Unfolding Remedial Targets for Alzheimer's Disease

Tamilselvan, M.; Tamilanban, T.; Chitra, V.

doi:10.5958/0974-360x.2020.00534.x

Cited by 3 publications

(1 citation statement)

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“…Specifically, cholinergic loss in the forebrain and cortex has been well documented in AD and linked to disruptions in episodic memory and executive function early within the progression of the disease [7]. While cholinesterase inhibitors may provide symptom relief by decreasing the degradation of acetylcholine, they do not address the underlying cause in the loss of cholinergic function [2,8]. Therefore, other treatment strategies that can maintain cholinergic neural health over simply increasing the circulation of acetylcholine may prove to be more fruitful.…”

Section: Introductionmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer’s Disease

McNerney

Heath

Narayanan

et al. 2022

JAD

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Background: Alzheimer’s disease (AD) is a debilitating disorder involving the loss of plasticity and cholinergic neurons in the cortex. Pharmaceutical treatments are limited in their efficacy, but brain stimulation is emerging as a treatment for diseases of cognition. More research is needed to determine the biochemical mechanisms and treatment efficacy of this technique. Objective: We aimed to determine if forebrain repetitive transcranial magnetic stimulation can improve cortical BDNF gene expression and cholinergic signaling in the 3xTgAD mouse model of AD. Methods: Both B6 wild type mice and 3xTgAD mice aged 12 months were given daily treatment sessions for 14 days or twice weekly for 6 weeks. Following treatment, brain tissue was extracted for immunological stains for plaque load, as well as biochemical analysis for BDNF gene expression and cholinergic signaling via acetylcholinesterase and choline acetyltransferase ELISA assays. Results: For the 3xTgAD mice, both 14 days and 6 weeks treatment regimens resulted in an increase in BDNF gene expression relative to sham treatment, with a larger increase in the 6-week group. Acetylcholinesterase activity also increased for both treatments in 3xTgAD mice. The B6 mice only had an increase in BDNF gene expression for the 6-week group. Conclusion: Brain stimulation is a possible non-invasive and nonpharmaceutical treatment option for AD as it improves both plasticity markers and cholinergic signaling in an AD mouse model.

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Section: Introductionmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer’s Disease

McNerney

Heath

Narayanan

et al. 2022

JAD

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Role of pyridines as enzyme inhibitors in medicinal chemistry

Khan

Gillani

Saleem

2023

Recent Developments in the Synthesis and Applications of Pyridines

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Pharmacological importance of Bacopa monnieri on Neurological disease (Alzheimer’s Disease) and Diabetic neuropathy - A Concise Review

Karati

Shaw²

2022

RJPT

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Disorders of the central nervous system are expected to have a profound impact on the global healthcare needs of the human community in this era. Alzheimer disease (AD) is senile decay of neurons. The hallmark of pathophysiology of AD disease has two pivotal features example- extracellular beta amyloid deposition and intracellular tau hyper phosphorylation. New medicine-based psychoactive treatments have met with modest effectiveness due to the multi-factorial nature of these diseases. As a result, there is an increasing need for new products that can address various receptors and enhance behavioural abilities on their own or in tandem with traditional medications. Herbal products focused on conventional expertise have been widely popular in both developed and developing countries in recent years. Ayurveda is a medical science that deals with the treatment of diseases using naturally occurring plant products. Ayurveda claims to have many neuroprotective herbs. In this review the pharmacological effectiveness and therapeutic properties of Bacopa monnieri (BM) against AD and diabetic peripheral neuropathy (DPN) have been discussed. DPN is also an utmost common neuronal disease. DPN affects more than half of diabetic patients who have had diabetes for more than 25 years. It is proved that a bacosides-rich fraction of BM has antinociceptive actions in rats, alleviating allodynia and hyperalgesia in a chronic constriction wound model of neuropathic discomfort. BM may be an important natural cure for the treatment of neuropathic pain syndromes.

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Unfolding Remedial Targets for Alzheimer's Disease

Cited by 3 publications

References 0 publications

Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer’s Disease

Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer’s Disease

Role of pyridines as enzyme inhibitors in medicinal chemistry

Pharmacological importance of Bacopa monnieri on Neurological disease (Alzheimer’s Disease) and Diabetic neuropathy - A Concise Review

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