Understanding the role of active components from plant sources in obesity management

Mir, Shabir Ahmad; Shah, Manzoor Ahmad; Ganai, Shaiq Ahmad; Ahmad, Tariq; Gani, Murtaza

doi:10.1016/j.jssas.2017.04.003

Cited by 35 publications

(21 citation statements)

References 78 publications

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“…Few clinical trials with young adults treated orally with pulp nectar or encapsulated freeze-dried pulp by 15 days found amelioration in biochemical parameters of obesity, due to the reduction of triacylglycerols and total cholesterol levels [55,56,69]. These hypolipidemic and anti-obesity actions can be attributed to the polyphenolic compounds of camu-camu, because these phytochemicals may inhibit adipocyte differentiation, provoke apoptosis in adipocyte, suppress gut lipid transport, intake of glucose by myocytes, suppress lipid anabolism, and promote catabolism in cells of adipose, liver, and other tissues [70,71]. Also, according to Yang et al [71], the two principal mechanisms of body weight loss and metabolic syndrome mitigation by polyphenols of Camellia sinensis are (1) decreasing intestinal transport of lipids and proteins and (2) activating AMP-activated protein kinase in cells of the liver, skeletal muscle, and adipose tissues.…”

Section: Hypolipidemic and Anti-obesity Activitiesmentioning

confidence: 99%

Bioactive Compounds of Camu-Camu (Myrciaria dubia (Kunth) McVaugh)

Castro

Maddox

Cobos³

et al. 2019

Reference Series in Phytochemistry

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Camu-camu is a shrub, native to the Amazon that thrives in areas where flooding is frequent. Genetically, the plant is characterized by a diploid genome and moderate genetic diversity. Several parts of the plant are used in traditional folk medicine to treat a variety of acute and chronic diseases. For over 50 years, the exceptionally high vitamin C content of camu-camu has attracted worldwide attention that continues today because of the recent discovery of several healthpromoting phytochemicals with corroborated biological activities (e.g., antioxidant, anti-obesity, antidiabetic). All of these beneficial attributes are well supported by in vitro and in vivo studies as well as human clinical trials. The metabolic precursors of these phytochemicals are synthesized in key metabolic pathways (i.e., the shikimate pathway, the mevalonate pathway). Of these metabolic pathways, we show details for the biosynthesis of betulinic acid, transresveratrol, and syringic acid. In conclusion, camu-camu is an exceptional plant for its ability to produce and accumulate significant amounts of a variety of health-promoting phytochemicals. Although several metabolic pathways responsible for the biosynthesis of these phytochemicals have been reconstructed based on fruit and seedling transcriptomes, detailed knowledge of the vast majority of metabolic pathways and their molecular regulatory mechanisms is lacking. Consequently, we must increase our knowledge of the metabolic processes using multi-omic approaches so that we can acquire the skills necessary to develop genetically improved varieties of camu-camu and implement biotechnological applications for the production of these bioactive phytochemicals.

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Section: Hypolipidemic and Anti-obesity Activitiesmentioning

confidence: 99%

Bioactive Compounds of Camu-Camu (Myrciaria dubia (Kunth) McVaugh)

Castro

Maddox

Cobos³

et al. 2019

Reference Series in Phytochemistry

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“…The lower the quantities of tannin in sorghum, the higher the nutritional value of the sorghum. Tannins are known to bind to and lower the digestibility of different nutritional values and negatively affecting the productivity of animals 21,25 .…”

