Undifferentiated high-grade pleomorphic sarcoma of the larynx treated with partial laringectomy

Cambruzzi, Eduardo; Cruz, Ricardo Pedrini; Gava, Vinícius Grando; Pêgas, Karla Laís

doi:10.1016/j.bjorl.2016.11.005

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…UPS/MFH is an aggressive tumor with high rate of local recurrence and metastasis [16][17][18] therefore, wide surgical excision and obtaining negative margins are recommended. 17 Adjuvant radiotherapy and/or chemotherapy may be considered in large tumors and patients with positive margins. 16 In summary, we describe an additional series of four cases of primary laryngeal sarcoma (►Table 1), which adds on more information about this rare category of laryngeal tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Dedifferentiated liposarcoma is another possibility that should be considered and ruled out by running MDM2 and CDK4 through immunohistochemistry or FISH. UPS/MFH is an aggressive tumor with high rate of local recurrence and metastasis 16 17 18 therefore, wide surgical excision and obtaining negative margins are recommended. 17 Adjuvant radiotherapy and/or chemotherapy may be considered in large tumors and patients with positive margins.…”

Section: Discussionmentioning

confidence: 99%

“…UPS/MFH is an aggressive tumor with high rate of local recurrence and metastasis 16 17 18 therefore, wide surgical excision and obtaining negative margins are recommended. 17 Adjuvant radiotherapy and/or chemotherapy may be considered in large tumors and patients with positive margins. 16 …”

Section: Discussionmentioning

confidence: 99%

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Primary Sarcomas of the Larynx: A Case Series of Four Different Histopathologic Types

Abu-Dayeh,

Murshed,

Ammar

et al. 2023

Avicenna J Med

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Primary laryngeal sarcomas are rare. Their nomenclature and classification are similar to soft tissue counterparts; however, there are notable differences between clinical presentation, behavior, treatment, and follow-up. There is sparse information regarding the clinical features, biologic behavior, and treatment modalities of laryngeal sarcomas. To increase our understanding about these tumors, we describe herein an additional series of four cases of different pathologic types of laryngeal sarcomas, including low-grade chondrosarcoma, leiomyosarcoma, well-differentiated liposarcoma, and undifferentiated pleomorphic sarcoma. Our main aim is to upsurge awareness about the morphologic variations of laryngeal sarcomas, to avoid potential pitfalls during histopathologic examination. It is essential to ensure that correct diagnosis, subclassification, and grading are achieved for proper guidance of treatment and clinical follow-up at multidisciplinary team meetings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Sarcomas of the Larynx: A Case Series of Four Different Histopathologic Types

Abu-Dayeh,

Murshed,

Ammar

et al. 2023

Avicenna J Med

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“…This finding is the mirror of the histological heterogeneity of which the non-SCC cohort is composed. In fact, this group included traditionally aggressive neoplasms, like small cell neuroendocrine carcinoma and pleomorphic sarcoma [ 28 , 29 ], and histotypes with a more indolent biological behavior, such as chondrosarcoma, liposarcoma, and solitary fibrous tumor [ 30 , 31 ]. The SCC cohort, conversely, was mainly composed of moderately differentiated carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Surgical management and oncological outcome of non-squamous cell carcinoma of the larynx: a bicentric study

Iandelli

Missale

Laborai

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose Non-squamous cell carcinoma (non-SCC) accounts for about 5% of laryngeal malignancies. Survival data are limited, and consensus on management principles is lacking. The present study reviews our experience in the surgical treatment of non-metastatic non-SCC of the larynx and compares oncological and functional outcomes in a cohort of patients affected by traditional SCC. Methods We collected data on 592 patients affected by laryngeal neoplasms. Univariate and multivariable survival analyses were performed using Cox proportional-hazards models; survival estimates were reported by hazard ratios (HR) with 95% confidence intervals (CI), and survival curves were established with the Kaplan–Meier method. Results We identified 326 patients affected by untreated SCC, while 21 had non-SCC histotypes. The non-SCC cohort was composed of 5 soft tissue sarcomas, 8 chondrosarcomas, 2 adenoid cystic carcinomas, 2 neuroendocrine carcinomas, 2 solitary fibrous tumors, 1 Kaposi’s sarcoma, and 1 malignant peripheral nerve sheath tumor. Overall survival and disease-specific survival were not significantly different according to histology (p = 0.6 and p = 0.349, respectively). The non-SCC group showed an increased risk of recurrence (HR 5.87; CI95 2.15–16.06; p < 0.001). Nonetheless, no significant difference (p = 0.31) was found at multivariable analysis between the two groups in total laryngectomy-free survival with an organ preservation rate over 5 years of 81% for the non-SCC histologies. Conclusion Non-SCC is a broad spectrum pathology, but generalized laryngeal surgical management principles are still feasible and it is possible to identify patients amenable to conservative surgical treatment without affecting survival.

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“…In addition, these neoplasms' anatomic and pathophysiologic heterogeneity demands variable and multifactorial considerations for effective management. 1 , 2 , 3 …”

Section: Introductionmentioning

confidence: 99%

Long-term follow-up after surgical management of laryngeal malignant pleomorphic sarcoma ‒ a case report

Bandiera

Covelli

Elfarargy

et al. 2023

Brazilian Journal of Otorhinolaryngology

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Undifferentiated high-grade pleomorphic sarcoma of the larynx treated with partial laringectomy

Cited by 8 publications

References 9 publications

Primary Sarcomas of the Larynx: A Case Series of Four Different Histopathologic Types

Primary Sarcomas of the Larynx: A Case Series of Four Different Histopathologic Types

Surgical management and oncological outcome of non-squamous cell carcinoma of the larynx: a bicentric study

Long-term follow-up after surgical management of laryngeal malignant pleomorphic sarcoma ‒ a case report

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