Unexplained Infertility and Undiagnosed Celiac Disease: Study of a Multiethnic Canadian Population

Gunn, Beth; Murphy, Kellie; Greenblatt, Ellen

doi:10.1016/j.jogc.2017.07.008

Cited by 16 publications

(19 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…European populations were studied in 8 works [9,10,14,17,18,19,23,32], and 8 additional studies consider populations with a predominant Caucasian component [12,13,21,22,25,30,31,33]. The remaining 7 studies include populations from countries with an important representation of different ethnic groups [11,20,24,26,27,28,29].…”

Section: Resultsmentioning

confidence: 99%

“…The definition of CD differs among authors, sometimes including only seroprevalence. Specifically, 10 works were based only on serological results [10,11,18,21,23,25,28,30,31,33] and 13 included a duodenal biopsy after serological screening [9,12,13,14,17,19,20,22,24,26,27,29,32]. It must be also considered that the selected articles were published between 1976 and 2019, and the serological tests used for CD screening vary according to the technological and scientific advances.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

et al. 2019

View full text Add to dashboard Cite

We aimed to estimate the seroprevalence and the prevalence of coeliac disease (CD) in women with reproductive problems. A systematic review of English published articles until June 2019 was performed in PubMed and Scopus using the terms: (infertility and (coeliac disease OR gluten) OR (miscarriage and (coeliac disease OR gluten) OR (abortion and (coeliac disease OR gluten). All articles showing numerical data of anti-transglutaminase type 2 or anti-endomisium antibodies, or intestinal biopsy information were included. The study group comprised women with overall infertility, unexplained infertility, or recurrent spontaneous abortions. Two authors independently performed data extraction using a predefined data sheet. The initial search yielded 310 articles, and 23 were selected for data extraction. After meta-analysis, the pooled seroprevalence was very similar for overall and unexplained infertility, with a pooled proportion of around 1.3%–1.6%. This implies three times higher odds of having CD in infertility when compared to controls. The pooled prevalence could not be accurately calculated due to the small sample sizes. Further studies with increased sample sizes are necessary before giving specific recommendations for CD screening in women with reproductive problems, but current data seem to support a higher risk of CD in these women.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

et al. 2019

View full text Add to dashboard Cite

show abstract

“…(3) examines many of these interesting questions: the authors described the rate of CD in an IVF population and compared this rate with that of the general population, finding, interestingly and in accordance with other recent studies (4,5), no difference in the prevalence of CD. They then compared the IVF success rates in women with and without antibody positivity for CD.…”

mentioning

confidence: 68%

Infertility patients in general and those with celiac disease may be able to breathe a sigh of relief

Acharya

Muasher

2018

Fertility and Sterility

View full text Add to dashboard Cite

“…Untreated and partially treated CeD is associated with an increased risk for poor outcomes such as infertility, osteoporosis, neuropathies, and lymphomas. Adhering to a GFD is associated with a reduction of these outcomes 5 …”

mentioning

confidence: 99%

Novel Nondietary Therapies for Celiac Disease

Alhassan

Yadav

Kelly

et al. 2019

Cellular and Molecular Gastroenterology and Hepatology

View full text Add to dashboard Cite

Celiac Disease (CeD) is defined as a chronic small intestinal immune-mediated enteropathy that is precipitated by exposure to dietary gluten in genetically predisposed individuals. CeD is one of the most common autoimmune disorders affecting around 1% of the population worldwide. Currently, the only acceptable treatment for CeD is strict, lifelong adherence to a gluten-free diet (GFD) which can often present a challenging task. A GFD alone is not sufficient to control symptoms and prevent mucosal damage that can result from unintentional gluten exposure. Moreover, long-term complications can occur in many patients. Consequently, there is an unmet need for non-dietary therapies for the management of CeD. Such therapies could serve as an adjunct to the GFD but eventually may replace it. This review will focus on and discuss non-dietary therapies currently in clinical development for the management of CeD. Methodology We searched clinicaltrials.gov and PubMed to extract articles about celiac disease. We used keywords including, but not limited to, “celiac disease,” “non-dietary,” “therapeutics,” “pathophysiology,” “Endopeptidases,” “tight junction modulators,” “vaccine,” and “Nexvax2”. We focused mainly on articles that conducted pathophysiologic and therapeutic research in human trials.

show abstract

Unexplained Infertility and Undiagnosed Celiac Disease: Study of a Multiethnic Canadian Population

Cited by 16 publications

References 13 publications

Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

Systematic Review and Meta-Analysis of Prevalence of Coeliac Disease in Women with Infertility

Infertility patients in general and those with celiac disease may be able to breathe a sigh of relief

Novel Nondietary Therapies for Celiac Disease

Contact Info

Product

Resources

About