Unexpected Synthesis of 1,3,4‐Oxadiazines using extraordinary effect of SBA‐Pr‐SO₃H as the Nano–catalyst

Abstract

Unexpected synthesis of 1,3,4‐oxadiazines has been accomplished through three‐component reaction of cyclohexyl isocyanide, hydrazide derivatives and cyclic ketones in the presence of a catalytic amount of SBA−Pr‐SO3H as an efficient catalyst. A range of spirooxadiazine derivatives were synthesized in high yields in a concise way. The same three‐component reaction in the presence of other acidic catalysts led to the synthesis of hydrazino amides. The formation of 1,3,4‐oxadiazines is related to the pore size and structure of SBA−Pr‐SO3H which spatial orientation of intermediate onto it leads to the formation of the oxadiazine ring.

Palladium‐anchored multidentate SBA‐15/di‐urea nanoreactor: A highly active catalyst for Suzuki coupling reaction

“…Among the various nanoreactors, mesoporous silicas, particularly SBA‐15, have been widely studied . Large surface areas, highly ordered mesoporous structures with regular channels, high hydrothermal and mechanical stability, uniform pore sizes, thick walls, wide accessibility and inert environment for immobilization of transition metal nanoparticles make these structures excellent carriers for many metal species…”

Applications of SBA-15 supported Pd metal catalysts as nanoreactors in C–C coupling reactions

“…Good recyclability was viewed aer four cycles (Scheme 26). 79 The MW-assisted Suzuki coupling of aryl halides catalyzed with Pd/SBA-15 (22), containing 8.7 mol% Pd, under solvent- free condition has been studied by Chang and co-workers. The reported catalyst was prepared by impregnation of an aqueous solution containing [Pd(NH 3 ) 4 ]Cl 2 on the surface of SBA-15.…”

“…16,17 Among the OMS, the SBA-15 hybrid material, rst synthesized by Stucky's group, 18 with uniform pore size, large specic surface area, high thermal and chemical stability has been widely used as a support in heterogeneous catalysts for synthetic and industrial processes. 2,[19][20][21][22][23][24][25][26][27][28] However, naked SBA-15 has a lack of functionality, hence, its surface was modi-ed by graing or co-condensation to make this material more versatile in terms of its possible applications. 29 An effective method to modication of these silica support catalysts, is creating of anchoring sites for capturing catalytic species.…”

Synthesis, Biological Evaluation and Molecular Docking of Deferasirox and Substituted 1,2,4‐Triazole Derivatives as Novel Potent Urease Inhibitors: Proposing Repositioning Candidate

“…These observations stimulated our interest to study the urease inhibitory activity of the DFX and some of its new derivatives for the first time and investigate the role of OH and various substituted 1,2,4‐triazole groups in the inhibition of urease activity. In this regard and continuation of our research interest in the synthesis of heterocyclic skeletons, we report an efficient procedure for the synthesis of some DFX analogs ( N ‐substituted bis‐hydroxyphenyl‐1,2,4‐triazoles), containing triazole backbone ( Scheme ). The present article, therefore, describes urease inhibitory properties of newly synthesized compounds and investigates their mode of molecular interaction to reveal the probable mechanism class of these compounds, including complexation of nickel ions, blocking the active channel site, or the possibility of covalent interaction with a cysteine residue.…”