Undifferentiated Connective Tissue Disease in Pregnancy: A Topic Yet to be Explored

Serena, Caterina; Clemenza, Sara; Simeone, Serena; Zullino, Sara; Ottanelli, Serena; Rambaldi, Marianna Pina; Vannuccini, Silvia; Mecacci, Federico

doi:10.3389/fphar.2022.820760

Cited by 5 publications

(5 citation statements)

References 88 publications

(147 reference statements)

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“…Although UCTD is the most common rheumatic disorder diagnosed in pregnant women, 2 data on disease course and maternal-fetal outcomes are limited. One uncontrolled study of 20 pregnant patients with UCTD demonstrated that pregnancy may be a trigger for the development of a defined connective tissue disorder.…”

Section: Discussionmentioning

confidence: 99%

“…1 It can appear to have a mild clinical course and is marked by the absence of severe organ damage or involvement. 1 , 2 Pregnancy represents a possible trigger for the development of a connective tissue disorder; however, the influence of pregnancy on disease course is not well understood. We present the case of a pregnant woman with UCTD with an unusual cutaneous presentation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Palmar and plantar erythema: An initial presentation of undifferentiated connective tissue disease

Sow¹,

Wachuku²,

Barrera³

et al. 2023

JAAD Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Palmar and plantar erythema: An initial presentation of undifferentiated connective tissue disease

Sow¹,

Wachuku²,

Barrera³

et al. 2023

JAAD Case Reports

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“…In our observation group, 30 patients (33.33%) were diagnosed with UCTD, all con rmed through early pregnancy screening. A few patients showed abnormal symptoms, including photosensitivity, morning stiffness, and facial erythema [15] . Obstetric experts recommend that preliminary anti-phospholipid antibody (aPL) screening should be carried out during the transition period (13-14 weeks) when early pregnancy transitions to middle pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes and Maternal-Fetal Conditions in Patients with Autoimmune Diseases: A three-Year Prospective Study

Sun,

Zhu,

et al. 2023

Preprint

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Background Autoimmune disease is a nonnegligible factor of adverse pregnancy events. Our research aims to analyze the pregnancy outcomes and maternal-fetal conditions of patients diagnosed with AID, providing a comprehensive theoretical basis for clinical work. Methods 90 pregnant women with autoimmune diseases who visited our hospital from January 2020 to December 2022 were included as the observation group, 100 pregnant women without autoimmune diseases were enrolled as the control group during the same period. Clinical data were prospectively collected and analyzed. Results 1. Totally 190 patients were included, the average age of the patients was 30.29 ± 3.68 years (ranging from 23 to 43), the average duration was 1.84 ± 2.81 years (varied from 0.5 to 20 years). 2. There were no significant differences in age, gravidity, and BMI distribution among both groups, while there were significant differences in parity, number of mis-carriage, duration of disease, times of hospitalization during pregnancy, clinical symptoms and bishop cervical score at admission, statistically. The parity and cervical score at admission in the observation group were significantly lower than those in the control group. The number of mis-carriage, the times of hospitalization during pregnancy and the positive clinical symptoms were significantly higher than those in the control group. 3. There were 185 live births (97%). The preterm birth rate of the observation group was 18.89% and the full-term birth rate was 77.78%, compared to 2% and 96% of the control group, with significant differences. Weight distribution of fetuses in the study was statistically different, However, here was no difference in sex distribution. 4. The assisted pregnancy of the observation group was higher, while the premature rupture rate of fetal membrane was lower than that of the control group. Incidence of hemorrhage, infection and fetal distress in utero were also statistically different between the two groups. 5. Age, gravidity, parity, duration of disease, delivery mode, pregnancy complications were all related to the outcome of pregnancy. The incidence of miscarriage, asphyxia in neonates and complications during pregnancy in the observation group were significantly higher than those of the control group. Conclusion Pregnancy with autoimmune diseases leads to adverse pregnancy outcomes. Standardized management and multi-disciplinary cooperation are of great significance to improve maternal and fetal prognosis.

