Unexpected absence of aphasia following left temporal hemorrhage: a case study with functional neuroimaging to characterize the nature of atypical language localization

Schneck, Sarah M.; Entrup, Jillian L; Duff, Melissa C.; Wilson, Stephen M.

doi:10.1080/13554794.2021.1886309

Cited by 4 publications

(1 citation statement)

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“…Because the relation between handedness and the direction of language lateralisation may be at chance level (Mazoyer et al, 2014), premorbid hemispheric dominance for language might be better suggested by the severity of the initial functional impairment. In individuals with strongly right‐lateralised language function, aphasia symptoms tend to be absent after LH stroke damaging perisylvian areas (e.g., Schneck et al, 2021). In cases of more symmetrical organisation, language deficits should be expected, with severity driven, among other things, by a combination of lesion characteristics and degree of lateralisation.…”

Section: Introductionmentioning

confidence: 99%

Time course of right‐hemisphere recruitment during word production following left‐hemisphere damage: A single case of young stroke

Chupina

Sierpowska

Zheng

et al. 2022

Eur J of Neuroscience

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Our understanding of post-stroke language function is largely based on older age groups, who show increasing age-related brain pathology and neural reorganisation. To illustrate language outcomes in the young-adult brain, we present the case of A., a 23 y.o. woman with chronic aphasia from a left-hemisphere stroke affecting the temporal lobe. Diffusion MRI-based tractography indicated that A.'s language-relevant white matter structures were severely damaged. Using magnetoencephalography (MEG), we explored A.'s conceptual preparation and word planning abilities. Context-driven and bare picture-naming tasks revealed naming deficits, manifesting as word-finding difficulties and semantic paraphasias about half of the time. Naming was however facilitated by semantically constraining lead-in sentences. Altogether, this pattern indicates relatively spared conceptual preparation but disrupted lexical and phonological retrieval abilities. MEG revealed that A.'s conceptual and naming-related neural responses were supported by the right hemisphere, compared to the typical left-lateralised brain response of a matched control. Differential recruitment of right-hemisphere structures (330-440 ms postpicture onset) was found concurrently during successful naming (right mid-to-posterior temporal lobe) and word-finding attempts (right inferior frontal gyrus). Disconnection of the temporal lobes via corpus callosum was not critical for recruitment of the right hemisphere in visuallyguided naming, possibly due to neural activity right-lateralising from the outset. We consider that, despite A.'s young age, the presumed strong degree of language lateralisation and extensive structural damage limited her recovery. Although A.'s right hemisphere responded in a timely manner during word planning, its lexical and phonological retrieval abilities remained modest.

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Section: Introductionmentioning

confidence: 99%