Ungual hyalohyphomycosis caused by <i>Fusarium cugenangense</i>

Hirose, Mina; Noguchi, Hiromitsu; Matsumoto, Tadahiko; Kimura, Utako; Hiruma, Masataro; Kano, Rui; Yaguchi, Takashi; Fujimoto, Norihiro; Satoh, Takahiro; Ihn, Hironobu

doi:10.1002/ccr3.2941

Cited by 4 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 In addition, nine cases were treated with TBF or ITCZ pulse therapy; however, both drugs were only partially effective on Fusarium onychomycosis. 29 As shown in our case, physical removal or fenestration of the affected nail, 8,20,27,36,37 or topical application of antifungal agents, 8,10,12,20,21,23,24,27,38…”

Section: Clinical Type Of Onychomycosis and Fusarium Sppsupporting

confidence: 62%

“…Among the patients, one digit (finger or toe, 27 of 39 cases, 70%) was the most commonly affected site (Tables 2–5). Immunocompromised conditions among the patients included acute myeloid leukemia 6 aplastic anemia, 7 diabetes, 8,9 Behcet disease, 10 squamous cell carcinoma, 11 and immunodeficiency 12 . The periungual regions of the toes can be portals of entry for Fusarium spp 13…”

Section: Literature Reviewmentioning

confidence: 99%

“…Moreover, gene analysis has been performed mainly in Asian countries with 16 cases reported by molecular identification, suggesting that methods used to detect Fusarium spp. differ among countries 2,8–10,12,14,19–25 . Landreau et al reported in a recent survey of superficial fungal infections in France that one of the reasons for the increased proportion of Fusarium spp.…”

Section: Literature Reviewmentioning

confidence: 99%

“…To assess relationships among paronychia and Fusarium spp., we reviewed 19 paronychia patients of 57 cases (33%) 8,10,20,21,27–29 and revealed 10 of 21 FOSC cases (48%) 8,27–29 manifested paronychia. In contrast, only four of 23 cases of onychomycosis by FSSC (17%) were associated with paronychia, suggesting that F. solani –associated onychomycosis involves less inflammation than conditions caused by other Fusarium spp 10,25,30 .…”

Section: Literature Reviewmentioning

confidence: 99%

“…29 and revealed 10 of 21 FOSC cases (48%)8,[27][28][29] manifested paronychia. In contrast, only four of 23 cases of onychomycosis by FSSC (17%) were associated with paronychia, suggesting that F. solani-associated F I G U R E 2 Mycological findings.…”

mentioning

confidence: 98%

See 4 more Smart Citations

Possibly the first case of onychomycosis by Fusarium lactis: Case presentation and literature review of onychomycosis by Fusarium species

Taga,

Anzawa,

Ono

et al. 2023

The Journal of Dermatology

View full text Add to dashboard Cite

Fusarium species (spp.) is frequently found in soil and plant residues and on plant bodies in all climatic zones worldwide. Although there have been few reports of onychomycosis caused by Fusarium spp., it is characterized by drug sensitivity and other characteristics. Here, we report what may be the first case of onychomycosis caused by Fusarium lactis. We analyzed the mycology and characterized previously reported cases of onychomycosis caused by Fusarium spp. A 73‐year‐old otherwise healthy woman presented with discoloration and thickening of her right thumbnail with paronychia. Direct microscopy revealed unevenly swollen hyphae, and a Grocott‐stained nail specimen showed septate hyphae. Based on the morphological features and gene analysis of fungus isolated from the nail, we diagnosed onychomycosis caused by F. lactis belonging to Fusarium fujikuroi species complex. Partial nail removal and topical application of 1% luliconazole solution resolved the condition in 6 months. Minimum inhibitory concentrations for isolated F. lactis showed high sensitivity to luliconazole but not itraconazole or terbinafine. The isolated F. lactis was temperature‐sensitive. A search of the literature revealed 57 cases of onychomycosis caused by Fusarium spp. with delineated clinical characteristics. Since those cases were investigated using morphological and/or molecular methods, we analyzed them by species complex as well as species. Onychomycosis caused by Fusarium spp. is predominantly found on the big toe, with Fusarium solani species complex and Fusarium oxysporum species complex accounting for over 70% of cases. Infection of only one digit with paronychia is a characteristic clinical manifestation of onychomycosis caused by Fusarium spp. Since there has been an increase in instances of molecular determination of Fusarium spp., it is deemed necessary to clarify its clinical and fungal nature. Due to its characteristic drug sensitivity and temperature‐sensitive nature, new treatments are expected to be developed.

