Understanding the transcriptional regulation of cervix cancer using microarray gene expression data and promoter sequence analysis of a curated gene set

Srivastava, Prashant K.; Mangal, Manu; Agarwal, Subhash Mohan

doi:10.1016/j.gene.2013.11.028

Cited by 20 publications

(14 citation statements)

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“…E2Fs are regulators of genes required for cell cycle progression, DNA replication, apoptosis and cell differentiation [ 30 ]. Srivastava et al (2014) identified E2F as a potential biomarker that is assumed to regulate the transcription of a group of genes associated with cervical cancer and might thereby act as a potential molecular target for the treatment of this malignancy [ 31 ]. The inactivation of E2F repressor-Rb by HPV E7 leads to a deregulation of E2F activity and consequently to increased levels of proteins whereby transcriptional regulation is controlled [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of RIP140 and LCoR as independent markers for poor prognosis in cervical cancer

et al. 2017

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IntroductionRIP140 (Receptor Interacting Protein) is involved in the regulation of oncogenic signaling pathways and in the development of breast and colon cancers. The aim of the study was to analyze the expression of RIP140 and its partner LCoR in cervical cancers, to decipher their relationship with histone protein modifications and to identify a potential link with patient survival.MethodsImmunohistochemical analyses were carried out to quantify RIP140 and LCoR expression in formalin-fixed paraffin-embedded tissue sections cervical cancer samples. Correlations of RIP140 and LCoR expression with histopathological variables were determined by correlation analyses. Survival rates of patients expressing low or high levels of RIP140 and LCoR were compared by Kaplan-Meier curves.ResultsRIP140 overexpression was associated with a significantly shorter overall survival of cervical cancer patients. This effect was significant in the squamous cell carcinoma subtype but not in adenocarcinomas. RIP140 is no longer a significant negative prognosticator for cervical cancer when LCoR expression is low.DiscussionRIP140 is an independent predictor of poor survival of patients with cervical cancer. Patients with tumors expressing low levels of both RIP140 and LCoR showed a better survival compared to patients expressing high levels of RIP140. Modulation of RIP140 and LCoR may represent a novel targeting strategy for cervical cancer prevention and therapy.

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Section: Discussionmentioning

confidence: 99%

Investigation of RIP140 and LCoR as independent markers for poor prognosis in cervical cancer

et al. 2017

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“…Gene expression is known to be regulated by contact between transcription factors (TFs) and upstream regulatory elements of target genes [92]. Furthermore, miRNAs expression can be activated or repressed by TFs, which therefore can serve as miRNA regulators [93].…”

Section: Causes Of Disturbed Mirna Expression In Cervical Cancermentioning

confidence: 99%

A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer

Sharma

Dua

Agarwal

2014

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MicroRNAs(miRNAs) have become the center of interest in oncology. In recent years, various studies have demonstrated that miRNAs regulate gene expression by influencing important regulatory genes and thus are responsible for causing cervical cancer. Cervical cancer being the third most diagnosed cancer among the females worldwide, is the fourth leading cause of cancer related mortality. Prophylactic human papillomavirus (HPV) vaccines and new HPV screening tests, combined with traditional Pap test screening have greatly reduced cervical cancer. Yet, thousands of women continue to be diagnosed with and die of this preventable disease annually. This has necessitated the scientists to ponder over ways of evolving new methods and chalk out novel treatment protocols/strategies. As miRNA deregulation plays a key role in malignant transformation of cervical cancer along with its targets that can be exploited for both prognostic and therapeutic strategies, we have collected and reviewed the role of miRNA in cervical cancer. A systematic search was performed using PubMed for articles that report aberrant expression of miRNA in cervical cancer. The present review provides comprehensive information for 246 differentially expressed miRNAs gathered from 51 published articles that have been implicated in cervical cancer progression. Of these, more than 40 miRNAs have been reported in the literature in several instances signifying their role in the regulation of cancer. We also identified 40 experimentally validated targets, studied the cause of miRNAs dysregulation along with its mechanism and role in different stages of cervical cancer. We also identified and analysed miRNA clusters and their expression pattern in cervical cancer. This review is expected to further enhance our understanding in this field and serve as a valuable reference resource.

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“…Due to the limitation of experiment, the development of microarray and sequencing technology provided an excellent tool and platform for cancer research 11 - 13 . By associating clinical data with molecular mechanism, new biomarkers for diagnosis, treatment and prognosis might be recovered.…”

Section: Introductionmentioning

confidence: 99%

Ten hub genes associated with progression and prognosis of pancreatic carcinoma identified by co-expression analysis

et al. 2018

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Since the five-year survival rate is less than 5%, pancreatic ductal adenocarcinoma (PDAC) remains the 4th cause of cancer-related death. Although PDAC has been repeatedly researched in recent years, it is still predicted to be the second leading cause of cancer death by year 2030. In our study, the differentially expressed genes in dataset GSE62452 were used to construct a co-expression network by WGCNA. The yellow module related to grade of PDAC was screened. Combined with co-expression network and PPI network, 36 candidates were screened. After survival and regression analysis by using GSE62452 and TCGA dataset, we identified 10 real hub genes (CCNA2, CCNB1, CENPF, DLGAP5, KIF14, KIF23, NEK2, RACGAP1, TPX2 and UBE2C) tightly related to progression of PDAC. According to Oncomine database and The Human Protein Atlas (HPA), we found that all real hub genes were overexpressed in pancreatic carcinoma compared with normal tissues on transcriptional and translational level. ROC curve was plotted and AUC was calculated to distinguish recurrent and non-recurrent PDAC and every AUC of the real hub gene was greater than 0.5. Finally, functional enrichment analysis and gene set enrichment (GSEA) was performed and both of them showed the cell cycle played a vital role in PDAC.

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Understanding the transcriptional regulation of cervix cancer using microarray gene expression data and promoter sequence analysis of a curated gene set

Cited by 20 publications

References 51 publications

Investigation of RIP140 and LCoR as independent markers for poor prognosis in cervical cancer

Investigation of RIP140 and LCoR as independent markers for poor prognosis in cervical cancer

A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer

Ten hub genes associated with progression and prognosis of pancreatic carcinoma identified by co-expression analysis

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