Laparoscopic surgery for colorectal cancer is not associated with an increase in the circulating levels of several inflammation-related factors

Crucitti, Antonio; Corbi, Maddalena; Tomaiuolo, Pasquina M. C.; Fanali, Caterina; Mazzari, Andrea; Lucchetti, Donatella; Migaldi, Mario; Sgambato, Alessandro

doi:10.1080/15384047.2015.1026476

Cited by 29 publications

(37 citation statements)

References 32 publications

(59 reference statements)

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“…Several studies have demonstrated a significant association between cytokine levels and increased CRC risk (Fan et al, 2011) or severity (Stanilov et al, 2014). However, others have failed to establish a link between TNF-α and susceptibility to this disease (Landi et al, 2006;Crucitti et al, 2015). The -308 (rs1800629) and -238 (rs361525) polymorphisms in the promoter region of the TNF-α gene have been reported to correlate with increased TNF-α production (Cereda et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

et al. 2016

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ABSTRACT. The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CRC patients and controls (P = 0.001), but no relationship between the -308G>A and -238G>A polymorphisms and increased CRC risk was established (P > 0.05). However, an association between the -308G>A variant and disease became evident when the distribution of AA-GA genotypes was examined in patients with hematologic toxicity (neutropenia) and those without (odds ratio = 3.356, 95% confidence interval = 1.295-8.698, P = 0.013). The GG haplotype was more common in controls than CRC patients, with a frequency of 0.85 among the former, but this difference was not significant (P > 0.05). In conclusion, TNF-α serum levels and AA-AG genotypes of the TNF-α -308G>A polymorphism may significantly contribute to CRC susceptibility in the population examined in this investigation.

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Section: Introductionmentioning

confidence: 99%

Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

et al. 2016

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Section: Discussionmentioning

confidence: 99%

“…Preoperative tumor burden and inflammation might explain these observations in part, because malignancies have been shown to alter the levels of cytokines compared to benign diseases needing surgical interventions (16). Namely, the preoperative levels of IL-1β, IL-7, IL-8, G-CSF, IFN-γ, and TNF-α were significantly increased in patients with colon cancer, while these cytokines remained low in patients with other diseases (16). The altered cytokine levels before surgery were likely to have occurred in the present study due to different states of cancer advancement and/or different types of tumors, and such preoperative differences might have consequently hampered detection of the effects of TJ-100.…”

Section: Discussionmentioning

confidence: 99%

“…However, we noted that the cytokine levels differed substantially among individuals. The range of factors potentially influencing cytokine levels, including gene polymorphisms (14,15), malignancy itself (16), and different degree of pre/postoperative inflammation, might have masked the effect of TJ-100. We also considered that cytokine levels of drainage fluid are not suitable for evaluating the effects of TJ-100, because they would be more influenced by the local environment near the tip of the tube than by the whole environment or systemic response.…”

Section: Transition Of Serum Cytokines Following Pancreaticoduodenectmentioning

confidence: 99%

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Transition of serum cytokines following pancreaticoduodenectomy: A subsidiary study of JAPAN‑PD

et al. 2018

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Our previous study aimed to examine the effect of TJ-100, a widely used herbal medicine, on intestinal function following pancreaticoduodenectomy (PD) in a multicenter, randomized, double-blinded, placebo-controlled manner (JAPAN-PD study). This concomitant study investigated the effect of TJ-100 on serum cytokine levels in patients who underwent PD. Due to the fact that several clinical variables can affect the absolute values of baseline serum cytokine levels, the ratios of the cytokine levels on postoperative day (POD)3 to those on POD1 were also used for analysis. The present study enrolled 180/224 randomized patients, of whom 91 received TJ-100 and 89 received placebo. As the main findings of the analysis, Wilcoxon signed-rank test revealed no significant difference in the levels of serum cytokines between the groups; however, patients in the TJ-100 group without severe inflammatory complications exhibited significantly higher ratios of interleukin (IL)-4 (n=123), IL-9 (n=72), IL-10 (n=97), PDGF-BB (n=143) and tumor necrosis factor-α (n=135), compared with patients in the Placebo Group (P<0.05). According to the results of the present study, TJ-100 has an effect on the change in serum cytokine levels from POD1 to POD3 following PD. However, the role of different transition pattern of cytokines in postoperative recovery following PD has to be investigated by further mechanical studies focusing on these extracted cytokines (ClinicalTrials.gov; no. NCT01607307; May 30, 2012).

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“…Chatterjee et al (37) demonstrated that high levels of IFN-γ produced by T cells in contact with MSCs resulted in the activation of the immunosuppressive effect of MSCs. Crucitti et al (38) assessed the therapeutic effect of MSCs by measuring inflammatory cytokines such as TNF-α, IFN-γ, IL-6 and IL-1β, and chemokines, such as macrophage inhibitory protein II, which were significantly decreased in treated mice. Hengartner et al (39) assessed the MSC therapeutic effect by measuring the RNA expression of inflammatory mediators such as TNF-α, IL-1β, cyclo-oxygenase 2, basic fibroblast growth factor, hepatocyte growth factor and vascular endothelial growth factor, all of which significantly decreased in MSC-treated mice.…”

Section: Discussionmentioning

confidence: 99%

Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis

Hu¹,

Zhao²,

Zhang³

et al. 2016

Experimental and Therapeutic Medicine

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One of the primary targets of the clinical treatment of ulcerative colitis (UC) is to repair the damaged colonic mucosa. Mesenchymal stem cells (MSCs) have therapeutic potential in regenerative medicine due to their differentiation capacity and their secretion of numerous bioactive molecules. The present study describes a clinical trial (trial registration no. NCT01221428) investigating the safety and therapeutic effect of MSCs derived from human umbilical cord on moderate to severe UC. Thirty-four patients with UC were included in group I and treated with MSC infusion in addition to the base treatment, and thirty-six patients were in group II and treated with normal saline in addition to the base treatment. One month after therapy, 30/36 patients in group I showed good response, and diffuse and deep ulcer formation and severe inflammatory mucosa were improved markedly. During the follow up, the median Mayo score and histology score in group I were decreased while IBDQ scores were significantly improved compared with before treatment and group II (P<0.05). Compared with group II, there were no evident adverse reactions after MSC infusion in any of the patients in group I, and no chronic side effects or lingering effects appeared during the follow-up period. In conclusion, MSC infusion might be a useful and safe therapy for treating UC.

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Laparoscopic surgery for colorectal cancer is not associated with an increase in the circulating levels of several inflammation-related factors

Abstract: (2015) Laparoscopic surgery for colorectal cancer is not associated with an increase in the circulating levels of several inflammation-related factors, Cancer Biology & Therapy, 16:5,[671][672][673][674][675][676][677]

Cited by 29 publications

References 32 publications

Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients

Transition of serum cytokines following pancreaticoduodenectomy: A subsidiary study of JAPAN‑PD

Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis

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