Undetectable levels of serum FSH immunoactivity and bioactivity in girls with sexual precocity due to ovarian cysts

Abstract

Low LCK, Wang C, Leung A, Leong LY. Undetectable levels of serum FSH immunoactivity and bioactivity in girls with sexual precocity due to ovarian cysts. Acta Paediatr 1994;83:623-6. Stockholm.Clinical presentation and endocrine investigations in five girls with precocious sexual development due to ovarian cysts are presented. These girls had pubertal oestradiol and suppressed gonadotrophin responsiveness to LHRH stimulation. FSH bioactivity as measured by the rat aromatase assay was undetectable in basal and LHRH-stimulated serum samples but our results cannot exclude the possibility of the presence of a species-specific follicle stimulating factor in these patients. IM injection of depot medroxyprogesterone acetate controlled pubertal development in two children. 0 Ovarian cysts, precocious puberty, undetectable FSH bioactivity

Endocrine manifestations of ovarian lesions in children: an 11 year review

“…Multiple small follicular cysts are common findings in the ovaries of prepubertal girls 13 . At times, large ovarian cysts can occur producing oestrogen which causes sexual precocity in these children 13,14 . There are several studies reporting precocious sexual development associated with unilateral 14,15 and bilateral 16 follicular cysts.…”

“…At times, large ovarian cysts can occur producing oestrogen which causes sexual precocity in these children 13,14 . There are several studies reporting precocious sexual development associated with unilateral 14,15 and bilateral 16 follicular cysts. Whilst the plasma and/or urinary oestradiol levels were raised in most of the patients 14,15 , all of them had suppressed gonadotrophin levels 14,15,16 .…”