs and causes sepsis (7,8). FSSC members degrade keratin, with lower ability than dermato phytes (9), and cause superficial cutaneous inflammation (10).…”