Pharmacological importance of Bacopa monnieri on Neurological disease (Alzheimer’s Disease) and Diabetic neuropathy - A Concise Review

Abstract

Disorders of the central nervous system are expected to have a profound impact on the global healthcare needs of the human community in this era. Alzheimer disease (AD) is senile decay of neurons. The hallmark of pathophysiology of AD disease has two pivotal features example- extracellular beta amyloid deposition and intracellular tau hyper phosphorylation. New medicine-based psychoactive treatments have met with modest effectiveness due to the multi-factorial nature of these diseases. As a result, there is an increasing need for new products that can address various receptors and enhance behavioural abilities on their own or in tandem with traditional medications. Herbal products focused on conventional expertise have been widely popular in both developed and developing countries in recent years. Ayurveda is a medical science that deals with the treatment of diseases using naturally occurring plant products. Ayurveda claims to have many neuroprotective herbs. In this review the pharmacological effectiveness and therapeutic properties of Bacopa monnieri (BM) against AD and diabetic peripheral neuropathy (DPN) have been discussed. DPN is also an utmost common neuronal disease. DPN affects more than half of diabetic patients who have had diabetes for more than 25 years. It is proved that a bacosides-rich fraction of BM has antinociceptive actions in rats, alleviating allodynia and hyperalgesia in a chronic constriction wound model of neuropathic discomfort. BM may be an important natural cure for the treatment of neuropathic pain syndromes.