Unexpected histopathology results following routine examination of cholecystectomy specimens: How big and how significant?

Hasan, Abdulkarim; Nafie, Khalid; Aldossary, Mohammed Yousef; Ismail, Amal; Monazea, Khaled; Baheeg, Mohamad; Rady, Kamal; Elhawary, Reda; Ibrahim, Adel A.

doi:10.1016/j.amsu.2020.11.019

Cited by 11 publications

(8 citation statements)

References 45 publications

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“…In another study the most common age group affected was between 40-49 years corresponding with our findings 13,14 . Another study in a tertiary care hospital to study histopathological spectrum of gallbladder disease also found chronic cholecystitis to be the most frequent post surgically established histopathologic diagnosis after cholelithiasis 15,16 . A study with large sample size of 1278 samples of gallbladder studied for histopathological proven cholecystitis also found that almost 98% of the samples had chronic cholecystitis on histopathologic reports 17,18 .…”

Section: Resultsmentioning

confidence: 94%

Histopathological Study of Post-Surgical Gallbladder to Establish True Histopathology Proven Chronic Inflammation

Khattak

Kakakhel

et al. 2021

J Gandhara Med Dent Sci

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OBJECTIVES: The aim of this study was to establish true histopathology proven diagnosis of chronic cholecystitis. METHODOLOGY: A cross-sectional study was conducted on 51 post-surgical gallbladders was done to assess their histopathological patterns in a single centered tertiary care hospital. The specimens were studied for chronic cholecystitis, fibrosis, hypertrophy and presence of Rokitansky-Aschoff sinuses. Descriptive analysis was done and associations of the histopathological changes with demographic data of patients were analyzed through Chi-squared test. RESULTS: Fifty-one post cholecystectomy samples of gallbladder were analyzed for histopathological changes with 82.4% showing chronic cholecystitis, 84.3% fibrosis, 64.7% congestion, and more than 60% mild or moderate hypertrophy. Moreover, 49% of the specimens showed Rokitansky-Aschoff sinuses. All these changes suggest chronic inflammation. CONCLUSION: Chronic cholecystitis, fibrosis, and Rokitansky-Aschoff sinuses are the most common histopathological findings in specimens of patients undergone cholecystectomy for cholelithiasis.

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Section: Resultsmentioning

confidence: 94%

Histopathological Study of Post-Surgical Gallbladder to Establish True Histopathology Proven Chronic Inflammation

Khattak

Kakakhel

et al. 2021

J Gandhara Med Dent Sci

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“…No recurrence or malignant transformation was recorded in our study. The unexpected malignant transformation of benign lesions was recorded in several lesions including the AWE, where Song et al found three malignant cases out of 38 AWEs (7.9%) [ 22 , 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Clinico-pathological assessment of surgically removed abdominal wall endometriomas following cesarean section

Hasan

Deyab

Monazea

et al. 2021

Annals of Medicine and Surgery

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Background Over the past few decades, the rate of Cesarean Section (CS) delivery has been rising rapidly and the prevalence of CS-associated complications including Abdominal Wall Endometriomas (AWE) increases with each additional operation. The aim of this study was to evaluate the clinical characteristics, histopathological diagnostic role and surgical management of post-CS AWE through a retrospective case review. Methods We calculated the incidence of AWE and reviewed all the patients underwent surgical removal of Post-CS AWE during the period of 2012–2018 who were diagnosed, treated and followed up for 2–8 years at our tertiary hospital. Results Thirty women with AWE were included. The main symptom in 2/3 of cases was cyclic pain and 4 cases (13.3%) had no symptoms. The mean interval between prior CS and appearance of symptoms was 55.2 months and the mean size of the excised mass was 42 mm. Free surgical margin was less than 9 mm in 9 patients (30%) but no recurrence was recorded among all the studied patients. Pre-operative FNAC diagnosis was performed for only 3 patients (10%) which helped in excluding other potential pathologies. The clinical–pathological agreement value for detection of the nature of the abdominal wall mass was 93.4%. Conclusions Patients with suspected AWE should undergo preoperative cytological biopsy to exclude alternative diagnosis. Wide surgical excision with margin of less than 1 cm could be accepted especially in case of weak abdominal wall. More studies on the post-CS complications; risks, prevention, early detection and proper management should be encouraged.

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“…From that date, incisional nasolacrimal sac biopsy was recommended as a routine in DCR surgery by many surgeons, irrespective of appearance or risk factors [ [13] , [14] , [15] , [16] ]. The occurrence of lacrimal system neoplasms in various age groups from 20 to 90 years was reported, and is invasive to adjacent tissues and has a high recurrence rate; it is commonly misdiagnosed as an obstruction or inflammation then accidently detected during pathology examination which is the most accurate investigation for challenging neoplastic lesions [ [16] , [17] , [18] , [19] , [20] ].…”

Section: Discussionmentioning

confidence: 99%

The predictive value of nasolacrimal sac biopsy in endoscopic dacryocystorhinostomy

Eldsoky

Ismaiel

Hasan

et al. 2021

Annals of Medicine &Amp; Surgery

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Background During dacryocystorhinostomy (DCR), the lacrimal sac wall biopsy is not routinely performed in our hospital, but it is recommended if there is a suspicion of underlying disease other than preoperatively or intraoperatively chronic inflammation. Objective Most of patients with epiphora have different causes of nasolacrimal duct obstruction (NLDO). This study aims to examine how important routine lacrimal sac biopsy is during endoscopic DCR surgery. Patients & methods The study included 50 patients with chronic unilateral epiphora. All patients underwent endoscopic DCR with NLD biopsy. Histopathologic analysis was performed for each specimen. Results The findings of NLD biopsy showed chronic inflammation in 33 cases (66%), chronic dacryocystitis in 9 cases (18%), dacryolith with dacryocystitis in one case, granuloma in 4 cases (8%), rhinoscleroma in 2 cases (4%), and one case had a neoplasm. Histopathologic findings were inflammatory cellular infiltrates in 56%, 30% and 14% in mild, moderate and severe chronic inflammatory state (CIS) score, respectively. Fibrosis in 18%, 20% and 62% in mild, moderate and severe CIS score, respectively. Capillary proliferation in 64%, 32% and 4% in mild, moderate and severe CIS score, respectively. Chronic inflammatory signs in 64%, 32% and 4% in mild, moderate and severe CIS score, respectively. Conclusion Although neoplasm and granuloma are rare cause of lacrimal sac or duct obstruction requiring DCR, they were detected through nasolacrimal assessment and routine intraoperative lacrimal sac biopsy.

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Unexpected histopathology results following routine examination of cholecystectomy specimens: How big and how significant?

Cited by 11 publications

References 45 publications

Histopathological Study of Post-Surgical Gallbladder to Establish True Histopathology Proven Chronic Inflammation

Histopathological Study of Post-Surgical Gallbladder to Establish True Histopathology Proven Chronic Inflammation

Clinico-pathological assessment of surgically removed abdominal wall endometriomas following cesarean section

The predictive value of nasolacrimal sac biopsy in endoscopic dacryocystorhinostomy

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