Survival and characteristics of lymph node involvement in patients with N1 non-small cell lung cancer

Prognostic variability among nonsmall cell lung cancer patients with pathologic N1 lymph node involvement

“…6 Recently, some reports have evaluated the prognostic heterogeneity among patients with pN1 lung cancer, and different prognostic subgroups have been suggested. 5,14,15 Results have indicated that patients who have hilar lymph node involvement have a more favorable prognosis compared with patients who have N2 disease, but no statistical significance has been found. 5,16 In other studies, the survival rate among patients with pulmonary lymph node involvement was significantly better than the survival rate among patients with hilar lymph node involvement, 7,14 and recent reports have suggested the possible inclusion of hilar lymph nodes in the N2 lymph node station.…”

“…3 Recently, some authors suggested that, within the subset of patients with pathologic N1 (pN1) disease, the prognosis may differ according to the level of lymph node level. [4][5][6] N1 disease includes patients with early-stage disease and patients with locally advanced disease; survival rates vary between 30% and 50% and seem to be related to lymph node involvement, 4,5 and particularly to the number and type of lymph nodes involved. 6 Currently, some variation in the lymph node map can be found, and one of the most important problems concerning lymph node involvement is the definition of the borderline between N1 and N2 stations 7 : of particular interest are the lymph nodes located around the main bronchus that generally are included in the N1 group.…”

Prognostic factors in resected pathological N1-stage II nonsmall cell lung cancer

“…In recent decades, many authors have suggested that within the subset of patients with pathological N1 disease, the prognosis may differ according to the number, level or type of lymph nodes involved [8][9][10][11][12][13][14]. Stage II NSCLC included a relatively smaller number of patients compared with those with stage I NSCLC.…”

The Number of Lymph Node Metastases as a Prognostic Factor in Patients With N1 Non-small Cell Lung Cancer

“…[7][8][9][10][11][12] However, many of these studies were limited to small cohorts of patients from single institutions and only assessed the impact of single vs multiple LN involvement. [9][10][11] Other studies combined patients with N1 and N2 disease, making it diffi cult to extrapolate their results to N1 disease alone. 8,12 Because of these limitations, the number of N1 nodes has not been adopted as a prognostic factor in clinical practice.…”

“…Some of these studies have shown that multiple, compared with single, LN metastasis is associated with worse prognosis. [9][10][11] Research evaluating the number of positive LNs as a new prognostic factor in N1 NSCLC has shown confl icting results. 5,7,8,12,22 Using similar groupings as ours, Marra et al 7 found an association, in univariate but not in adjusted analysis, between the number of positive nodes and survival in a cohort of patients with resected N1 NSCLC from a single referral center.…”