show abstract

Section: Clinical Type Of Onychomycosis and Fusarium Sppsupporting

confidence: 62%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

mentioning

confidence: 98%

See 3 more Smart Citations

Possibly the first case of onychomycosis by Fusarium lactis: Case presentation and literature review of onychomycosis by Fusarium species

Taga,

Anzawa,

Ono

et al. 2023

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

A comprehensive review of nondermatophyte mould onychomycosis: Epidemiology, diagnosis and management

Gupta,

Wang,

Cooper

et al. 2023

Acad Dermatol Venereol

View full text Add to dashboard Cite

Nondermatophyte moulds (NDMs) are widely distributed and can be detected in association with mycotic nails; however, sometimes it can be challenging to establish the role of NDMs in the pathogenesis of onychomycosis (i.e. causative vs. contaminant). In studies where the ongoing invasive presence of NDMs is confirmed through repeat cultures, the global prevalence of NDMs in onychomycosis patients is estimated at 6.9% with the 3 most common genus being: Aspergillus, Scopulariopsis and Fusarium. NDM onychomycosis can, in many cases, appear clinically indistinguishable from dermatophyte onychomycosis. Clinical features suggestive of NDMs include proximal subungual onychomycosis with paronychia associated with Aspergillus spp., Fusarium spp. and Scopulariopsis brevicaulis, as well as superficial white onychomycosis in a deep and diffused pattern associated with Aspergillus and Fusarium. Longitudinal streaks seen in patients with distal and lateral onychomycosis may serve as an additional indicator. For diagnosis, light microscopic examination should demonstrate fungal filaments consistent with an NDM with at least two independent isolations in the absence of a dermatophyte; the advent of molecular testing combined with histological assessment may serve as an alternative with improved sensitivity and turnover time. In most instances, antifungal susceptibility testing has limited value. Information on effective treatments for NDM onychomycosis is relatively scarce, unlike the situation in the study of dermatophyte onychomycosis. Terbinafine and itraconazole therapy (continuous and pulsed) appear effective to varying extents for treating onychomycosis caused by Aspergillus, Fusarium or Scopulariopsis. There is scant literature on oral treatments for Neoscytalidium.

show abstract

Onychomycosis due to Fusarium species in different continents, literature review on diagnosis and treatment

Haghani,

Hedayati,

Shokohi

et al. 2023

Mycoses

View full text Add to dashboard Cite

Fusarium species are an emerging cause of onychomycosis, and the number of cases has dramatically increased in recent decades worldwide. This review presents an overview of the onychomycosis cases caused by Fusarium species and diagnosis and treatment that have been reported in the literature. The most common causative agent of onychomycosis is F. solani species complex, which accounts for 11.68% of the cases of Fusarium onychomycosis, followed by the F. oxysporum species complex (164 out of 1669), which is accounted for 9.83% of the total. F. fujikuroi species complex (42 out of 1669) and F. dimerum species complex (7 out of 1669) are responsible for 2.52% and 0.42 cases, respectively. Fusarium nail infections were reported in patients aged range 1–98, accounting for 5.55% (1669 out of 30082) of all cases. Asia has the highest species diversity of Fusarium onychomycosis (31.51%). South America accounts for 21.09%, and the most common causative agent is F. solani (19.32%), followed by F. oxysporum species complex (15.63%). Europe accounts for 4.90% of cases caused by F. oxysporum, followed by F. solani. Africa accounts for 23.87% of the cases due to the F. solani species complex, followed by F. oxysporum and F. fujikuroi. Distal and lateral subungual onychomycosis was the most common clinical symptom accounting for 58.7% (135 out of 230) of the cases. Data analysis relieved that terbinafine and itraconazole are active treatments for Fusarium onychomycosis. For a definitive diagnosis, combining of direct examination, culture and sequencing of the elongation factor of translation 1α are recommended. Accurate identification of the causative agents of onychomycosis due to Fusarium species and antifungal susceptibility testing is essential in patient management.

show abstract

Ungual hyalohyphomycosis caused by Fusarium cugenangense

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 14 publications

Possibly the first case of onychomycosis by Fusarium lactis: Case presentation and literature review of onychomycosis by Fusarium species

Possibly the first case of onychomycosis by Fusarium lactis: Case presentation and literature review of onychomycosis by Fusarium species

A comprehensive review of nondermatophyte mould onychomycosis: Epidemiology, diagnosis and management

Onychomycosis due to Fusarium species in different continents, literature review on diagnosis and treatment

Contact Info

Product

Resources

About