Toxin concentration did not differentiate an individual with CDI from one with asymptomatic carriage. Median stool toxin concentrations in groups with CDI versus carriage differed, but only when groups were defined by detectable stool toxin (versus positive NAAT).
Celiac Disease (CeD) is defined as a chronic small intestinal immune-mediated enteropathy that is precipitated by exposure to dietary gluten in genetically predisposed individuals. CeD is one of the most common autoimmune disorders affecting around 1% of the population worldwide. Currently, the only acceptable treatment for CeD is strict, lifelong adherence to a gluten-free diet (GFD) which can often present a challenging task. A GFD alone is not sufficient to control symptoms and prevent mucosal damage that can result from unintentional gluten exposure. Moreover, long-term complications can occur in many patients. Consequently, there is an unmet need for non-dietary therapies for the management of CeD. Such therapies could serve as an adjunct to the GFD but eventually may replace it. This review will focus on and discuss non-dietary therapies currently in clinical development for the management of CeD.
Methodology
We searched
clinicaltrials.gov
and PubMed to extract articles about celiac disease. We used keywords including, but not limited to, “celiac disease,” “non-dietary,” “therapeutics,” “pathophysiology,” “Endopeptidases,” “tight junction modulators,” “vaccine,” and “Nexvax2”. We focused mainly on articles that conducted pathophysiologic and therapeutic research in human trials.
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