Undifferentiated pleomorphic sarcoma of the parotid gland: A rare pediatric case

Abstract

The classification of MFH has been recently debated. Nevertheless, our case is the second report of pediatric MFH involving the parotid gland. Surgical resection is the preferred treatment, but combined chemoradiation may be necessary in the head and neck region.

Management of undifferentiated high‐grade pleomorphic sarcoma of parotid region in elderly women

“…Head and neck localizations are very rare, their prevalence is about 1:1 000 000 . UHPS usually develops in older patients with a peak incidence in the seventh decade, but have also been reported in children . A review of English language literature identified 24 published cases of primary locations of UHPS in the parotid gland (Table ).…”

“…3 UHPS usually develops in older patients with a peak incidence in the seventh decade, but have also been reported in children. 9 A review of English language literature identified 24 published cases of primary locations of UHPS in the parotid gland (Table 1). UHPS is more frequent in adults and is very rare in early childhood 4 as found in the literature where only 2 of the 24 cases described occurred in childhood.…”

“…Until now, a standard therapeutic strategy has not been established, although surgical excision is usually considered the mainstay of treatment. 4,6,9,13 Wide resection with free margins is required, but a complete excision of head and neck localizations can be challenging due to the infiltrative nature and consequent invasion to critical structures. Regional metastases of head and neck sarcomas are almost exclusive of high-grade lesions.…”

Клинический Случай Химиолучевой Терапии Недифференцированной Плеоморфной Саркомы Параменингеальной Локализации У Ребенка

“…Впервые она описана O'Brien и Stout в 1964 году, а в 1980-х годах была признана одной из самых распространенных мягкотканных сарком у взрослых. У детей встречается редко -око-ло 2-6% всех СМТ [2][3][4][5][6].…”

“…Неблагоприятные прогностические факторы этой опухоли -мужской пол, подростковый возраст, первичная локализация в костях, а также глубокая инвазия в ткани [2].…”