Understanding the transmission pathways of Lassa fever: A mathematical modeling approach

Monoclonal antibody therapy protects nonhuman primates against mucosal exposure to Lassa virus

“…Mastomys rodents infected with LASV are eaten as bush meat in some locations directly resulting in human cases of LF. 10 Contamination of food and food surfaces with rodent excreta can also result in transmission of LASV to humans. 10 , 11 Another route of transmission is by exposure to airborne particles, which can occur through the inhalation of particles contaminated with the urine and droppings of LASV-infected rodents particularly during activities like sweeping or dusting.…”

“… 10 Contamination of food and food surfaces with rodent excreta can also result in transmission of LASV to humans. 10 , 11 Another route of transmission is by exposure to airborne particles, which can occur through the inhalation of particles contaminated with the urine and droppings of LASV-infected rodents particularly during activities like sweeping or dusting. 12 Previous studies have shown that LASV is stable as an aerosol, and the biological half-life ranges from approximately 10 to 55 min depending on the temperature and humidity, 13 while the decay rate of LASV in a small-particle aerosol was determined to be 2.69% per minute.…”

A validate and standardized pseudotyped microneutralization assay as a safe and powerful tool to measure LASSA neutralising antibodies for vaccine development and comparison

“…2 First described in 1969 in Lassa, Nigeria, 3 LF is currently endemic in West and Central Africa, including Nigeria, Sierra Leone, Guinea, Liberia, Benin, Ghana and Mali and neighbouring countries. 4,5 Worldwide, sporadic cases of LASV infection have been reported in Europe, Japan, and the USA, imported by travellers from West Africa. [6][7][8] LASV is an enveloped-RNA virus with a genome consisting of two ambisense, single-stranded RNA segments, large (L) and small (S).…”

“…13 Less commonly, horizontal human-to-human transmission of LASV can occur, posing a higher risk to health care, which increases with disease progression and increasing viral load. 14,15 LASV infection is heterogeneous: 80% of infected individuals are asymptomatic or present with mild, non-specific symptoms; 20% of infected individuals present with severe symptoms, including haemorrhaging, respiratory distress, repeated vomiting, facial swelling, chest, back and abdominal pain, and shock. 8 Central nervous system manifestations and renal failure are strongly associated with a poor outcome 16 ; in the worst cases, death can occur within 14 days of symptom onset due to multiple organ failure.…”

Lassa Fever: Patients Profile and Treatment Outcomes at Benue State University Teaching Hospital Makurdi, North-Central Nigeria

“…The Lassa fever virus is spread by contact with excretions or secretions (including feces and urine) of infected rats accessing food items and water within human households and other locations with human activities such as when the rats are killed and processed for consumption. The information available demonstrates that human-to-human transmission occurs by contact with the bodily fluids, secretions, excretions, blood of the infected individual, and sexual transmission [6]. There is no epidemiological data indicating airborne transfer between people [7] [8].…”