Section: Total Tannin Contentmentioning

confidence: 99%

TANNIN AND ANTIOXIDANT STATUS OF FERMENTED AND DRIED Sorghum bicolor

Olawole¹,

Olalere²,

Adeyemi³

et al. 2019

RJC

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The effects of some processing and extraction techniques on the tannin content and antioxidant activities of Sorghum bicolor (Linn) were evaluated. The ethanolic, methanolic and water extracts from the sorghum seeds were assessed after being fermented, or oven-dried for 0 (OVD-0), 30 (OVD-30) and 60 (OVD-60) mins, along with those of the chaff collected after fermentation, and the unprocessed sorghum (control). Tannin, total flavonoids, total phenol, polyphenol contents and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging analysis were determined. All the processing techniques combined with the extraction methods significantly reduced (p<0.05) the tannins. OVD-30 combined with methanol extraction, and all the oven-drying techniques combined with aqueous extraction significantly increased (p<0.05) the flavonoids contents. Flavonoids levels in other methanol extracts and the ethanol extracts of sorghum seeds subjected to oven-drying methods were reduced significantly (p<0.05). The amount of phenolic extracted with both ethanol and methanol significantly increased (p>0.05) during the period of oven-drying. The phenolic contents in the seeds were reduced significantly (p<0.05) when extracted with an aqueous solution. The amount of polyphenols was increased significantly (p<0.05) by ethanol extraction when treated with air-drying (OVD-0). The DPPH scavenging activity was increased significantly (p<0.05) by the processing methods when subjected to either aqueous or methanolic extraction. Fermentation and oven-drying are a highly effective method of reducing the anti-nutritional factors of sorghum. Therefore, the therapeutic values of the processed sorghum seeds may be improved during consumption.

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“…Las saponinas o triterpenoides, se clasifican como polifenoles, y son abundantes en la soya. Varios estu- dios han demostrado que las saponinas inhiben la actividad de la lipasa pancreática en modelo in vitro y en ratones, lo que significa que las saponinas inhibieron la absorción intestinal de grasa dietética [6] .…”

Section: Tipos De Sustancias Bioactivas Terpenosunclassified

“…Los fenoles son sustancias formadas por un grupo hidroxilo en un anillo aromático [4] . Los compuestos fenólicos están ampliamente presentes en el reino animal y constituyen uno de los más importantes grupos de metabolitos secundarios en plantas [6,21] , y son empleados como defensa natural en contra de plagas y enfermedades que incluyen nemátodos parásitos [4] . Los polifenoles están clasificados en ácidos fenólicos, flavonoides, incluidos cumarina, furano cumarinas, flavones, isoflavonoides, taninas, isoflavones, flavanones, antocianidinas, flavanoles, glucosinolatos, ligninas y materiales con sulfuro [4] .…”

Section: Fenolesunclassified

“…Estas sustancias activas pueden modelar las rutas moleculares y las expresiones gene/proteína que permitan utilizarlos de una menera benéfica para tratar algún padecimiento. Por ejemplo, se ha encontrado que los antioxidantes, tales como los polifenoles, los flavonoides y la quercetina son agentes protectores para disminuir la inflamación oxidativa asociada con la ganancia de peso corporal y, por lo tanto, son utilizados para tratar diferentes enfermedades asociadas con la obesidad [6] .…”

Section: Introductionunclassified

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Uso de Biomateriales Funcionalizados con Moléculas Bioactivas en la Ingeniería Biomédica

Reyes-Blas

Olivas–Armendáriz

Martel-Estrada

et al.

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El artículo expone la importancia del uso de moléculas bioactivas para la funcionalización de biomateriales. Por esta razón, se realizó una revisión de investigaciones actuales y relevantes en diversos buscadores de datos, incluyendo los diferentes tipos de materiales y moléculas bioactivas utilizadas para elaborar biomateriales funcionalizados, con énfasis en los procesos y sus propiedades. Se encontró que el proceso de funcionalización o modificación de la su- perficie expande el camino para adaptar al biomaterial de acuerdo al entorno fisiológico de las células vivas. De esta manera, el proceso mejora la estructura y las funciones de los tejidos y órganos diseñados. Existen una variedad de métodos y moléculas bioactivas disponibles para la funcionalización de los biomateriales, las cuales dependen de la manera en las que las células o tejidos se regeneran. Entre los diferentes materiales para la fabricación de bioma- teriales, las biomoléculas como las proteínas, lípidos, carbohidratos, entre otros, son una de las opciones más utili- zadas debido a la similitud de estas con los sistemas biológicos del cuerpo humano. Finalmente, el artículo también integra algunas de las más prometedoras aplicaciones de moléculas bioactivas incorporadas a los biomateriales.

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Understanding the role of active components from plant sources in obesity management

Cited by 35 publications

References 78 publications

Bioactive Compounds of Camu-Camu (Myrciaria dubia (Kunth) McVaugh)

Bioactive Compounds of Camu-Camu (Myrciaria dubia (Kunth) McVaugh)

TANNIN AND ANTIOXIDANT STATUS OF FERMENTED AND DRIED Sorghum bicolor

Uso de Biomateriales Funcionalizados con Moléculas Bioactivas en la Ingeniería Biomédica

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