Unfolding the electrospinning potential of biopolymers for preparation of nanofibers

Jain, Ritu; Shetty, Saritha; Yadav, Khushwant S.

doi:10.1016/j.jddst.2020.101604

Cited by 97 publications

(66 citation statements)

References 103 publications

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“…In this manner, fibers mimic the extracellular matrix; and their use as antibacterial, wound dressing, suture, and scaffold materials has been widely proposed [ 31 , 32 ]. The most common way to produce fibers of different materials is by employing the electrospinning technique and its variants [ 33 ].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Microbial Exopolysaccharides as Drug Carriers

Cardea

2020

Polymers

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Microbial exopolysaccharides are peculiar polymers that are produced by living organisms and protect them against environmental factors. These polymers are industrially recovered from the medium culture after performing a fermentative process. These materials are biocompatible and biodegradable, possessing specific and beneficial properties for biomedical drug delivery systems. They can have antitumor activity, they can produce hydrogels with different characteristics due to their molecular structure and functional groups, and they can even produce nanoparticles via a self-assembly phenomenon. This review studies the potential use of exopolysaccharides as carriers for drug delivery systems, covering their versatility and their vast possibilities to produce particles, fibers, scaffolds, hydrogels, and aerogels with different strategies and methodologies. Moreover, the main properties of exopolysaccharides are explained, providing information to achieve an adequate carrier selection depending on the final application.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Microbial Exopolysaccharides as Drug Carriers

Cardea

2020

Polymers

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“…Nanofibers are fibrous structures with diameters less than 100 nm. These nanostructures possess a high surface area to volume ratio, high porosity, and small pore size, enabling favorable conditions for liquid adsorption in filter media, limiting bacterial penetration, and promoting wound healing [ 16 ]. Thus, it is not surprising that nanofibers have been studied as drug delivery systems in cancer treatment, surgical intervention, and tissue scaffolding [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

et al. 2021

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This study presents the development and characterisation of two novel bioactive coatings deposited on TiAlV and AISI 316LVM substrates. The coatings were prepared using 3D printing and electrospinning. The 3D-printed coating consisted of the cellulose nanofibril suspension, alginate, and carboxymethylcellulose (CMC), while CMC and polyethylene oxide were used to prepare the electrospun coating. Both coatings were loaded with the antibiotic clindamycin (CLIN), which is a bacteriostatic lincosamide known for its activity against streptococci, staphylococci, pneumococci, Bacteroides species, and other anaerobes. Initial characterisation of the coatings was performed by attenuated total reflectance Fourier transform infrared spectroscopy, field emission scanning electron microscopy, and atomic force microscopy. Furthermore, the contact angle measurements, swelling rate, and biodegradability of the coatings were investigated. The released concentration of CLIN in PBS (pH = 7.4 at 25 °C) was determined by UV-VIS spectrophotometry. The coatings’ biocompatibility was determined using an MTT (3(4,5 dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) assay using an osteoblast cell culture (hFOB 1.19, ATCC CRL 11372).

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“…The filter was made adopting the polyethylene terephthalate (PET) for the outer layer deposition and the polivinilidenfluoruro (PVDF) for the nanomembrane inner layer, developed via electrospinning [ 30 ] (dimensions 1460 × 2031 × 1435 mm). This latter technology offers a higher resolution and great advantages in material processing over a wide range of applications, such as biosensors [ 31 ], tissue engineering [ 32 , 33 ], drug delivery [ 34 ], and supercapacitors [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Masks for Powders and Viruses Safety Protection Using Food Grade Polymers: Empirical Tests

Foresti

Ghezzi

Vettori³

et al. 2021

Polymers

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The production of 3D printed safety protection devices (SPD) requires particular attention to the material selection and to the evaluation of mechanical resistance, biological safety and surface roughness related to the accumulation of bacteria and viruses. We explored the possibility to adopt additive manufacturing technologies for the production of respirator masks, responding to the sudden demand of SPDs caused by the emergency scenario of the pandemic spread of SARS-COV-2. In this study, we developed different prototypes of masks, exclusively applying basic additive manufacturing technologies like fused deposition modeling (FDM) and droplet-based precision extrusion deposition (db-PED) to common food packaging materials. We analyzed the resulting mechanical characteristics, biological safety (cell adhesion and viability), surface roughness and resistance to dissolution, before and after the cleaning and disinfection phases. We showed that masks 3D printed with home-grade printing equipment have similar performances compared to the industrial-grade ones, and furthermore we obtained a perfect face fit by customizing their shape. Finally, we developed novel approaches to the additive manufacturing post-processing phases essential to assure human safety in the production of 3D printed custom medical devices.

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Unfolding the electrospinning potential of biopolymers for preparation of nanofibers

Cited by 97 publications

References 103 publications

Microbial Exopolysaccharides as Drug Carriers

Microbial Exopolysaccharides as Drug Carriers

Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections

3D Printed Masks for Powders and Viruses Safety Protection Using Food Grade Polymers: Empirical Tests

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