Understanding the role of cytokines in Glioblastoma Multiforme pathogenesis

Zhu, Vivian F.; Yang, Jingxuan; LeBrun, Drake G.; Li, Min

doi:10.1016/j.canlet.2011.11.001

Cited by 105 publications

(104 citation statements)

References 99 publications

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“…Previously, several studies have suggested that PAX6 acts as a tumor suppressor in malignant glioma (4,5). As one of the most common types of primary brain cancer, the prognosis of malignant glioma is very poor, mainly due to its resistance to radiotherapy, chemotherapy or adjuvant therapies (6)(7)(8). The median survival rate of glioma has not improved over the last decade, despite the development of therapeutic strategies for various types of human cancer (9).…”

Section: Introductionmentioning

confidence: 99%

PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells

Cheng

Cao²,

Chen

et al. 2014

Molecular Medicine Reports

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Abstract. Paired box 6 (PAX6), a highly conserved transcription factor, is important in glioma. However, the molecular mechanisms involved remain unclear. The present study demonstrated that the expression of PAX6 was significantly reduced with the malignancy of glioma and also identified PAX6 as a novel target of microRNA (miR)-335, which was significantly upregulated in glioma. The inhibition of miR-335 increased the protein expression of PAX6, whereas the upregulation of miR-335 suppressed its expression in human glioma U251 and U87 cells. Furthermore, upregulation of miR-335 promoted U251 cell proliferation, colony formation and invasion, which was reversed by the overexpression of PAX6. Furthermore, the present study demonstrated that the effect of miR-335 on U251 cell invasion was via the modulation of matrix metalloproteinase (MMP)-2 and MMP-9 expression by targeting PAX6. In conclusion, the present study demonstrated that PAX6, as a novel target of miR-335, has an anti-oncogenic function in glioma, and thus PAX6 may serve as a therapeutic target for glioma.

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Section: Introductionmentioning

confidence: 99%

PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells

Cheng

Cao²,

Chen

et al. 2014

Molecular Medicine Reports

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“…5,[9][10][11][21][22][23][24][25] To our knowledge, our study if the first using a xMAP system to simultaneously assess expression levels of several circulating factors in cancer patients at the baseline and in the post-operatory while carefully controlling for cigarette smoking and other potential confounders.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic surgery for colorectal cancer is not associated with an increase in the circulating levels of several inflammation-related factors

Crucitti

Corbi

Tomaiuolo

et al. 2015

Cancer Biology & Therapy

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“…31,34,36 Emerging evidence suggests that the presence of inflammatory cytokines may enhance glioblastoma growth as well as suppress apoptotic and senescent processes within glioblastomas. 6,36 The inflammatory markers upregulated in astrocytomas in the current analysis may reflect the increased number of microglia in astrocytic gliomas relative to oligodendrogliomas 7,26 or the inherent expression of cytokines by astrocytic gliomas. 12,19,35,36 Aberrant miRNA expression is a universal theme during carcinogenesis.…”

Section: Diagnostic Uncertainty In Discriminating Betweenmentioning

confidence: 99%

The Cancer Genome Atlas expression profiles of low-grade gliomas

Gonda

Cheung

Muller

et al. 2014

FOC

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Differentiating between low-grade gliomas (LGGs) of astrocytic and oligodendroglial origin remains a major challenge in neurooncology. Here the authors analyzed The Cancer Genome Atlas (TCGA) profiles of LGGs with the goal of identifying distinct molecular characteristics that would afford accurate and reliable discrimination of astrocytic and oligodendroglial tumors. They found that 1) oligodendrogliomas are more likely to exhibit the glioma-CpG island methylator phenotype (G-CIMP), relative to low-grade astrocytomas; 2) relative to oligodendrogliomas, low-grade astrocytomas exhibit a higher expression of genes related to mitosis, replication, and inflammation; and 3) low-grade astrocytic tumors harbor microRNA profiles similar to those previously described for glioblastoma tumors. Orthogonal intersection of these molecular characteristics with existing molecular markers, such as IDH1 mutation, TP53 mutation, and 1p19q status, should facilitate accurate and reliable pathological diagnosis of LGGs.

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Understanding the role of cytokines in Glioblastoma Multiforme pathogenesis

Cited by 105 publications

References 99 publications

PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells

PAX6, a novel target of miR-335, inhibits cell proliferation and invasion in glioma cells

Laparoscopic surgery for colorectal cancer is not associated with an increase in the circulating levels of several inflammation-related factors

The Cancer Genome Atlas expression profiles of low-grade gliomas

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