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“…Більшість проведених дотепер досліджень у педіатричній практиці щодо НДСТ присвячені вивченню взаємозв'язків між виразністю клініко-біохімічних ознак НДСТ у дітей та підлітків і перебігом диспластикозалежних станів та хвороб [2, 3,10,12,15,16,20,25,26]. Дослідники акушерських аспектів НДСТ акцентують увагу насамперед на рівні захворюваності серед новонароджених від матерів із проявами НДСТ [8,14,22].…”

Section: вступunclassified

The level of serum matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 in newborns from mothers with undifferentiated connective tissue dysplasia

Chumak,

Volokha

2024

UJPP

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Laboratory markers of undifferentiated connective tissue dysplasia (UCTD) are indicators of the matrix metalloproteinases (MMP) system, which are involved in the remodeling of connective tissue components, morphogenesis, inflammation. Purpose - to analyze the correlation between signs of UCTD in postpartum women and the level of serum MMP-1, tissue inhibitor of MMP-1 (TIMP-1) and the MMP-1/TIMP-1 ratio in newborns. Materials and methods. We examined 122 women in labor and their 122 newborn children with a gestational age (GA) of 28-42 weeks, a body weight (BW) of 1270-4070 g. Clinical and anamnestic data and biochemical markers (level of serum MMP-1, TIMP-1, MMP-1/TIMP-1) were investigated in children. Clinical signs of UCTD in women in labor were registered. The main group (n=82) involved women with ≥3 UCTD markers, the control group (n=40) consisted of women with ≤2 UCTD features and their newborns. Accordingly, the main group of newborns - children from mothers with ≥3 markers of UCTD, the control group - babies from mothers with ≤2 signs of UCTD. For statistical analysis, Mann-Whitney (U) test and Cramer’s coefficient (φc) were used. Results. Newborns of the main group had a longer GA (U=1069.5; p=0.002), a lower Apgar score (U=1522.5; p=0.04), a smaller weight-for-age ratio (U=1511.0; p=0.038), higher concentrations of MMP-1 (U=55.0; p=0.000013) and higher values of the MMP-1/TIMP-1 (U=76.0; p=0.000323). The optimal range of MMP-1 in newborns is 2.72-3.91 ng/ml, TIMP-1 - 16.08-17.49 ng/ml, MMP-1/TIMP-1 - 0.16-0.24. MMP-1 concentration ranges ≥4.51 ng/ml and MMP-1/TIMP-1 values ≥0.31 were more typical for full-term infants (p<0.01) than prematurely born, and for children with lower BW (p<0.01). UCTD-associated obstetric complications were related to ranges of MMP-1 ≥4.51 ng/ml (p<0.001-0.05), TIMP-1 ≤16.07 ng/ml (p<0.05), MMP-1/TIMP-1 ≥0.31 (p<0.001-0.05) in children. Conclusions. UCTD in parturient mothers is an unfavorable factor in the formation of small weight-for-age ratio (p=0.038), a low postnatal adaptation (p=0.04), imbalance of serum MMP-1 (p=0.000013) and MMP-1/TIMP-1 (p=0.000323) in children. The optimal level of serum MMP-1 for newborns is 2.72-3.91 ng/ml, TIMP-1 - 16.08-17.49 ng/ml, MMP-1/TIMP-1 - 0.16-0.24. The values of MMP-1 ≥4.51 ng/ml and MMP-1/TIMP-1 ≥0.31 are markers of delayed physical development of the fetus (p<0.01). UCTD-associated obstetric complications are prognostically unfavorable for imbalance of MMP-1, TIMP-1, MMP-1/TIMP-1 in newborns. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of an institution. The informed consent to participate in the study was obtained from each mother. No conflict of interests was declared by the authors.

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Undifferentiated Connective Tissue Disease in Pregnancy: A Topic Yet to be Explored

Cited by 5 publications

References 88 publications

Palmar and plantar erythema: An initial presentation of undifferentiated connective tissue disease

Palmar and plantar erythema: An initial presentation of undifferentiated connective tissue disease

Pregnancy Outcomes and Maternal-Fetal Conditions in Patients with Autoimmune Diseases: A three-Year Prospective Study

The level of serum matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1 in newborns from mothers with undifferentiated connective tissue dysplasia

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