Unfavorable Prognosis of Patients With Stage II Non-small Cell Lung Cancer Associated With Macroscopic Nodal Metastases

Prognostic variability among nonsmall cell lung cancer patients with pathologic N1 lymph node involvement

“…6 Recently, some reports have evaluated the prognostic heterogeneity among patients with pN1 lung cancer, and different prognostic subgroups have been suggested. 5,14,15 Results have indicated that patients who have hilar lymph node involvement have a more favorable prognosis compared with patients who have N2 disease, but no statistical significance has been found. 5,16 In other studies, the survival rate among patients with pulmonary lymph node involvement was significantly better than the survival rate among patients with hilar lymph node involvement, 7,14 and recent reports have suggested the possible inclusion of hilar lymph nodes in the N2 lymph node station.…”

Survival and characteristics of lymph node involvement in patients with N1 non-small cell lung cancer

“…However, the 5-year survival rates of patients with N1 disease have reached only 45-60% for T1 disease [1][2][3][4][5][6] and 35-50% for T2 disease [1][2][3][4][5]7]. The TNM staging system should be revised according to the prognosis for patients with relatively homogenous backgrounds.…”

The impact of the type of resection on survival in patients with N1 non-small-cell lung cancers

“…In 1997, lymph nodes were mapped and five stations were defined under N1 lymph nodes [11]. Some researchers argued that N1 was a more reliable prognostic factor, especially in T1 and T2 patients [3,10]. There was no significant survival rate difference between T1 and T2 patients, while our study has the drawback of limited number of T1 patients.…”

“…Several studies have been conducted regarding the factors affecting survival of pN1 lung cancer patients. The prognosis of hilar or interlobar N1 cases is worse than peripheral N1 cases [3,4]. The extent of lymph node involvement in patients with non-small-cell lung cancer (NSCLC) is the most important prognostic factor and influences therapeutic strategies [5].…”